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Q8K9W6

- ACKA_BUCAP

UniProt

Q8K9W6 - ACKA_BUCAP

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Protein
Acetate kinase
Gene
ackA, BUsg_169
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction By similarity.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+. Can also accept Mn2+ By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi13 – 131Magnesium By similarity
Binding sitei20 – 201ATP By similarity
Binding sitei94 – 941Substrate By similarity
Active sitei153 – 1531Proton donor/acceptor By similarity
Sitei185 – 1851Transition state stabilizer By similarity
Sitei246 – 2461Transition state stabilizer By similarity
Metal bindingi390 – 3901Magnesium By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi213 – 2175ATP By similarity
Nucleotide bindingi288 – 2903ATP By similarity
Nucleotide bindingi336 – 3405ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acetate kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
  2. organic acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-178-MONOMER.
UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinase (EC:2.7.2.1)
Alternative name(s):
Acetokinase
Gene namesi
Name:ackA
Ordered Locus Names:BUsg_169
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Acetate kinaseUniRule annotation
PRO_0000107539Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi198804.BUsg169.

Structurei

3D structure databases

ProteinModelPortaliQ8K9W6.

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.

Phylogenomic databases

eggNOGiCOG0282.
KOiK00925.
OMAiKYVTQRA.
OrthoDBiEOG69975F.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase.
InterProiIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiPS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K9W6-1 [UniParc]FASTAAdd to Basket

« Hide

MVKILNNLIF VLNCGSSSVK FAILNPDNKK KYLSGLVECL FLSKTYMKWK    50
DLTTEHKKCI GSNLSHKDAL NFIFNKFFLE KKDIYKNIVG IGHRVVHGGN 100
KIKSSTLIDD NIIQLIQKAI SFAPLHNPAN LIGIKTAIEK FPIFAKKNVA 150
VFDTSFYQNM PETSFLYAIP YFFYKEHHIR RYGAHGTSHH YVASEVALIL 200
NKNFNSLNVI TCHLGNGASV SAVCNGICVD TSMGLTPLEG LVMGTRSGDI 250
DPSIIFFMYQ KLGMSIDEIH TILTKESGLL GLSGISSDFR YFEKKYYFEK 300
KARLAVDIFC HRLSKYIASY MSLMENNLDA IVFTGGIGEN VPLIREITLS 350
KLLLIGFKID TQRNLGIKNG KHGLITTDKS RPAFVIPTDE ELAIAQETIK 400
IIK 403
Length:403
Mass (Da):45,211
Last modified:October 1, 2002 - v1
Checksum:i408D7ABED18A8FA5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67736.1.
RefSeqiNP_660525.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67736; AAM67736; BUsg_169.
GeneIDi1005366.
KEGGibas:BUsg169.
PATRICi21247119. VBIBucAph100086_0173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67736.1 .
RefSeqi NP_660525.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8K9W6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg169.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67736 ; AAM67736 ; BUsg_169 .
GeneIDi 1005366.
KEGGi bas:BUsg169.
PATRICi 21247119. VBIBucAph100086_0173.

Phylogenomic databases

eggNOGi COG0282.
KOi K00925.
OMAi KYVTQRA.
OrthoDBi EOG69975F.

Enzyme and pathway databases

UniPathwayi UPA00340 ; UER00458 .
BioCyci BAPH198804:GHMG-178-MONOMER.

Family and domain databases

HAMAPi MF_00020. Acetate_kinase.
InterProi IPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view ]
PANTHERi PTHR21060. PTHR21060. 1 hit.
Pfami PF00871. Acetate_kinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSi PR00471. ACETATEKNASE.
TIGRFAMsi TIGR00016. ackA. 1 hit.
PROSITEi PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiACKA_BUCAP
AccessioniPrimary (citable) accession number: Q8K9W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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