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Q8K9W6

- ACKA_BUCAP

UniProt

Q8K9W6 - ACKA_BUCAP

Protein

Acetate kinase

Gene

ackA

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

    Catalytic activityi

    ATP + acetate = ADP + acetyl phosphate.UniRule annotation

    Cofactori

    Mg2+. Can also accept Mn2+.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi13 – 131MagnesiumUniRule annotation
    Binding sitei20 – 201ATPUniRule annotation
    Binding sitei94 – 941SubstrateUniRule annotation
    Active sitei153 – 1531Proton donor/acceptorUniRule annotation
    Sitei185 – 1851Transition state stabilizerUniRule annotation
    Sitei246 – 2461Transition state stabilizerUniRule annotation
    Metal bindingi390 – 3901MagnesiumUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi213 – 2175ATPUniRule annotation
    Nucleotide bindingi288 – 2903ATPUniRule annotation
    Nucleotide bindingi336 – 3405ATPUniRule annotation

    GO - Molecular functioni

    1. acetate kinase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-KW
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
    2. organic acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-178-MONOMER.
    UniPathwayiUPA00340; UER00458.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
    Alternative name(s):
    AcetokinaseUniRule annotation
    Gene namesi
    Name:ackAUniRule annotation
    Ordered Locus Names:BUsg_169
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 403403Acetate kinasePRO_0000107539Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi198804.BUsg169.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K9W6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetokinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0282.
    KOiK00925.
    OMAiKYVTQRA.
    OrthoDBiEOG69975F.

    Family and domain databases

    HAMAPiMF_00020. Acetate_kinase.
    InterProiIPR004372. Ac/Proprionate_kinase.
    IPR000890. Aliphatic_acid_kin_short-chain.
    IPR023865. Aliphatic_acid_kinase_CS.
    [Graphical view]
    PANTHERiPTHR21060. PTHR21060. 1 hit.
    PfamiPF00871. Acetate_kinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
    PRINTSiPR00471. ACETATEKNASE.
    TIGRFAMsiTIGR00016. ackA. 1 hit.
    PROSITEiPS01076. ACETATE_KINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K9W6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKILNNLIF VLNCGSSSVK FAILNPDNKK KYLSGLVECL FLSKTYMKWK    50
    DLTTEHKKCI GSNLSHKDAL NFIFNKFFLE KKDIYKNIVG IGHRVVHGGN 100
    KIKSSTLIDD NIIQLIQKAI SFAPLHNPAN LIGIKTAIEK FPIFAKKNVA 150
    VFDTSFYQNM PETSFLYAIP YFFYKEHHIR RYGAHGTSHH YVASEVALIL 200
    NKNFNSLNVI TCHLGNGASV SAVCNGICVD TSMGLTPLEG LVMGTRSGDI 250
    DPSIIFFMYQ KLGMSIDEIH TILTKESGLL GLSGISSDFR YFEKKYYFEK 300
    KARLAVDIFC HRLSKYIASY MSLMENNLDA IVFTGGIGEN VPLIREITLS 350
    KLLLIGFKID TQRNLGIKNG KHGLITTDKS RPAFVIPTDE ELAIAQETIK 400
    IIK 403
    Length:403
    Mass (Da):45,211
    Last modified:October 1, 2002 - v1
    Checksum:i408D7ABED18A8FA5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67736.1.
    RefSeqiNP_660525.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67736; AAM67736; BUsg_169.
    GeneIDi1005366.
    KEGGibas:BUsg169.
    PATRICi21247119. VBIBucAph100086_0173.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67736.1 .
    RefSeqi NP_660525.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8K9W6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg169.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67736 ; AAM67736 ; BUsg_169 .
    GeneIDi 1005366.
    KEGGi bas:BUsg169.
    PATRICi 21247119. VBIBucAph100086_0173.

    Phylogenomic databases

    eggNOGi COG0282.
    KOi K00925.
    OMAi KYVTQRA.
    OrthoDBi EOG69975F.

    Enzyme and pathway databases

    UniPathwayi UPA00340 ; UER00458 .
    BioCyci BAPH198804:GHMG-178-MONOMER.

    Family and domain databases

    HAMAPi MF_00020. Acetate_kinase.
    InterProi IPR004372. Ac/Proprionate_kinase.
    IPR000890. Aliphatic_acid_kin_short-chain.
    IPR023865. Aliphatic_acid_kinase_CS.
    [Graphical view ]
    PANTHERi PTHR21060. PTHR21060. 1 hit.
    Pfami PF00871. Acetate_kinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000722. Acetate_prop_kin. 1 hit.
    PRINTSi PR00471. ACETATEKNASE.
    TIGRFAMsi TIGR00016. ackA. 1 hit.
    PROSITEi PS01076. ACETATE_KINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiACKA_BUCAP
    AccessioniPrimary (citable) accession number: Q8K9W6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3