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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in acetate metabolism.By similarity

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathway:iacetyl-CoA biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA from acetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-179-MONOMER.
UniPathwayiUPA00340; UER00459.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:BUsg_170
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 709709Phosphate acetyltransferasePRO_0000179123Add
BLAST

Proteomic databases

PRIDEiQ8K9W5.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi198804.BUsg170.

Structurei

3D structure databases

ProteinModelPortaliQ8K9W5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni389 – 709321Phosphate acetyltransferaseAdd
BLAST

Domaini

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site (By similarity).By similarity

Sequence similaritiesi

In the N-terminal section; belongs to the CobB/CobQ family.Curated
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.Curated

Phylogenomic databases

eggNOGiCOG0280.
KOiK13788.
OMAiYSIANDN.
OrthoDBiEOG6BKJ5W.

Family and domain databases

Gene3Di3.40.1390.20. 1 hit.
InterProiIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N-like.
[Graphical view]
PfamiPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMiSSF75138. SSF75138. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K9W5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRIIMLIPL NKKVSLTTIS LSILYFFNKK EQKNCFKSFS YLPLIKSDNI
60 70 80 90 100
NFIRAYFSKK INVLDDINFF KKNFNSDEYS YLLDKIIKEC FNKKKINEFI
110 120 130 140 150
LIKGISRKEH DDADQINFDI AQNIDAEVIF IDNLKDFSLG CFKRKERKIN
160 170 180 190 200
VFLQQKKYKN FLGLIFSDIN SPFIFNKMKY NFFDKLIILK NTKKNTCIHA
210 220 230 240 250
IKKNIFFNSF FRVIAFIPWN KKLVKSSVIN IFKFLNATLV NTISIKDAFI
260 270 280 290 300
KNITIFDEDS SVILKKSYAN TLVLISSSRM ETFFKTLYLV CKSKKIGAIL
310 320 330 340 350
LTGVLKLSEN SIKLLKFLTN QGVPVFFIKE NTVETLSQLQ KFNFNINVQN
360 370 380 390 400
KYFINKLLEY TSSFFNKNHL ISLKKKTTNF YKKTYSPKEF CYRLKILSKS
410 420 430 440 450
KHKRIILPES YEPRILKAAS ICHRLGIAEC ILLGDPKKIY NIANENKIDL
460 470 480 490 500
NKNIEIKDPI LIRDQYVPRL LEIRKNKKID EIFARKQLKD NVILATLILE
510 520 530 540 550
SGKVDGLVSG TINTTANTIR PALQIIKTDP IYSLVSSIFF ILLPNEVLIY
560 570 580 590 600
GDCAINIEPN SKELAEIAIQ SANSAKMFGI EPRIAMLSYS TGFSGTGWQV
610 620 630 640 650
EKIRDATSIV KSKRPDLLID GPIQYDAAIS KEVAKLKIPY SSILGSANIF
660 670 680 690 700
IFPDLNSGNI TYKAVQRSAD LICIGPMLQG LKKPVNDLSR GASVEDIVYT

IALTSIQSL
Length:709
Mass (Da):81,236
Last modified:October 1, 2002 - v1
Checksum:iDF21DF13C0FC3FB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67737.1.
RefSeqiWP_011053704.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67737; AAM67737; BUsg_170.
KEGGibas:BUsg170.
PATRICi21247121. VBIBucAph100086_0174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67737.1.
RefSeqiWP_011053704.1. NC_004061.1.

3D structure databases

ProteinModelPortaliQ8K9W5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198804.BUsg170.

Proteomic databases

PRIDEiQ8K9W5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM67737; AAM67737; BUsg_170.
KEGGibas:BUsg170.
PATRICi21247121. VBIBucAph100086_0174.

Phylogenomic databases

eggNOGiCOG0280.
KOiK13788.
OMAiYSIANDN.
OrthoDBiEOG6BKJ5W.

Enzyme and pathway databases

UniPathwayiUPA00340; UER00459.
BioCyciBAPH198804:GHMG-179-MONOMER.

Family and domain databases

Gene3Di3.40.1390.20. 1 hit.
InterProiIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N-like.
[Graphical view]
PfamiPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMiSSF75138. SSF75138. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiPTA_BUCAP
AccessioniPrimary (citable) accession number: Q8K9W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: July 22, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.