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Q8K9W4

- RIR2_BUCAP

UniProt

Q8K9W4 - RIR2_BUCAP

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Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene
nrdB, BUsg_172
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Binds 2 iron ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi85 – 851Iron 1 By similarity
Metal bindingi116 – 1161Iron 1 By similarity
Metal bindingi116 – 1161Iron 2 By similarity
Metal bindingi119 – 1191Iron 1 By similarity
Active sitei123 – 1231 By similarity
Metal bindingi205 – 2051Iron 2 By similarity
Metal bindingi239 – 2391Iron 2 By similarity
Metal bindingi242 – 2421Iron 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-181-MONOMER.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdB
Ordered Locus Names:BUsg_172
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Ribonucleoside-diphosphate reductase subunit betaPRO_0000190471Add
BLAST

Proteomic databases

PRIDEiQ8K9W4.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits By similarity.

Protein-protein interaction databases

STRINGi198804.BUsg172.

Structurei

3D structure databases

ProteinModelPortaliQ8K9W4.
SMRiQ8K9W4. Positions 2-342.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
KOiK00526.
OMAiWIETWAF.
OrthoDBiEOG6J48J7.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 2 hits.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K9W4-1 [UniParc]FASTAAdd to Basket

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MSYTTFSKKK NNQLKEPMFF GQSVNIARYD QQKYNIFEKL IEKQLSFFWR    50
PEEIDLSKDR IDFDNLPSNE KHIFISNLKY QTLLDSIQGR SPNIAFLPIV 100
SIPELETWIE TWSFSETIHS RSYTHIIRNI INNPSIVFDD IISNKNINDR 150
AQDISIYYDE LIRITAYWHL LGEGNHKINE KKVEINLKLL KRRLYLCLIS 200
VNVLEAIRFY VSFACSFAFA EREIMEGNAK IIRLIARDEA LHLTGTQHIL 250
NILNNEKNNE NMKNTVLECR EEAIKIFISA SEQEKKWAKY LFQDGSMLGL 300
NKDILCQYIE YITNIRMHAI GFKMPFEKTS NPIPWINSWL NSDYIQAAPQ 350
ETEISSYLVG QIESEISNQE FKNFKL 376
Length:376
Mass (Da):44,225
Last modified:October 1, 2002 - v1
Checksum:i8C21C6FE1B85C74D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67738.1.
RefSeqiNP_660527.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67738; AAM67738; BUsg_172.
GeneIDi1005369.
KEGGibas:BUsg172.
PATRICi21247125. VBIBucAph100086_0176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67738.1 .
RefSeqi NP_660527.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8K9W4.
SMRi Q8K9W4. Positions 2-342.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg172.

Proteomic databases

PRIDEi Q8K9W4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67738 ; AAM67738 ; BUsg_172 .
GeneIDi 1005369.
KEGGi bas:BUsg172.
PATRICi 21247125. VBIBucAph100086_0176.

Phylogenomic databases

eggNOGi COG0208.
KOi K00526.
OMAi WIETWAF.
OrthoDBi EOG6J48J7.

Enzyme and pathway databases

UniPathwayi UPA00326 .
BioCyci BAPH198804:GHMG-181-MONOMER.

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 2 hits.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiRIR2_BUCAP
AccessioniPrimary (citable) accession number: Q8K9W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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