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Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdB

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi85Iron 1PROSITE-ProRule annotation1
Metal bindingi116Iron 1PROSITE-ProRule annotation1
Metal bindingi116Iron 2By similarity1
Metal bindingi119Iron 1PROSITE-ProRule annotation1
Active sitei123PROSITE-ProRule annotation1
Metal bindingi205Iron 2By similarity1
Metal bindingi239Iron 2By similarity1
Metal bindingi242Iron 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processDNA replication
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciBAPH198804:G1FZU-185-MONOMER
UniPathwayiUPA00326

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdB
Ordered Locus Names:BUsg_172
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000416 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001904711 – 376Ribonucleoside-diphosphate reductase subunit betaAdd BLAST376

Proteomic databases

PRIDEiQ8K9W4

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

STRINGi198804.BUsg172

Structurei

3D structure databases

ProteinModelPortaliQ8K9W4
SMRiQ8K9W4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105E05 Bacteria
COG0208 LUCA
KOiK00526
OMAiFYVGFVQ
OrthoDBiPOG091H04N9

Family and domain databases

CDDicd01049 RNRR2, 1 hit
Gene3Di1.10.620.20, 1 hit
InterProiView protein in InterPro
IPR009078 Ferritin-like_SF
IPR012348 RNR-like
IPR033909 RNR_small
IPR030475 RNR_small_AS
IPR000358 RNR_small_fam
PANTHERiPTHR23409 PTHR23409, 1 hit
PfamiView protein in Pfam
PF00268 Ribonuc_red_sm, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00368 RIBORED_SMALL, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K9W4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYTTFSKKK NNQLKEPMFF GQSVNIARYD QQKYNIFEKL IEKQLSFFWR
60 70 80 90 100
PEEIDLSKDR IDFDNLPSNE KHIFISNLKY QTLLDSIQGR SPNIAFLPIV
110 120 130 140 150
SIPELETWIE TWSFSETIHS RSYTHIIRNI INNPSIVFDD IISNKNINDR
160 170 180 190 200
AQDISIYYDE LIRITAYWHL LGEGNHKINE KKVEINLKLL KRRLYLCLIS
210 220 230 240 250
VNVLEAIRFY VSFACSFAFA EREIMEGNAK IIRLIARDEA LHLTGTQHIL
260 270 280 290 300
NILNNEKNNE NMKNTVLECR EEAIKIFISA SEQEKKWAKY LFQDGSMLGL
310 320 330 340 350
NKDILCQYIE YITNIRMHAI GFKMPFEKTS NPIPWINSWL NSDYIQAAPQ
360 370
ETEISSYLVG QIESEISNQE FKNFKL
Length:376
Mass (Da):44,225
Last modified:October 1, 2002 - v1
Checksum:i8C21C6FE1B85C74D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA Translation: AAM67738.1
RefSeqiWP_011053705.1, NC_004061.1

Genome annotation databases

EnsemblBacteriaiAAM67738; AAM67738; BUsg_172
KEGGibas:BUsg_172

Similar proteinsi

Entry informationi

Entry nameiRIR2_BUCAP
AccessioniPrimary (citable) accession number: Q8K9W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health