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Q8K9W4

- RIR2_BUCAP

UniProt

Q8K9W4 - RIR2_BUCAP

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Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdB

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi85 – 851Iron 1PROSITE-ProRule annotation
Metal bindingi116 – 1161Iron 1PROSITE-ProRule annotation
Metal bindingi116 – 1161Iron 2By similarity
Metal bindingi119 – 1191Iron 1PROSITE-ProRule annotation
Active sitei123 – 1231PROSITE-ProRule annotation
Metal bindingi205 – 2051Iron 2By similarity
Metal bindingi239 – 2391Iron 2By similarity
Metal bindingi242 – 2421Iron 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-181-MONOMER.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdB
Ordered Locus Names:BUsg_172
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Ribonucleoside-diphosphate reductase subunit betaPRO_0000190471Add
BLAST

Proteomic databases

PRIDEiQ8K9W4.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

STRINGi198804.BUsg172.

Structurei

3D structure databases

ProteinModelPortaliQ8K9W4.
SMRiQ8K9W4. Positions 2-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
KOiK00526.
OMAiWIETWAF.
OrthoDBiEOG6J48J7.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 2 hits.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K9W4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYTTFSKKK NNQLKEPMFF GQSVNIARYD QQKYNIFEKL IEKQLSFFWR
60 70 80 90 100
PEEIDLSKDR IDFDNLPSNE KHIFISNLKY QTLLDSIQGR SPNIAFLPIV
110 120 130 140 150
SIPELETWIE TWSFSETIHS RSYTHIIRNI INNPSIVFDD IISNKNINDR
160 170 180 190 200
AQDISIYYDE LIRITAYWHL LGEGNHKINE KKVEINLKLL KRRLYLCLIS
210 220 230 240 250
VNVLEAIRFY VSFACSFAFA EREIMEGNAK IIRLIARDEA LHLTGTQHIL
260 270 280 290 300
NILNNEKNNE NMKNTVLECR EEAIKIFISA SEQEKKWAKY LFQDGSMLGL
310 320 330 340 350
NKDILCQYIE YITNIRMHAI GFKMPFEKTS NPIPWINSWL NSDYIQAAPQ
360 370
ETEISSYLVG QIESEISNQE FKNFKL
Length:376
Mass (Da):44,225
Last modified:October 1, 2002 - v1
Checksum:i8C21C6FE1B85C74D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67738.1.
RefSeqiNP_660527.1. NC_004061.1.
WP_011053705.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67738; AAM67738; BUsg_172.
GeneIDi1005369.
KEGGibas:BUsg172.
PATRICi21247125. VBIBucAph100086_0176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67738.1 .
RefSeqi NP_660527.1. NC_004061.1.
WP_011053705.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8K9W4.
SMRi Q8K9W4. Positions 2-342.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg172.

Proteomic databases

PRIDEi Q8K9W4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67738 ; AAM67738 ; BUsg_172 .
GeneIDi 1005369.
KEGGi bas:BUsg172.
PATRICi 21247125. VBIBucAph100086_0176.

Phylogenomic databases

eggNOGi COG0208.
KOi K00526.
OMAi WIETWAF.
OrthoDBi EOG6J48J7.

Enzyme and pathway databases

UniPathwayi UPA00326 .
BioCyci BAPH198804:GHMG-181-MONOMER.

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 2 hits.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiRIR2_BUCAP
AccessioniPrimary (citable) accession number: Q8K9W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3