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Q8K9W4

- RIR2_BUCAP

UniProt

Q8K9W4 - RIR2_BUCAP

Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdB

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi85 – 851Iron 1PROSITE-ProRule annotation
    Metal bindingi116 – 1161Iron 1PROSITE-ProRule annotation
    Metal bindingi116 – 1161Iron 2By similarity
    Metal bindingi119 – 1191Iron 1PROSITE-ProRule annotation
    Active sitei123 – 1231PROSITE-ProRule annotation
    Metal bindingi205 – 2051Iron 2By similarity
    Metal bindingi239 – 2391Iron 2By similarity
    Metal bindingi242 – 2421Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-181-MONOMER.
    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase small subunit
    Gene namesi
    Name:nrdB
    Ordered Locus Names:BUsg_172
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Ribonucleoside-diphosphate reductase subunit betaPRO_0000190471Add
    BLAST

    Proteomic databases

    PRIDEiQ8K9W4.

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta subunits.By similarity

    Protein-protein interaction databases

    STRINGi198804.BUsg172.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K9W4.
    SMRiQ8K9W4. Positions 2-342.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0208.
    KOiK00526.
    OMAiWIETWAF.
    OrthoDBiEOG6J48J7.

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 2 hits.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00368. RIBORED_SMALL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K9W4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYTTFSKKK NNQLKEPMFF GQSVNIARYD QQKYNIFEKL IEKQLSFFWR    50
    PEEIDLSKDR IDFDNLPSNE KHIFISNLKY QTLLDSIQGR SPNIAFLPIV 100
    SIPELETWIE TWSFSETIHS RSYTHIIRNI INNPSIVFDD IISNKNINDR 150
    AQDISIYYDE LIRITAYWHL LGEGNHKINE KKVEINLKLL KRRLYLCLIS 200
    VNVLEAIRFY VSFACSFAFA EREIMEGNAK IIRLIARDEA LHLTGTQHIL 250
    NILNNEKNNE NMKNTVLECR EEAIKIFISA SEQEKKWAKY LFQDGSMLGL 300
    NKDILCQYIE YITNIRMHAI GFKMPFEKTS NPIPWINSWL NSDYIQAAPQ 350
    ETEISSYLVG QIESEISNQE FKNFKL 376
    Length:376
    Mass (Da):44,225
    Last modified:October 1, 2002 - v1
    Checksum:i8C21C6FE1B85C74D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67738.1.
    RefSeqiNP_660527.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67738; AAM67738; BUsg_172.
    GeneIDi1005369.
    KEGGibas:BUsg172.
    PATRICi21247125. VBIBucAph100086_0176.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67738.1 .
    RefSeqi NP_660527.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8K9W4.
    SMRi Q8K9W4. Positions 2-342.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg172.

    Proteomic databases

    PRIDEi Q8K9W4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67738 ; AAM67738 ; BUsg_172 .
    GeneIDi 1005369.
    KEGGi bas:BUsg172.
    PATRICi 21247125. VBIBucAph100086_0176.

    Phylogenomic databases

    eggNOGi COG0208.
    KOi K00526.
    OMAi WIETWAF.
    OrthoDBi EOG6J48J7.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .
    BioCyci BAPH198804:GHMG-181-MONOMER.

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00368. RIBORED_SMALL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiRIR2_BUCAP
    AccessioniPrimary (citable) accession number: Q8K9W4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3