Reviewed, UniProtKB/Swiss-Prot Q8K9V1 (THRC_BUCAP)

Names and origin

Protein names

Recommended name:
    Threonine synthase
    EC=4.2.3.1

Gene names

Name:	thrC
Ordered Locus Names:	BUsg_186

Organism

Buchnera aphidicola subsp. Schizaphis graminum [Complete proteome] [HAMAP]

Taxonomic identifier

98794 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	O-phospho-L-homoserine + H2O = L-threonine + phosphate.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.
Sequence similarities	Belongs to the serine/threonine dehydratase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro threonine synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 429	429	Threonine synthase		PRO_0000185628
Amino acid modifications
	Modified residue	108	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8K9V1-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 36AAB233D3C47BE6	FASTA	429	48,585
	10 20 30 40 50 60 MKLYNLKNHN EQVNFETAVK LGLGQKQGLF FPVKLPIMTP VELSKILKMD FITRSTEILS 70 80 90 100 110 120 KFISSEISKE VLHEHVKKAF SFSKPLKICI NKNISCFELF HGPTLAFKDF GARFMAQMIL 130 140 150 160 170 180 CLNKKNESFT ILTATSGDTG AAVAHAFYGM KNIRVIILYP KGKITLLQEQ LFCTLGKNIK 190 200 210 220 230 240 TISINGSFDD CQKLVKKAFD DKKLKESIGL NSANSINISR LLAQICYYFE AFSLISEEKR 250 260 270 280 290 300 KNLVIAVPCG NFGNLTAGLL AKSLGLPIQS FIACTNSNDT VPRFLNSGKW NPKKTVSTIS 310 320 330 340 350 360 NAMDISCPNN WPRIEELFRR KKWDLKELRF GSVSDNVTKE TLKELFRMGY VSEPHAAIAY 370 380 390 400 410 420 RLLHDQLKKE EFGLFLGTAH PSKFKDTVEK ILENSISLPK ELKNRNNLPL LSHNINPDFN KLKEFLLEK

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013218 Genomic DNA. Translation: AAM67751.1.
RefSeq	NP_660540.1.
3D structure databases
SMR	Q8K9V1. Positions 1-427.
ModBase	Search...
Genome annotation databases
GeneID	1005383.
GenomeReviews	Gene locus BUsg_186 in contig AE013218_GR.
KEGG	bas:BUsg186.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG521025.
OMA	VCYYFEA.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG186-MONOMER.
Family and domain databases
InterPro	IPR001926. PyrdxlP-dep_enz_bsu. IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. IPR004450. Thr_synthase. [Graphical view]
Pfam	PF00291. PALP. 1 hit. [Graphical view]
TIGRFAMs	TIGR00260. thrC. 1 hit.
PROSITE	PS00165. DEHYDRATASE_SER_THR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THRC_BUCAP

Accession

Primary (citable) accession number: Q8K9V1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	October 1, 2002
Last modified:	February 9, 2010
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)