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Protein

Threonine synthase

Gene

thrC

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactori

Pathway: L-threonine biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-threonine from L-aspartate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Bifunctional aspartokinase/homoserine dehydrogenase (thrA)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Bifunctional aspartokinase/homoserine dehydrogenase (thrA)
  4. Homoserine kinase (thrB)
  5. Threonine synthase (thrC)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-196-MONOMER.
UniPathwayiUPA00050; UER00065.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase (EC:4.2.3.1)
Short name:
TS
Gene namesi
Name:thrC
Ordered Locus Names:BUsg_186
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429Threonine synthasePRO_0000185628Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei108 – 1081N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PRIDEiQ8K9V1.

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg186.

Structurei

3D structure databases

ProteinModelPortaliQ8K9V1.
SMRiQ8K9V1. Positions 1-427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the threonine synthase family.Curated

Phylogenomic databases

eggNOGiCOG0498.
KOiK01733.
OMAiRRKNWQL.
OrthoDBiEOG65BDJX.

Family and domain databases

Gene3Di3.90.1380.10. 1 hit.
InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase_like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
PF14821. Thr_synth_N. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K9V1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLYNLKNHN EQVNFETAVK LGLGQKQGLF FPVKLPIMTP VELSKILKMD
60 70 80 90 100
FITRSTEILS KFISSEISKE VLHEHVKKAF SFSKPLKICI NKNISCFELF
110 120 130 140 150
HGPTLAFKDF GARFMAQMIL CLNKKNESFT ILTATSGDTG AAVAHAFYGM
160 170 180 190 200
KNIRVIILYP KGKITLLQEQ LFCTLGKNIK TISINGSFDD CQKLVKKAFD
210 220 230 240 250
DKKLKESIGL NSANSINISR LLAQICYYFE AFSLISEEKR KNLVIAVPCG
260 270 280 290 300
NFGNLTAGLL AKSLGLPIQS FIACTNSNDT VPRFLNSGKW NPKKTVSTIS
310 320 330 340 350
NAMDISCPNN WPRIEELFRR KKWDLKELRF GSVSDNVTKE TLKELFRMGY
360 370 380 390 400
VSEPHAAIAY RLLHDQLKKE EFGLFLGTAH PSKFKDTVEK ILENSISLPK
410 420
ELKNRNNLPL LSHNINPDFN KLKEFLLEK
Length:429
Mass (Da):48,585
Last modified:October 1, 2002 - v1
Checksum:i36AAB233D3C47BE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67751.1.
RefSeqiNP_660540.1. NC_004061.1.
WP_011053718.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67751; AAM67751; BUsg_186.
KEGGibas:BUsg186.
PATRICi21247155. VBIBucAph100086_0191.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67751.1.
RefSeqiNP_660540.1. NC_004061.1.
WP_011053718.1. NC_004061.1.

3D structure databases

ProteinModelPortaliQ8K9V1.
SMRiQ8K9V1. Positions 1-427.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198804.BUsg186.

Proteomic databases

PRIDEiQ8K9V1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM67751; AAM67751; BUsg_186.
KEGGibas:BUsg186.
PATRICi21247155. VBIBucAph100086_0191.

Phylogenomic databases

eggNOGiCOG0498.
KOiK01733.
OMAiRRKNWQL.
OrthoDBiEOG65BDJX.

Enzyme and pathway databases

UniPathwayiUPA00050; UER00065.
BioCyciBAPH198804:GHMG-196-MONOMER.

Family and domain databases

Gene3Di3.90.1380.10. 1 hit.
InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR029144. Thr_synth_N.
IPR004450. Thr_synthase_like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
PF14821. Thr_synth_N. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiTHRC_BUCAP
AccessioniPrimary (citable) accession number: Q8K9V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: April 29, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.