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Q8K9V0 (KHSE_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homoserine kinase

Short name=HK
Short name=HSK
EC=2.7.1.39
Gene names
Name:thrB
Ordered Locus Names:BUsg_187
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP-Rule MF_00384

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP-Rule MF_00384

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP-Rule MF_00384

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00384.

Sequence similarities

Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processthreonine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

homoserine kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Homoserine kinase HAMAP-Rule MF_00384
PRO_0000156556

Regions

Nucleotide binding91 – 10111ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q8K9V0 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 76118A4C8CD1C3D3

FASTA30934,036
        10         20         30         40         50         60 
MIKIYAPASV ANVGVGFDIL GAAIIPINGT LLGDCVTVKL SKKFELINKG IFSNKLPINK 

        70         80         90        100        110        120 
EQNIVWKCWF KFCKVIKKNI PVSIILEKNM PIGSGLGSSA CSVVATLVAI NQICNNPLNS 

       130        140        150        160        170        180 
KELLLLMGEI EGEISGSIHY DNVAPSYLGG LQLILEDSDI ISQKIPNFKH WFWIIAWPGI 

       190        200        210        220        230        240 
KVSTAEARKI LPKEYKKDIC IKNSRYLAGF IHASYTKQSH LAARCMQDFI AEPYRSKLLP 

       250        260        270        280        290        300 
NFLNAKEKIK KIGAISCGIS GSGPTIFAIS DKIKTAEKIS LWLKNNYLQN KTGFVHICAV 


DVKGVRKIG 

« Hide

References

[1]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE013218 Genomic DNA. Translation: AAM67752.1.
RefSeqNP_660541.1. NC_004061.1.

3D structure databases

ProteinModelPortalQ8K9V0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198804.BUsg187.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM67752; AAM67752; BUsg_187.
GeneID1005384.
KEGGbas:BUsg187.
PATRIC21247157. VBIBucAph100086_0192.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0083.
KOK00872.
OMANVACGFD.
OrthoDBEOG6DG2WK.
ProtClustDBPRK01212.

Enzyme and pathway databases

BioCycBAPH198804:GHMG-197-MONOMER.
UniPathwayUPA00050; UER00064.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPMF_00384. Homoser_kinase.
InterProIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
SUPFAMSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsTIGR00191. thrB. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKHSE_BUCAP
AccessionPrimary (citable) accession number: Q8K9V0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names