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Q8K9V0

- KHSE_BUCAP

UniProt

Q8K9V0 - KHSE_BUCAP

Protein

Homoserine kinase

Gene

thrB

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.UniRule annotation

    Catalytic activityi

    ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi91 – 10111ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. homoserine kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. threonine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Threonine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-197-MONOMER.
    UniPathwayiUPA00050; UER00064.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)
    Short name:
    HKUniRule annotation
    Short name:
    HSKUniRule annotation
    Gene namesi
    Name:thrBUniRule annotation
    Ordered Locus Names:BUsg_187
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Homoserine kinasePRO_0000156556Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi198804.BUsg187.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K9V0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GHMP kinase family. Homoserine kinase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0083.
    KOiK00872.
    OMAiHIANEGT.
    OrthoDBiEOG6DG2WK.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPiMF_00384. Homoser_kinase.
    InterProiIPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR006203. GHMP_knse_ATP-bd_CS.
    IPR000870. Homoserine_kinase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view]
    PfamiPF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000676. Homoser_kin. 1 hit.
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsiTIGR00191. thrB. 1 hit.
    PROSITEiPS00627. GHMP_KINASES_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K9V0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKIYAPASV ANVGVGFDIL GAAIIPINGT LLGDCVTVKL SKKFELINKG    50
    IFSNKLPINK EQNIVWKCWF KFCKVIKKNI PVSIILEKNM PIGSGLGSSA 100
    CSVVATLVAI NQICNNPLNS KELLLLMGEI EGEISGSIHY DNVAPSYLGG 150
    LQLILEDSDI ISQKIPNFKH WFWIIAWPGI KVSTAEARKI LPKEYKKDIC 200
    IKNSRYLAGF IHASYTKQSH LAARCMQDFI AEPYRSKLLP NFLNAKEKIK 250
    KIGAISCGIS GSGPTIFAIS DKIKTAEKIS LWLKNNYLQN KTGFVHICAV 300
    DVKGVRKIG 309
    Length:309
    Mass (Da):34,036
    Last modified:October 1, 2002 - v1
    Checksum:i76118A4C8CD1C3D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67752.1.
    RefSeqiNP_660541.1. NC_004061.1.
    WP_011053719.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67752; AAM67752; BUsg_187.
    GeneIDi1005384.
    KEGGibas:BUsg187.
    PATRICi21247157. VBIBucAph100086_0192.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67752.1 .
    RefSeqi NP_660541.1. NC_004061.1.
    WP_011053719.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8K9V0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg187.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67752 ; AAM67752 ; BUsg_187 .
    GeneIDi 1005384.
    KEGGi bas:BUsg187.
    PATRICi 21247157. VBIBucAph100086_0192.

    Phylogenomic databases

    eggNOGi COG0083.
    KOi K00872.
    OMAi HIANEGT.
    OrthoDBi EOG6DG2WK.

    Enzyme and pathway databases

    UniPathwayi UPA00050 ; UER00064 .
    BioCyci BAPH198804:GHMG-197-MONOMER.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPi MF_00384. Homoser_kinase.
    InterProi IPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR006203. GHMP_knse_ATP-bd_CS.
    IPR000870. Homoserine_kinase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view ]
    Pfami PF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000676. Homoser_kin. 1 hit.
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsi TIGR00191. thrB. 1 hit.
    PROSITEi PS00627. GHMP_KINASES_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiKHSE_BUCAP
    AccessioniPrimary (citable) accession number: Q8K9V0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3