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Q8K9U8

- HPRT_BUCAP

UniProt

Q8K9U8 - HPRT_BUCAP

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Protein
Hypoxanthine phosphoribosyltransferase
Gene
hpt, BUsg_189
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine By similarity.

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.

Cofactori

Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei103 – 1031Proton acceptor By similarity
Binding sitei131 – 1311IMP By similarity
Metal bindingi159 – 1591Magnesium By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi99 – 10810IMP By similarity
Nucleotide bindingi158 – 1592IMP By similarity

GO - Molecular functioni

  1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
  2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
  4. nucleotide binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. IMP salvage Source: UniProtKB-UniPathway
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Keywords - Ligandi

Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-199-MONOMER.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine phosphoribosyltransferase (EC:2.4.2.8)
Short name:
HPRT
Gene namesi
Name:hpt
Ordered Locus Names:BUsg_189
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177Hypoxanthine phosphoribosyltransferase
PRO_0000139631Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg189.

Structurei

3D structure databases

ProteinModelPortaliQ8K9U8.
SMRiQ8K9U8. Positions 1-175.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0634.
KOiK00760.
OMAiVDFMTVS.
OrthoDBiEOG693GNP.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
InterProiIPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01203. HGPRTase. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K9U8-1 [UniParc]FASTAAdd to Basket

« Hide

MKHTIKVIIS EKELDIRVRE LGEEITKKYK NSKNKIILIA LLRGSFVFIA    50
DLCRRIKIEH EIDFMTTSSY GRGMISTGDV KIIKDLDEDI YNKNVLIVED 100
IIDSGKTLSK VLGILKLRNP KSLSICTLLD KPECREVNIN IDFVGFSIPD 150
EFMVGYGIDY AQSYRYLPYI GKVIFKK 177
Length:177
Mass (Da):20,342
Last modified:October 1, 2002 - v1
Checksum:iA5311913399CDB2B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67754.1.
RefSeqiNP_660543.1. NC_004061.1.
WP_011053721.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67754; AAM67754; BUsg_189.
GeneIDi1005386.
KEGGibas:BUsg189.
PATRICi21247161. VBIBucAph100086_0194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67754.1 .
RefSeqi NP_660543.1. NC_004061.1.
WP_011053721.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8K9U8.
SMRi Q8K9U8. Positions 1-175.
ModBasei Search...

Protein-protein interaction databases

STRINGi 198804.BUsg189.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67754 ; AAM67754 ; BUsg_189 .
GeneIDi 1005386.
KEGGi bas:BUsg189.
PATRICi 21247161. VBIBucAph100086_0194.

Phylogenomic databases

eggNOGi COG0634.
KOi K00760.
OMAi VDFMTVS.
OrthoDBi EOG693GNP.

Enzyme and pathway databases

UniPathwayi UPA00591 ; UER00648 .
BioCyci BAPH198804:GHMG-199-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
InterProi IPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
TIGRFAMsi TIGR01203. HGPRTase. 1 hit.
PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiHPRT_BUCAP
AccessioniPrimary (citable) accession number: Q8K9U8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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