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Q8K9U3 (SECA_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein translocase subunit SecA
Gene names
Name:secA
Ordered Locus Names:BUsg_195
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length874 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane By similarity. HAMAP-Rule MF_01382

Cofactor

May bind 1 zinc ion per subunit Potential.

Subunit structure

Monomer and homodimer By similarity. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC By similarity. HAMAP-Rule MF_01382

Subcellular location

Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm By similarity. Note: Distribution is 50-50 By similarity. HAMAP-Rule MF_01382

Sequence similarities

Belongs to the SecA family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 874874Protein translocase subunit SecA HAMAP-Rule MF_01382
PRO_0000109579

Regions

Nucleotide binding102 – 1098ATP Potential

Sites

Metal binding8591Zinc Potential
Metal binding8611Zinc Potential
Metal binding8701Zinc Potential
Metal binding8711Zinc Potential

Sequences

Sequence LengthMass (Da)Tools
Q8K9U3 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: BC49815F42051791

FASTA874101,164
        10         20         30         40         50         60 
MFIKFLHKIF SNRNDRILKK FKKIVSSINQ LEEKFKKLSD KKLQENTGIF RLRLKKGECL 

        70         80         90        100        110        120 
DDLLPESFAT VREASRRVFN MRHFDVQILG GIVLNKQCIA EMRTGEGKTL TSTLPAYLNA 

       130        140        150        160        170        180 
LTGRGVHIVT MNDYLAERDA KNNTPLFEFL GLTVGLNLPE MSFIDKKKAY LCDITYGTNN 

       190        200        210        220        230        240 
EYGFDYLRDN MIFSAEERVQ RELNYALIDE VDSILIDEAR TPLIISGPSE DSSFLYKEIN 

       250        260        270        280        290        300 
KLVPSLICQK KEDSDKFHGN GHFSIDEKSK QIYLTERGLV EVEKILLDRK LMKKEESLYS 

       310        320        330        340        350        360 
SNNIILMHHV ISALRAHNLF TRNIDYLVKD NNIIIVDEHT GRTMPGRRWS DGLHQAIEAK 

       370        380        390        400        410        420 
ENVTVRNENQ TLASITFQNY FRLYKKIAGM TGTAATESFE FSSIYNLDTV IIPPNKPMIR 

       430        440        450        460        470        480 
KDLSDLVYMT EEEKINAILK DIKNCIKKNQ PVLVGTISIE KSEMISKKLK ILNIKHNVLN 

       490        500        510        520        530        540 
AKFHAREAEI IAQAGKPKSV TIATNMAGRG TDIVLGGSLE SQLEKNMYLD KIETIKRNWK 

       550        560        570        580        590        600 
KQHDLVVLSG GLHIIGTERH ESRRIDNQLR GRSGRQGDSG SSRFYLSMED SLMRIFASDK 

       610        620        630        640        650        660 
IISMMRKLGL SLNEAIEHPW VTKAIENAQK KVENRNFDIR KQLLEYDDVC NEQRRVIYAQ 

       670        680        690        700        710        720 
RNKLIDSENI QQNIYDILKD VLHSIIKTHL NFDFPKNTRN ILDLENKLSI EFNLNISIKD 

       730        740        750        760        770        780 
WLKKDHDIKK ENIIKKIIDI AKKNYLNKEI QIGFHNIRMI EKSIMLKTLD SLWKEHLSAM 

       790        800        810        820        830        840 
DYLRQGIHLR GYAQKDPKQE YKRESFNMFS NMLELLKYEV ISFLSKLDIS YIKSNLHLNM 

       850        860        870 
NNNSSIVNND IKMGRNTPCF CKSGKKYKYC HGSL 

« Hide

References

[1]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE013218 Genomic DNA. Translation: AAM67759.1.
RefSeqNP_660548.1. NC_004061.1.

3D structure databases

ProteinModelPortalQ8K9U3.
SMRQ8K9U3. Positions 9-829.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198804.BUsg195.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM67759; AAM67759; BUsg_195.
GeneID1005392.
KEGGbas:BUsg195.
PATRIC21247177. VBIBucAph100086_0202.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0653.
KOK03070.
OMAEFQEIYG.
OrthoDBEOG654P48.
ProtClustDBPRK12904.

Enzyme and pathway databases

BioCycBAPH198804:GHMG-205-MONOMER.

Family and domain databases

Gene3D1.10.3060.10. 1 hit.
3.90.1440.10. 1 hit.
HAMAPMF_01382. SecA.
InterProIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSPR00906. SECA.
SMARTSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsTIGR00963. secA. 1 hit.
PROSITEPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSECA_BUCAP
AccessionPrimary (citable) accession number: Q8K9U3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: February 19, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names