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Q8K9U3

- SECA_BUCAP

UniProt

Q8K9U3 - SECA_BUCAP

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Protein
Protein translocase subunit SecA
Gene
secA, BUsg_195
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane By similarity.UniRule annotation

Cofactori

May bind 1 zinc ion per subunit Reviewed prediction.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi859 – 8591Zinc Reviewed prediction
Metal bindingi861 – 8611Zinc Reviewed prediction
Metal bindingi870 – 8701Zinc Reviewed prediction
Metal bindingi871 – 8711Zinc Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi102 – 1098ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
  2. protein import Source: InterPro
  3. protein targeting Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-205-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecA
Gene namesi
Name:secA
Ordered Locus Names:BUsg_195
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

Subcellular locationi

Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasm By similarity
Note: Distribution is 50-50 By similarity.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 874874Protein translocase subunit SecAUniRule annotation
PRO_0000109579Add
BLAST

Interactioni

Subunit structurei

Monomer and homodimer By similarity. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi198804.BUsg195.

Structurei

3D structure databases

ProteinModelPortaliQ8K9U3.
SMRiQ8K9U3. Positions 9-829.

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.

Phylogenomic databases

eggNOGiCOG0653.
KOiK03070.
OMAiEAYEFQQ.
OrthoDBiEOG654P48.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K9U3-1 [UniParc]FASTAAdd to Basket

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MFIKFLHKIF SNRNDRILKK FKKIVSSINQ LEEKFKKLSD KKLQENTGIF    50
RLRLKKGECL DDLLPESFAT VREASRRVFN MRHFDVQILG GIVLNKQCIA 100
EMRTGEGKTL TSTLPAYLNA LTGRGVHIVT MNDYLAERDA KNNTPLFEFL 150
GLTVGLNLPE MSFIDKKKAY LCDITYGTNN EYGFDYLRDN MIFSAEERVQ 200
RELNYALIDE VDSILIDEAR TPLIISGPSE DSSFLYKEIN KLVPSLICQK 250
KEDSDKFHGN GHFSIDEKSK QIYLTERGLV EVEKILLDRK LMKKEESLYS 300
SNNIILMHHV ISALRAHNLF TRNIDYLVKD NNIIIVDEHT GRTMPGRRWS 350
DGLHQAIEAK ENVTVRNENQ TLASITFQNY FRLYKKIAGM TGTAATESFE 400
FSSIYNLDTV IIPPNKPMIR KDLSDLVYMT EEEKINAILK DIKNCIKKNQ 450
PVLVGTISIE KSEMISKKLK ILNIKHNVLN AKFHAREAEI IAQAGKPKSV 500
TIATNMAGRG TDIVLGGSLE SQLEKNMYLD KIETIKRNWK KQHDLVVLSG 550
GLHIIGTERH ESRRIDNQLR GRSGRQGDSG SSRFYLSMED SLMRIFASDK 600
IISMMRKLGL SLNEAIEHPW VTKAIENAQK KVENRNFDIR KQLLEYDDVC 650
NEQRRVIYAQ RNKLIDSENI QQNIYDILKD VLHSIIKTHL NFDFPKNTRN 700
ILDLENKLSI EFNLNISIKD WLKKDHDIKK ENIIKKIIDI AKKNYLNKEI 750
QIGFHNIRMI EKSIMLKTLD SLWKEHLSAM DYLRQGIHLR GYAQKDPKQE 800
YKRESFNMFS NMLELLKYEV ISFLSKLDIS YIKSNLHLNM NNNSSIVNND 850
IKMGRNTPCF CKSGKKYKYC HGSL 874
Length:874
Mass (Da):101,164
Last modified:October 1, 2002 - v1
Checksum:iBC49815F42051791
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67759.1.
RefSeqiNP_660548.1. NC_004061.1.
WP_011053726.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67759; AAM67759; BUsg_195.
GeneIDi1005392.
KEGGibas:BUsg195.
PATRICi21247177. VBIBucAph100086_0202.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67759.1 .
RefSeqi NP_660548.1. NC_004061.1.
WP_011053726.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8K9U3.
SMRi Q8K9U3. Positions 9-829.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg195.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67759 ; AAM67759 ; BUsg_195 .
GeneIDi 1005392.
KEGGi bas:BUsg195.
PATRICi 21247177. VBIBucAph100086_0202.

Phylogenomic databases

eggNOGi COG0653.
KOi K03070.
OMAi EAYEFQQ.
OrthoDBi EOG654P48.

Enzyme and pathway databases

BioCyci BAPH198804:GHMG-205-MONOMER.

Family and domain databases

Gene3Di 1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPi MF_01382. SecA.
InterProi IPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view ]
Pfami PF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view ]
PRINTSi PR00906. SECA.
SMARTi SM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsi TIGR00963. secA. 1 hit.
PROSITEi PS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiSECA_BUCAP
AccessioniPrimary (citable) accession number: Q8K9U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi