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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: May bind 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi859ZincUniRule annotation1
Metal bindingi861ZincUniRule annotation1
Metal bindingi870ZincUniRule annotation1
Metal bindingi871ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi102 – 109ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciBAPH198804:G1FZU-209-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:BUsg_195
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000416 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation
  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001095791 – 874Protein translocase subunit SecAAdd BLAST874

Proteomic databases

PRIDEiQ8K9U3

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.UniRule annotation

Protein-protein interaction databases

STRINGi198804.BUsg195

Structurei

3D structure databases

ProteinModelPortaliQ8K9U3
SMRiQ8K9U3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI6 Bacteria
COG0653 LUCA
KOiK03070
OMAiFEYDEVM
OrthoDBiPOG091H01RS

Family and domain databases

HAMAPiMF_01382 SecA, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR004027 SEC_C_motif
IPR000185 SecA
IPR020937 SecA_CS
IPR011115 SecA_DEAD
IPR014018 SecA_motor_DEAD
IPR011130 SecA_preprotein_X-link_dom
IPR011116 SecA_Wing/Scaffold
IPR036266 SecA_Wing/Scaffold_sf
IPR036670 SecA_X-link_sf
PANTHERiPTHR30612 PTHR30612, 1 hit
PfamiView protein in Pfam
PF02810 SEC-C, 1 hit
PF07517 SecA_DEAD, 1 hit
PF01043 SecA_PP_bind, 1 hit
PF07516 SecA_SW, 1 hit
PRINTSiPR00906 SECA
SMARTiView protein in SMART
SM00957 SecA_DEAD, 1 hit
SM00958 SecA_PP_bind, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
SSF81767 SSF81767, 1 hit
SSF81886 SSF81886, 1 hit
TIGRFAMsiTIGR00963 secA, 1 hit
PROSITEiView protein in PROSITE
PS01312 SECA, 1 hit
PS51196 SECA_MOTOR_DEAD, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K9U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIKFLHKIF SNRNDRILKK FKKIVSSINQ LEEKFKKLSD KKLQENTGIF
60 70 80 90 100
RLRLKKGECL DDLLPESFAT VREASRRVFN MRHFDVQILG GIVLNKQCIA
110 120 130 140 150
EMRTGEGKTL TSTLPAYLNA LTGRGVHIVT MNDYLAERDA KNNTPLFEFL
160 170 180 190 200
GLTVGLNLPE MSFIDKKKAY LCDITYGTNN EYGFDYLRDN MIFSAEERVQ
210 220 230 240 250
RELNYALIDE VDSILIDEAR TPLIISGPSE DSSFLYKEIN KLVPSLICQK
260 270 280 290 300
KEDSDKFHGN GHFSIDEKSK QIYLTERGLV EVEKILLDRK LMKKEESLYS
310 320 330 340 350
SNNIILMHHV ISALRAHNLF TRNIDYLVKD NNIIIVDEHT GRTMPGRRWS
360 370 380 390 400
DGLHQAIEAK ENVTVRNENQ TLASITFQNY FRLYKKIAGM TGTAATESFE
410 420 430 440 450
FSSIYNLDTV IIPPNKPMIR KDLSDLVYMT EEEKINAILK DIKNCIKKNQ
460 470 480 490 500
PVLVGTISIE KSEMISKKLK ILNIKHNVLN AKFHAREAEI IAQAGKPKSV
510 520 530 540 550
TIATNMAGRG TDIVLGGSLE SQLEKNMYLD KIETIKRNWK KQHDLVVLSG
560 570 580 590 600
GLHIIGTERH ESRRIDNQLR GRSGRQGDSG SSRFYLSMED SLMRIFASDK
610 620 630 640 650
IISMMRKLGL SLNEAIEHPW VTKAIENAQK KVENRNFDIR KQLLEYDDVC
660 670 680 690 700
NEQRRVIYAQ RNKLIDSENI QQNIYDILKD VLHSIIKTHL NFDFPKNTRN
710 720 730 740 750
ILDLENKLSI EFNLNISIKD WLKKDHDIKK ENIIKKIIDI AKKNYLNKEI
760 770 780 790 800
QIGFHNIRMI EKSIMLKTLD SLWKEHLSAM DYLRQGIHLR GYAQKDPKQE
810 820 830 840 850
YKRESFNMFS NMLELLKYEV ISFLSKLDIS YIKSNLHLNM NNNSSIVNND
860 870
IKMGRNTPCF CKSGKKYKYC HGSL
Length:874
Mass (Da):101,164
Last modified:October 1, 2002 - v1
Checksum:iBC49815F42051791
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA Translation: AAM67759.1
RefSeqiWP_011053726.1, NC_004061.1

Genome annotation databases

EnsemblBacteriaiAAM67759; AAM67759; BUsg_195
KEGGibas:BUsg_195

Similar proteinsi

Entry informationi

Entry nameiSECA_BUCAP
AccessioniPrimary (citable) accession number: Q8K9U3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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