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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: May bind 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi859 – 8591ZincUniRule annotation
Metal bindingi861 – 8611ZincUniRule annotation
Metal bindingi870 – 8701ZincUniRule annotation
Metal bindingi871 – 8711ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi102 – 1098ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-205-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:BUsg_195
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation

  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 874874Protein translocase subunit SecAPRO_0000109579Add
BLAST

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.UniRule annotation

Protein-protein interaction databases

STRINGi198804.BUsg195.

Structurei

3D structure databases

ProteinModelPortaliQ8K9U3.
SMRiQ8K9U3. Positions 9-829.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0653.
KOiK03070.
OMAiIATERHE.
OrthoDBiEOG654P48.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K9U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIKFLHKIF SNRNDRILKK FKKIVSSINQ LEEKFKKLSD KKLQENTGIF
60 70 80 90 100
RLRLKKGECL DDLLPESFAT VREASRRVFN MRHFDVQILG GIVLNKQCIA
110 120 130 140 150
EMRTGEGKTL TSTLPAYLNA LTGRGVHIVT MNDYLAERDA KNNTPLFEFL
160 170 180 190 200
GLTVGLNLPE MSFIDKKKAY LCDITYGTNN EYGFDYLRDN MIFSAEERVQ
210 220 230 240 250
RELNYALIDE VDSILIDEAR TPLIISGPSE DSSFLYKEIN KLVPSLICQK
260 270 280 290 300
KEDSDKFHGN GHFSIDEKSK QIYLTERGLV EVEKILLDRK LMKKEESLYS
310 320 330 340 350
SNNIILMHHV ISALRAHNLF TRNIDYLVKD NNIIIVDEHT GRTMPGRRWS
360 370 380 390 400
DGLHQAIEAK ENVTVRNENQ TLASITFQNY FRLYKKIAGM TGTAATESFE
410 420 430 440 450
FSSIYNLDTV IIPPNKPMIR KDLSDLVYMT EEEKINAILK DIKNCIKKNQ
460 470 480 490 500
PVLVGTISIE KSEMISKKLK ILNIKHNVLN AKFHAREAEI IAQAGKPKSV
510 520 530 540 550
TIATNMAGRG TDIVLGGSLE SQLEKNMYLD KIETIKRNWK KQHDLVVLSG
560 570 580 590 600
GLHIIGTERH ESRRIDNQLR GRSGRQGDSG SSRFYLSMED SLMRIFASDK
610 620 630 640 650
IISMMRKLGL SLNEAIEHPW VTKAIENAQK KVENRNFDIR KQLLEYDDVC
660 670 680 690 700
NEQRRVIYAQ RNKLIDSENI QQNIYDILKD VLHSIIKTHL NFDFPKNTRN
710 720 730 740 750
ILDLENKLSI EFNLNISIKD WLKKDHDIKK ENIIKKIIDI AKKNYLNKEI
760 770 780 790 800
QIGFHNIRMI EKSIMLKTLD SLWKEHLSAM DYLRQGIHLR GYAQKDPKQE
810 820 830 840 850
YKRESFNMFS NMLELLKYEV ISFLSKLDIS YIKSNLHLNM NNNSSIVNND
860 870
IKMGRNTPCF CKSGKKYKYC HGSL
Length:874
Mass (Da):101,164
Last modified:October 1, 2002 - v1
Checksum:iBC49815F42051791
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67759.1.
RefSeqiWP_011053726.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67759; AAM67759; BUsg_195.
KEGGibas:BUsg195.
PATRICi21247177. VBIBucAph100086_0202.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67759.1.
RefSeqiWP_011053726.1. NC_004061.1.

3D structure databases

ProteinModelPortaliQ8K9U3.
SMRiQ8K9U3. Positions 9-829.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198804.BUsg195.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM67759; AAM67759; BUsg_195.
KEGGibas:BUsg195.
PATRICi21247177. VBIBucAph100086_0202.

Phylogenomic databases

eggNOGiCOG0653.
KOiK03070.
OMAiIATERHE.
OrthoDBiEOG654P48.

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-205-MONOMER.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiSECA_BUCAP
AccessioniPrimary (citable) accession number: Q8K9U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: July 22, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.