Q8K9U1 (COAE_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dephospho-CoA kinase
EC=2.7.1.24

Alternative name(s):
Dephosphocoenzyme A kinase

Gene names

Name:	coaE
Ordered Locus Names:	BUsg_197

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Schizaphis graminum)

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A By similarity. HAMAP-Rule MF_00376
Catalytic activity	ATP + 3'-dephospho-CoA = ADP + CoA. HAMAP-Rule MF_00376
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. HAMAP-Rule MF_00376
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the CoaE family. Contains 1 DPCK (dephospho-CoA kinase) domain.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP dephospho-CoA kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Dephospho-CoA kinase HAMAP-Rule MF_00376		PRO_0000172920
Regions
	Domain	4 – 201	198	DPCK
	Nucleotide binding	9 – 16	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8K9U1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 13B5614106473FCD	FASTA	210	24,892
	10 20 30 40 50 60 MIYIVALTGG ICSGKTTVSD RFKKIGINVI DTDVIGRKII EKNKKISDSI KKKFGKKILN 70 80 90 100 110 120 KDNSINRFLL RNCIFNEKKS RLWLENILHP EILKKSKKKI KLIQSTWCLW VVPLLFEKKI 130 140 150 160 170 180 QKKANRILLI DTPIRIQIRR MIKRDKININ EAKKIISYQV RRKKRISLSD DIILNKNKNI 190 200 210 EKLSLYIHYL NNFYIYLSKQ NNPKNMKKII

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013218 Genomic DNA. Translation: AAM67761.1.
RefSeq	NP_660550.1. NC_004061.1.
3D structure databases
ProteinModelPortal	Q8K9U1.
ModBase	Search...
Protein-protein interaction databases
STRING	198804.BUsg197.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM67761; AAM67761; BUsg_197.
GeneID	1005394.
KEGG	bas:BUsg197.
PATRIC	21247181. VBIBucAph100086_0204.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0237.
KO	K00859.
OMA	QRLACQM.
ProtClustDB	CLSK315784.
Enzyme and pathway databases
BioCyc	BAPH198804:GHMG-263-MONOMER.
UniPathway	UPA00241; UER00356.
Family and domain databases
HAMAP	MF_00376. Dephospho_CoA_kinase.
InterPro	IPR001977. Depp_CoAkinase. [Graphical view]
Pfam	PF01121. CoaE. 1 hit. [Graphical view]
TIGRFAMs	TIGR00152. TIGR00152. 1 hit.
PROSITE	PS51219. DPCK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COAE_BUCAP

Accession

Primary (citable) accession number: Q8K9U1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program