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Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.UniRule annotation

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.UniRule annotation

Pathway: coenzyme A biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-207-MONOMER.
UniPathwayiUPA00241; UER00356.

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinaseUniRule annotation (EC:2.7.1.24UniRule annotation)
Alternative name(s):
Dephosphocoenzyme A kinaseUniRule annotation
Gene namesi
Name:coaEUniRule annotation
Ordered Locus Names:BUsg_197
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Dephospho-CoA kinasePRO_0000172920Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg197.

Structurei

3D structure databases

ProteinModelPortaliQ8K9U1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 201198DPCKUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CoaE family.UniRule annotation
Contains 1 DPCK (dephospho-CoA kinase) domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0237.
KOiK00859.
OMAiNANELKW.
OrthoDBiEOG6HTP3H.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K9U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYIVALTGG ICSGKTTVSD RFKKIGINVI DTDVIGRKII EKNKKISDSI
60 70 80 90 100
KKKFGKKILN KDNSINRFLL RNCIFNEKKS RLWLENILHP EILKKSKKKI
110 120 130 140 150
KLIQSTWCLW VVPLLFEKKI QKKANRILLI DTPIRIQIRR MIKRDKININ
160 170 180 190 200
EAKKIISYQV RRKKRISLSD DIILNKNKNI EKLSLYIHYL NNFYIYLSKQ
210
NNPKNMKKII
Length:210
Mass (Da):24,892
Last modified:October 1, 2002 - v1
Checksum:i13B5614106473FCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67761.1.
RefSeqiNP_660550.1. NC_004061.1.
WP_011053728.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67761; AAM67761; BUsg_197.
KEGGibas:BUsg197.
PATRICi21247181. VBIBucAph100086_0204.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67761.1.
RefSeqiNP_660550.1. NC_004061.1.
WP_011053728.1. NC_004061.1.

3D structure databases

ProteinModelPortaliQ8K9U1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198804.BUsg197.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM67761; AAM67761; BUsg_197.
KEGGibas:BUsg197.
PATRICi21247181. VBIBucAph100086_0204.

Phylogenomic databases

eggNOGiCOG0237.
KOiK00859.
OMAiNANELKW.
OrthoDBiEOG6HTP3H.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00356.
BioCyciBAPH198804:GHMG-207-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiCOAE_BUCAP
AccessioniPrimary (citable) accession number: Q8K9U1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: May 27, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.