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Protein

Pyruvate dehydrogenase E1 component

Gene

aceE

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-209-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component (EC:1.2.4.1)
Short name:
PDH E1 component
Gene namesi
Name:aceE
Ordered Locus Names:BUsg_199
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 888888Pyruvate dehydrogenase E1 componentPRO_0000162241Add
BLAST

Proteomic databases

PRIDEiQ8K9T9.

Interactioni

Subunit structurei

Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).By similarity

Protein-protein interaction databases

STRINGi198804.BUsg199.

Structurei

3D structure databases

ProteinModelPortaliQ8K9T9.
SMRiQ8K9T9. Positions 59-888.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG2609.
KOiK00163.
OMAiEVIKVIW.
OrthoDBiEOG6BW4TW.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF00456. Transketolase_N. 2 hits.
[Graphical view]
PIRSFiPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00759. aceE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K9T9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEKLYNYDV DPVETNDWVQ SIESVIREEG LERAKFLIEK ILKKSKITRA
60 70 80 90 100
NFFKCFFTSD YINTISSEEE VEYPGDLILE KRIRSAIRWN AIMMVLRASK
110 120 130 140 150
KDLELGGHLS SFQSSATIYE VCFNHFFRSK NDEDGGDLVY FQGHIAPGIY
160 170 180 190 200
ARSFLEGRLS KKQIDNFRQE VDGKGLSSYP HPKLMPNFWQ FPTVSMGLGP
210 220 230 240 250
LCAIYQAKFL KYLQNRELKN TSKQTVYAFL GDGEMDEPES KGAISIAVRE
260 270 280 290 300
KLDNLIFVIN CNLQRLDGPV VGNGKIVNEL ESFFYGAGWK VIKVIWGGKW
310 320 330 340 350
DSLLKKDKTG KLIQLMNETI DGEYQTLKSK DGAYVRKYFF GKYQETLELV
360 370 380 390 400
KNMTDEEIWN LNRGGHDPKK MFNALKKAKE IKDKPTVILA HTVKGYGMGV
410 420 430 440 450
IAEGKNIAHQ IKKININGII YIRDRFNIPI SNEDIKELPY VVFEKNSKEY
460 470 480 490 500
CYMHQQRKKL GGYIPFRLSK FTNALNIPDL IDFKSLLKEQ NKKMSTTIAF
510 520 530 540 550
VRVLNLILKN HSIKNLIVPI IADEARTFGM EGLFRMIGIY SSIGQKYVPQ
560 570 580 590 600
DREQLAYYKE EKKGQILQEG INELGAASSW LAAATSYSTN DFPMIPFYIY
610 620 630 640 650
YSIFGFQRIG DLFWAAGDQQ ARGFLIGGTS GRTTLNGEGL QHEDGHSHIQ
660 670 680 690 700
SLTIPNCVSY DPAFAYEVAV IIQDGLRRMY GPLQENIYYY ITTINENYYM
710 720 730 740 750
PAMPQGVEKG ICKGIYKLKT FYATELKVQL MGSGAILRCI CKAGEILSND
760 770 780 790 800
YCITTDIYSV TSFTELARNG EDCERWNMLH PYEKKRIAYI KTVMNSSPAV
810 820 830 840 850
AATDYMKLFA EQIRHYIPSN EYHVLGTDGF GRSDSRDKLR DHFEVSAYYI
860 870 880
VVAALNLLAK LNNINKKVVE EAIIKFNINA DKINPRLA
Length:888
Mass (Da):101,458
Last modified:October 1, 2002 - v1
Checksum:iE127C03FB1261177
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67763.1.
RefSeqiNP_660552.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67763; AAM67763; BUsg_199.
GeneIDi1005396.
KEGGibas:BUsg199.
PATRICi21247185. VBIBucAph100086_0206.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67763.1.
RefSeqiNP_660552.1. NC_004061.1.

3D structure databases

ProteinModelPortaliQ8K9T9.
SMRiQ8K9T9. Positions 59-888.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198804.BUsg199.

Proteomic databases

PRIDEiQ8K9T9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM67763; AAM67763; BUsg_199.
GeneIDi1005396.
KEGGibas:BUsg199.
PATRICi21247185. VBIBucAph100086_0206.

Phylogenomic databases

eggNOGiCOG2609.
KOiK00163.
OMAiEVIKVIW.
OrthoDBiEOG6BW4TW.

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-209-MONOMER.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF00456. Transketolase_N. 2 hits.
[Graphical view]
PIRSFiPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00759. aceE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiODP1_BUCAP
AccessioniPrimary (citable) accession number: Q8K9T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: February 4, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.