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Q8K9T9

- ODP1_BUCAP

UniProt

Q8K9T9 - ODP1_BUCAP

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Protein
Pyruvate dehydrogenase E1 component
Gene
aceE, BUsg_199
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2 By similarity.

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-209-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component (EC:1.2.4.1)
Short name:
PDH E1 component
Gene namesi
Name:aceE
Ordered Locus Names:BUsg_199
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 888888Pyruvate dehydrogenase E1 component
PRO_0000162241Add
BLAST

Proteomic databases

PRIDEiQ8K9T9.

Interactioni

Subunit structurei

Homodimer By similarity. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Protein-protein interaction databases

STRINGi198804.BUsg199.

Structurei

3D structure databases

ProteinModelPortaliQ8K9T9.
SMRiQ8K9T9. Positions 59-888.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG2609.
KOiK00163.
OMAiKGIYKLD.
OrthoDBiEOG6BW4TW.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF00456. Transketolase_N. 2 hits.
[Graphical view]
PIRSFiPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00759. aceE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K9T9-1 [UniParc]FASTAAdd to Basket

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MSEKLYNYDV DPVETNDWVQ SIESVIREEG LERAKFLIEK ILKKSKITRA    50
NFFKCFFTSD YINTISSEEE VEYPGDLILE KRIRSAIRWN AIMMVLRASK 100
KDLELGGHLS SFQSSATIYE VCFNHFFRSK NDEDGGDLVY FQGHIAPGIY 150
ARSFLEGRLS KKQIDNFRQE VDGKGLSSYP HPKLMPNFWQ FPTVSMGLGP 200
LCAIYQAKFL KYLQNRELKN TSKQTVYAFL GDGEMDEPES KGAISIAVRE 250
KLDNLIFVIN CNLQRLDGPV VGNGKIVNEL ESFFYGAGWK VIKVIWGGKW 300
DSLLKKDKTG KLIQLMNETI DGEYQTLKSK DGAYVRKYFF GKYQETLELV 350
KNMTDEEIWN LNRGGHDPKK MFNALKKAKE IKDKPTVILA HTVKGYGMGV 400
IAEGKNIAHQ IKKININGII YIRDRFNIPI SNEDIKELPY VVFEKNSKEY 450
CYMHQQRKKL GGYIPFRLSK FTNALNIPDL IDFKSLLKEQ NKKMSTTIAF 500
VRVLNLILKN HSIKNLIVPI IADEARTFGM EGLFRMIGIY SSIGQKYVPQ 550
DREQLAYYKE EKKGQILQEG INELGAASSW LAAATSYSTN DFPMIPFYIY 600
YSIFGFQRIG DLFWAAGDQQ ARGFLIGGTS GRTTLNGEGL QHEDGHSHIQ 650
SLTIPNCVSY DPAFAYEVAV IIQDGLRRMY GPLQENIYYY ITTINENYYM 700
PAMPQGVEKG ICKGIYKLKT FYATELKVQL MGSGAILRCI CKAGEILSND 750
YCITTDIYSV TSFTELARNG EDCERWNMLH PYEKKRIAYI KTVMNSSPAV 800
AATDYMKLFA EQIRHYIPSN EYHVLGTDGF GRSDSRDKLR DHFEVSAYYI 850
VVAALNLLAK LNNINKKVVE EAIIKFNINA DKINPRLA 888
Length:888
Mass (Da):101,458
Last modified:October 1, 2002 - v1
Checksum:iE127C03FB1261177
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67763.1.
RefSeqiNP_660552.1. NC_004061.1.
WP_011053730.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67763; AAM67763; BUsg_199.
GeneIDi1005396.
KEGGibas:BUsg199.
PATRICi21247185. VBIBucAph100086_0206.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67763.1 .
RefSeqi NP_660552.1. NC_004061.1.
WP_011053730.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8K9T9.
SMRi Q8K9T9. Positions 59-888.
ModBasei Search...

Protein-protein interaction databases

STRINGi 198804.BUsg199.

Proteomic databases

PRIDEi Q8K9T9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67763 ; AAM67763 ; BUsg_199 .
GeneIDi 1005396.
KEGGi bas:BUsg199.
PATRICi 21247185. VBIBucAph100086_0206.

Phylogenomic databases

eggNOGi COG2609.
KOi K00163.
OMAi KGIYKLD.
OrthoDBi EOG6BW4TW.

Enzyme and pathway databases

BioCyci BAPH198804:GHMG-209-MONOMER.

Family and domain databases

Gene3Di 3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProi IPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view ]
Pfami PF00456. Transketolase_N. 2 hits.
[Graphical view ]
PIRSFi PIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMi SSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsi TIGR00759. aceE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiODP1_BUCAP
AccessioniPrimary (citable) accession number: Q8K9T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names

External Data

Dasty 3

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