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Q8K9T9 (ODP1_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component

Short name=PDH E1 component
EC=1.2.4.1
Gene names
Name:aceE
Ordered Locus Names:BUsg_199
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length888 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2 By similarity.

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactor

Thiamine pyrophosphate By similarity.

Subunit structure

Homodimer By similarity. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Ontologies

Keywords
   Biological processGlycolysis
   LigandPyruvate
Thiamine pyrophosphate
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionpyruvate dehydrogenase (acetyl-transferring) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 888888Pyruvate dehydrogenase E1 component
PRO_0000162241

Sequences

Sequence LengthMass (Da)Tools
Q8K9T9 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: E127C03FB1261177

FASTA888101,458
        10         20         30         40         50         60 
MSEKLYNYDV DPVETNDWVQ SIESVIREEG LERAKFLIEK ILKKSKITRA NFFKCFFTSD 

        70         80         90        100        110        120 
YINTISSEEE VEYPGDLILE KRIRSAIRWN AIMMVLRASK KDLELGGHLS SFQSSATIYE 

       130        140        150        160        170        180 
VCFNHFFRSK NDEDGGDLVY FQGHIAPGIY ARSFLEGRLS KKQIDNFRQE VDGKGLSSYP 

       190        200        210        220        230        240 
HPKLMPNFWQ FPTVSMGLGP LCAIYQAKFL KYLQNRELKN TSKQTVYAFL GDGEMDEPES 

       250        260        270        280        290        300 
KGAISIAVRE KLDNLIFVIN CNLQRLDGPV VGNGKIVNEL ESFFYGAGWK VIKVIWGGKW 

       310        320        330        340        350        360 
DSLLKKDKTG KLIQLMNETI DGEYQTLKSK DGAYVRKYFF GKYQETLELV KNMTDEEIWN 

       370        380        390        400        410        420 
LNRGGHDPKK MFNALKKAKE IKDKPTVILA HTVKGYGMGV IAEGKNIAHQ IKKININGII 

       430        440        450        460        470        480 
YIRDRFNIPI SNEDIKELPY VVFEKNSKEY CYMHQQRKKL GGYIPFRLSK FTNALNIPDL 

       490        500        510        520        530        540 
IDFKSLLKEQ NKKMSTTIAF VRVLNLILKN HSIKNLIVPI IADEARTFGM EGLFRMIGIY 

       550        560        570        580        590        600 
SSIGQKYVPQ DREQLAYYKE EKKGQILQEG INELGAASSW LAAATSYSTN DFPMIPFYIY 

       610        620        630        640        650        660 
YSIFGFQRIG DLFWAAGDQQ ARGFLIGGTS GRTTLNGEGL QHEDGHSHIQ SLTIPNCVSY 

       670        680        690        700        710        720 
DPAFAYEVAV IIQDGLRRMY GPLQENIYYY ITTINENYYM PAMPQGVEKG ICKGIYKLKT 

       730        740        750        760        770        780 
FYATELKVQL MGSGAILRCI CKAGEILSND YCITTDIYSV TSFTELARNG EDCERWNMLH 

       790        800        810        820        830        840 
PYEKKRIAYI KTVMNSSPAV AATDYMKLFA EQIRHYIPSN EYHVLGTDGF GRSDSRDKLR 

       850        860        870        880 
DHFEVSAYYI VVAALNLLAK LNNINKKVVE EAIIKFNINA DKINPRLA 

« Hide

References

[1]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE013218 Genomic DNA. Translation: AAM67763.1.
RefSeqNP_660552.1. NC_004061.1.

3D structure databases

ProteinModelPortalQ8K9T9.
SMRQ8K9T9. Positions 59-888.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198804.BUsg199.

Proteomic databases

PRIDEQ8K9T9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM67763; AAM67763; BUsg_199.
GeneID1005396.
KEGGbas:BUsg199.
PATRIC21247185. VBIBucAph100086_0206.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2609.
KOK00163.
OMAKGIYKLD.
OrthoDBEOG6BW4TW.

Enzyme and pathway databases

BioCycBAPH198804:GHMG-209-MONOMER.

Family and domain databases

Gene3D3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProIPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view]
PfamPF00456. Transketolase_N. 2 hits.
[Graphical view]
PIRSFPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsTIGR00759. aceE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODP1_BUCAP
AccessionPrimary (citable) accession number: Q8K9T9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: June 11, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names