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Q8K9T9

- ODP1_BUCAP

UniProt

Q8K9T9 - ODP1_BUCAP

Protein

Pyruvate dehydrogenase E1 component

Gene

aceE

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.By similarity

    Catalytic activityi

    Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Pyruvate, Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-209-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate dehydrogenase E1 component (EC:1.2.4.1)
    Short name:
    PDH E1 component
    Gene namesi
    Name:aceE
    Ordered Locus Names:BUsg_199
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 888888Pyruvate dehydrogenase E1 componentPRO_0000162241Add
    BLAST

    Proteomic databases

    PRIDEiQ8K9T9.

    Interactioni

    Subunit structurei

    Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).By similarity

    Protein-protein interaction databases

    STRINGi198804.BUsg199.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K9T9.
    SMRiQ8K9T9. Positions 59-888.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG2609.
    KOiK00163.
    OMAiKGIYKLD.
    OrthoDBiEOG6BW4TW.

    Family and domain databases

    Gene3Di3.40.50.920. 1 hit.
    3.40.50.970. 2 hits.
    InterProiIPR004660. 2-oxoA_DH_E1.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005474. Transketolase_N.
    [Graphical view]
    PfamiPF00456. Transketolase_N. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000156. Pyruvate_dh_E1. 1 hit.
    SUPFAMiSSF52518. SSF52518. 2 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsiTIGR00759. aceE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8K9T9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEKLYNYDV DPVETNDWVQ SIESVIREEG LERAKFLIEK ILKKSKITRA    50
    NFFKCFFTSD YINTISSEEE VEYPGDLILE KRIRSAIRWN AIMMVLRASK 100
    KDLELGGHLS SFQSSATIYE VCFNHFFRSK NDEDGGDLVY FQGHIAPGIY 150
    ARSFLEGRLS KKQIDNFRQE VDGKGLSSYP HPKLMPNFWQ FPTVSMGLGP 200
    LCAIYQAKFL KYLQNRELKN TSKQTVYAFL GDGEMDEPES KGAISIAVRE 250
    KLDNLIFVIN CNLQRLDGPV VGNGKIVNEL ESFFYGAGWK VIKVIWGGKW 300
    DSLLKKDKTG KLIQLMNETI DGEYQTLKSK DGAYVRKYFF GKYQETLELV 350
    KNMTDEEIWN LNRGGHDPKK MFNALKKAKE IKDKPTVILA HTVKGYGMGV 400
    IAEGKNIAHQ IKKININGII YIRDRFNIPI SNEDIKELPY VVFEKNSKEY 450
    CYMHQQRKKL GGYIPFRLSK FTNALNIPDL IDFKSLLKEQ NKKMSTTIAF 500
    VRVLNLILKN HSIKNLIVPI IADEARTFGM EGLFRMIGIY SSIGQKYVPQ 550
    DREQLAYYKE EKKGQILQEG INELGAASSW LAAATSYSTN DFPMIPFYIY 600
    YSIFGFQRIG DLFWAAGDQQ ARGFLIGGTS GRTTLNGEGL QHEDGHSHIQ 650
    SLTIPNCVSY DPAFAYEVAV IIQDGLRRMY GPLQENIYYY ITTINENYYM 700
    PAMPQGVEKG ICKGIYKLKT FYATELKVQL MGSGAILRCI CKAGEILSND 750
    YCITTDIYSV TSFTELARNG EDCERWNMLH PYEKKRIAYI KTVMNSSPAV 800
    AATDYMKLFA EQIRHYIPSN EYHVLGTDGF GRSDSRDKLR DHFEVSAYYI 850
    VVAALNLLAK LNNINKKVVE EAIIKFNINA DKINPRLA 888
    Length:888
    Mass (Da):101,458
    Last modified:October 1, 2002 - v1
    Checksum:iE127C03FB1261177
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67763.1.
    RefSeqiNP_660552.1. NC_004061.1.
    WP_011053730.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67763; AAM67763; BUsg_199.
    GeneIDi1005396.
    KEGGibas:BUsg199.
    PATRICi21247185. VBIBucAph100086_0206.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67763.1 .
    RefSeqi NP_660552.1. NC_004061.1.
    WP_011053730.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8K9T9.
    SMRi Q8K9T9. Positions 59-888.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg199.

    Proteomic databases

    PRIDEi Q8K9T9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67763 ; AAM67763 ; BUsg_199 .
    GeneIDi 1005396.
    KEGGi bas:BUsg199.
    PATRICi 21247185. VBIBucAph100086_0206.

    Phylogenomic databases

    eggNOGi COG2609.
    KOi K00163.
    OMAi KGIYKLD.
    OrthoDBi EOG6BW4TW.

    Enzyme and pathway databases

    BioCyci BAPH198804:GHMG-209-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.920. 1 hit.
    3.40.50.970. 2 hits.
    InterProi IPR004660. 2-oxoA_DH_E1.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005474. Transketolase_N.
    [Graphical view ]
    Pfami PF00456. Transketolase_N. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000156. Pyruvate_dh_E1. 1 hit.
    SUPFAMi SSF52518. SSF52518. 2 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsi TIGR00759. aceE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiODP1_BUCAP
    AccessioniPrimary (citable) accession number: Q8K9T9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names

    External Data

    Dasty 3