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Q8K9T7

- DLDH_BUCAP

UniProt

Q8K9T7 - DLDH_BUCAP

Protein

Dihydrolipoyl dehydrogenase

Gene

lpdA

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes.By similarity

    Catalytic activityi

    Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH.

    Cofactori

    Binds 1 FAD per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei54 – 541FADBy similarity
    Binding sitei117 – 1171FAD; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei205 – 2051NADBy similarity
    Binding sitei238 – 2381NAD; via amide nitrogenBy similarity
    Binding sitei314 – 3141FADBy similarity
    Binding sitei322 – 3221FAD; via amide nitrogenBy similarity
    Active sitei446 – 4461Proton acceptorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi36 – 4510FADBy similarity
    Nucleotide bindingi182 – 1865NADBy similarity
    Nucleotide bindingi271 – 2744NADBy similarity

    GO - Molecular functioni

    1. dihydrolipoyl dehydrogenase activity Source: UniProtKB-EC
    2. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro
    2. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-211-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydrolipoyl dehydrogenase (EC:1.8.1.4)
    Alternative name(s):
    Dihydrolipoamide dehydrogenase
    E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes
    Gene namesi
    Name:lpdA
    Ordered Locus Names:BUsg_201
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 476476Dihydrolipoyl dehydrogenasePRO_0000068020Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi45 ↔ 50Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi198804.BUsg201.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K9T7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG1249.
    KOiK00382.
    OMAiIWNSTDA.
    OrthoDBiEOG6QCD6D.

    Family and domain databases

    Gene3Di3.30.390.30. 1 hit.
    InterProiIPR016156. FAD/NAD-linked_Rdtase_dimer.
    IPR013027. FAD_pyr_nucl-diS_OxRdtase.
    IPR006258. Lipoamide_DH.
    IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    IPR012999. Pyr_OxRdtase_I_AS.
    IPR001327. Pyr_OxRdtase_NAD-bd_dom.
    [Graphical view]
    PfamiPF00070. Pyr_redox. 1 hit.
    PF07992. Pyr_redox_2. 1 hit.
    PF02852. Pyr_redox_dim. 1 hit.
    [Graphical view]
    PRINTSiPR00368. FADPNR.
    SUPFAMiSSF55424. SSF55424. 1 hit.
    TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
    PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K9T7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHQEIQSEVV IIGSGPAGYS AAFRCADLGL ETVLIEHQER LGGVCLNVGC    50
    IPSKSLLHIA KIIKDASELS ESGVFFNKPI IDIKKINNWK EKIIKKLTTG 100
    LSNMGEKRKV RIVQGKALFN TDHSVLVKNK KNDFTIFFKH AIIATGSKPI 150
    KIPSLPNEDN RIWNSTDALS LKSIPNRFLI IGGGIIGLEM ATIYSALGSK 200
    VDIVDRFNAF LPSVDKDITD IYIKSIKKRF KLLLNTHVKS VEKSKDNDLI 250
    VKIAEENSDE NVCCYDNILV AIGRSPNVDF LGLEKIGLKL NESGFIEINQ 300
    QLKTNISHIY AIGDVTGFPM LAHKAVQQAH IAAEVISGKK HYFEPKVIPS 350
    VAYTDPEIAW VGLSEKEAEN NDIDYEVSLF PWSASGRAHA SNCTLGMTKL 400
    IFNKNTNKII GGSIIGTNAS ELISEIGLAI EMGSDAEDIS LTIHPHPTLS 450
    ESISLASEVF QGTITDLLNL KKSLLN 476
    Length:476
    Mass (Da):52,187
    Last modified:October 1, 2002 - v1
    Checksum:i2BCD5F1ECB08BA58
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67765.1.
    RefSeqiNP_660554.1. NC_004061.1.
    WP_011053732.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67765; AAM67765; BUsg_201.
    GeneIDi1005398.
    KEGGibas:BUsg201.
    PATRICi21247189. VBIBucAph100086_0208.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67765.1 .
    RefSeqi NP_660554.1. NC_004061.1.
    WP_011053732.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8K9T7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg201.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67765 ; AAM67765 ; BUsg_201 .
    GeneIDi 1005398.
    KEGGi bas:BUsg201.
    PATRICi 21247189. VBIBucAph100086_0208.

    Phylogenomic databases

    eggNOGi COG1249.
    KOi K00382.
    OMAi IWNSTDA.
    OrthoDBi EOG6QCD6D.

    Enzyme and pathway databases

    BioCyci BAPH198804:GHMG-211-MONOMER.

    Family and domain databases

    Gene3Di 3.30.390.30. 1 hit.
    InterProi IPR016156. FAD/NAD-linked_Rdtase_dimer.
    IPR013027. FAD_pyr_nucl-diS_OxRdtase.
    IPR006258. Lipoamide_DH.
    IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    IPR012999. Pyr_OxRdtase_I_AS.
    IPR001327. Pyr_OxRdtase_NAD-bd_dom.
    [Graphical view ]
    Pfami PF00070. Pyr_redox. 1 hit.
    PF07992. Pyr_redox_2. 1 hit.
    PF02852. Pyr_redox_dim. 1 hit.
    [Graphical view ]
    PRINTSi PR00368. FADPNR.
    SUPFAMi SSF55424. SSF55424. 1 hit.
    TIGRFAMsi TIGR01350. lipoamide_DH. 1 hit.
    PROSITEi PS00076. PYRIDINE_REDOX_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiDLDH_BUCAP
    AccessioniPrimary (citable) accession number: Q8K9T7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The active site is a redox-active disulfide bond.By similarity

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3