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Q8K9T4

- MURG_BUCAP

UniProt

Q8K9T4 - MURG_BUCAP

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Protein
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
Gene
murG, BUsg_210
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity.UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
  3. undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. UDP-N-acetylgalactosamine biosynthetic process Source: InterPro
  2. cell cycle Source: UniProtKB-KW
  3. cell division Source: UniProtKB-KW
  4. lipid glycosylation Source: UniProtKB-HAMAP
  5. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  6. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-220-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC:2.4.1.227)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Gene namesi
Name:murG
Ordered Locus Names:BUsg_210
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation
PRO_0000109154Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg210.

Structurei

3D structure databases

ProteinModelPortaliQ8K9T4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0707.
KOiK02563.
OMAiPFIKDMA.
OrthoDBiEOG61VZFD.

Family and domain databases

HAMAPiMF_00033. MurG.
InterProiIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01133. murG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K9T4-1 [UniParc]FASTAAdd to Basket

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MNSKRIIILA GGSGGHVFPG LTIAKHLIKK GWDINWIGTK NKIESEIIPK    50
CNIKIHFIKI QGLRNSSLKN LIMTPINVLN SYLQVRKIIK NWIPDIILGM 100
GGYVSGPGGL AAWSCKIPFI LHEQNKIAGI TNKLLSKIST KNMQAFSGTL 150
LNAEIVGNPI RKNIIDIPPP IKRFKNRKGP LRILIIGGSQ GASIFNKILP 200
KISFFLQEKA IIWHQSGNND LQKTRKKYKK YSTYKHIVSS FIKNIAEAYE 250
WADIIISRSG ALTVSEITVV GLGAIFIPYP HKDKQQYLNA EDLENNGAAK 300
IIEQSMFTAE LIIKILNSLN REKLFIMAKK AYSLGIRNST SKISKIIHDV 350
SNKI 354
Length:354
Mass (Da):39,559
Last modified:October 1, 2002 - v1
Checksum:i848B5F42605F2852
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67773.1.
RefSeqiNP_660562.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67773; AAM67773; BUsg_210.
GeneIDi1005409.
KEGGibas:BUsg210.
PATRICi21247209. VBIBucAph100086_0218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67773.1 .
RefSeqi NP_660562.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8K9T4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg210.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67773 ; AAM67773 ; BUsg_210 .
GeneIDi 1005409.
KEGGi bas:BUsg210.
PATRICi 21247209. VBIBucAph100086_0218.

Phylogenomic databases

eggNOGi COG0707.
KOi K02563.
OMAi PFIKDMA.
OrthoDBi EOG61VZFD.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci BAPH198804:GHMG-220-MONOMER.

Family and domain databases

HAMAPi MF_00033. MurG.
InterProi IPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view ]
Pfami PF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01133. murG. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiMURG_BUCAP
AccessioniPrimary (citable) accession number: Q8K9T4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: June 11, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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