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Q8K9R9

- GMHA_BUCAP

UniProt

Q8K9R9 - GMHA_BUCAP

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Protein

Phosphoheptose isomerase

Gene
gmhA, lpcA, BUsg_241
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate By similarity.UniRule annotation

Catalytic activityi

D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Zinc By similarity
Metal bindingi65 – 651Zinc By similarity
Binding sitei65 – 651Substrate By similarity
Binding sitei124 – 1241Substrate By similarity
Metal bindingi172 – 1721Zinc By similarity
Binding sitei172 – 1721Substrate By similarity
Metal bindingi180 – 1801Zinc By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. D-sedoheptulose 7-phosphate isomerase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-glycero-D-manno-heptose 7-phosphate biosynthetic process Source: UniProtKB-UniPathway
  2. lipopolysaccharide core region biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-255-MONOMER.
UniPathwayiUPA00041; UER00436.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoheptose isomerase (EC:5.3.1.28)
Alternative name(s):
Sedoheptulose 7-phosphate isomerase
Gene namesi
Name:gmhA
Synonyms:lpcA
Ordered Locus Names:BUsg_241
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194Phosphoheptose isomeraseUniRule annotationPRO_0000136519Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi198804.BUsg241.

Structurei

3D structure databases

ProteinModelPortaliQ8K9R9.
SMRiQ8K9R9. Positions 1-192.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 194158SISAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni52 – 543Substrate binding By similarity
Regioni93 – 942Substrate binding By similarity
Regioni119 – 1213Substrate binding By similarity

Sequence similaritiesi

Belongs to the SIS family. GmhA subfamily.
Contains 1 SIS domain.

Phylogenomic databases

eggNOGiCOG0279.
KOiK03271.
OMAiHVFSRYV.
OrthoDBiEOG6384PC.

Family and domain databases

HAMAPiMF_00067. GmhA.
InterProiIPR004515. Phosphoheptose_Isoase.
IPR001347. SIS.
[Graphical view]
PfamiPF13580. SIS_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00441. gmhA. 1 hit.
PROSITEiPS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K9R9-1 [UniParc]FASTAAdd to Basket

« Hide

MYKKIISSEL DAALKILKNF LKNEEQIENI EKAAILIAKS FKNKNKVISC    50
GNGGSHCDAV HFSEELTGLY REKRPGYAAI PISDVGHISA IGNDFGYDQI 100
FSRYIESIGL PNDVLLAIST SGNSINIINA IQTAHRKKMK VIVLTGNDGG 150
QVKHLSDVEI CIPYHGYSDR IQEMHIKIIH ILILIIEKEM KKIN 194
Length:194
Mass (Da):21,631
Last modified:October 1, 2002 - v1
Checksum:i803DA6B727B36B30
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67800.1.
RefSeqiNP_660589.1. NC_004061.1.
WP_011053767.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67800; AAM67800; BUsg_241.
GeneIDi1005442.
KEGGibas:BUsg241.
PATRICi21247285. VBIBucAph100086_0252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67800.1 .
RefSeqi NP_660589.1. NC_004061.1.
WP_011053767.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8K9R9.
SMRi Q8K9R9. Positions 1-192.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg241.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67800 ; AAM67800 ; BUsg_241 .
GeneIDi 1005442.
KEGGi bas:BUsg241.
PATRICi 21247285. VBIBucAph100086_0252.

Phylogenomic databases

eggNOGi COG0279.
KOi K03271.
OMAi HVFSRYV.
OrthoDBi EOG6384PC.

Enzyme and pathway databases

UniPathwayi UPA00041 ; UER00436 .
BioCyci BAPH198804:GHMG-255-MONOMER.

Family and domain databases

HAMAPi MF_00067. GmhA.
InterProi IPR004515. Phosphoheptose_Isoase.
IPR001347. SIS.
[Graphical view ]
Pfami PF13580. SIS_2. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00441. gmhA. 1 hit.
PROSITEi PS51464. SIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiGMHA_BUCAP
AccessioniPrimary (citable) accession number: Q8K9R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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