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Protein

Protein GrpE 1

Gene

grpE1

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response

Enzyme and pathway databases

BioCyciBAPH198804:G1FZU-261-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GrpE 1UniRule annotation
Alternative name(s):
HSP-70 cofactor 1UniRule annotation
Gene namesi
Name:grpE1UniRule annotation
Ordered Locus Names:BUsg_243
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000416 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001137581 – 202Protein GrpE 1Add BLAST202

Interactioni

Subunit structurei

Homodimer.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi198804.BUsg243

Structurei

3D structure databases

ProteinModelPortaliQ8K9R7
SMRiQ8K9R7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105K90 Bacteria
COG0576 LUCA
KOiK03687
OMAiNDESHFI
OrthoDBiPOG091H00J8

Family and domain databases

CDDicd00446 GrpE, 1 hit
Gene3Di2.30.22.10, 1 hit
3.90.20.20, 1 hit
HAMAPiMF_01151 GrpE, 1 hit
InterProiView protein in InterPro
IPR000740 GrpE
IPR013805 GrpE_coiled_coil
IPR009012 GrpE_head
PANTHERiPTHR21237 PTHR21237, 1 hit
PfamiView protein in Pfam
PF01025 GrpE, 1 hit
SUPFAMiSSF51064 SSF51064, 1 hit
SSF58014 SSF58014, 1 hit
PROSITEiView protein in PROSITE
PS01071 GRPE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K9R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNKKEEKIN NLKKEEKINN LKKEEKINNL KKEEKEKNDD VQNKIIDLLE
60 70 80 90 100
IKLKKSQEKI INMQLKNHEE ILKLNYRLNS DIEKSRKFSL EKVIIEFLPI
110 120 130 140 150
IDNIERALSV IKDKKEAFYL EIINKMNFIF SLLEEILSEF NVSKINEKNI
160 170 180 190 200
SFDPEIHQAM SINYNDEIED NHVVDVMQSG YMLHKARLLR PAMVIVSKRK

NN
Length:202
Mass (Da):24,068
Last modified:October 1, 2002 - v1
Checksum:i67C384A008834596
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA Translation: AAM67802.1
RefSeqiWP_011053769.1, NC_004061.1

Genome annotation databases

EnsemblBacteriaiAAM67802; AAM67802; BUsg_243
KEGGibas:BUsg_243

Entry informationi

Entry nameiGRPE1_BUCAP
AccessioniPrimary (citable) accession number: Q8K9R7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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