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Q8K9R7

- GRPE1_BUCAP

UniProt

Q8K9R7 - GRPE1_BUCAP

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Protein
Protein GrpE 1
Gene
grpE1, BUsg_243
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding By similarity.UniRule annotation

GO - Molecular functioni

  1. adenyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processi

  1. protein folding Source: InterPro
  2. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-257-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GrpE 1
Alternative name(s):
HSP-70 cofactor 1
Gene namesi
Name:grpE1
Ordered Locus Names:BUsg_243
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202Protein GrpE 1UniRule annotation
PRO_0000113758Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi198804.BUsg243.

Structurei

3D structure databases

ProteinModelPortaliQ8K9R7.

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.

Phylogenomic databases

eggNOGiCOG0576.
KOiK03687.
OMAiHELHEAI.
OrthoDBiEOG6B09TZ.

Family and domain databases

Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K9R7-1 [UniParc]FASTAAdd to Basket

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MKNKKEEKIN NLKKEEKINN LKKEEKINNL KKEEKEKNDD VQNKIIDLLE    50
IKLKKSQEKI INMQLKNHEE ILKLNYRLNS DIEKSRKFSL EKVIIEFLPI 100
IDNIERALSV IKDKKEAFYL EIINKMNFIF SLLEEILSEF NVSKINEKNI 150
SFDPEIHQAM SINYNDEIED NHVVDVMQSG YMLHKARLLR PAMVIVSKRK 200
NN 202
Length:202
Mass (Da):24,068
Last modified:October 1, 2002 - v1
Checksum:i67C384A008834596
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67802.1.
RefSeqiNP_660591.1. NC_004061.1.
WP_011053769.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67802; AAM67802; BUsg_243.
GeneIDi1005444.
KEGGibas:BUsg243.
PATRICi21247289. VBIBucAph100086_0254.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67802.1 .
RefSeqi NP_660591.1. NC_004061.1.
WP_011053769.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8K9R7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg243.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67802 ; AAM67802 ; BUsg_243 .
GeneIDi 1005444.
KEGGi bas:BUsg243.
PATRICi 21247289. VBIBucAph100086_0254.

Phylogenomic databases

eggNOGi COG0576.
KOi K03687.
OMAi HELHEAI.
OrthoDBi EOG6B09TZ.

Enzyme and pathway databases

BioCyci BAPH198804:GHMG-257-MONOMER.

Family and domain databases

Gene3Di 2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPi MF_01151. GrpE.
InterProi IPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view ]
PANTHERi PTHR21237. PTHR21237. 1 hit.
Pfami PF01025. GrpE. 1 hit.
[Graphical view ]
SUPFAMi SSF51064. SSF51064. 1 hit.
PROSITEi PS01071. GRPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiGRPE1_BUCAP
AccessioniPrimary (citable) accession number: Q8K9R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3