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Q8K9R7

- GRPE1_BUCAP

UniProt

Q8K9R7 - GRPE1_BUCAP

Protein

Protein GrpE 1

Gene

grpE1

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.UniRule annotation

    GO - Molecular functioni

    1. adenyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. protein folding Source: InterPro
    2. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-257-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein GrpE 1UniRule annotation
    Alternative name(s):
    HSP-70 cofactor 1UniRule annotation
    Gene namesi
    Name:grpE1UniRule annotation
    Ordered Locus Names:BUsg_243
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 202202Protein GrpE 1PRO_0000113758Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi198804.BUsg243.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K9R7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GrpE family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0576.
    KOiK03687.
    OMAiHELHEAI.
    OrthoDBiEOG6B09TZ.

    Family and domain databases

    Gene3Di2.30.22.10. 1 hit.
    3.90.20.20. 1 hit.
    HAMAPiMF_01151. GrpE.
    InterProiIPR000740. GrpE.
    IPR013805. GrpE_coiled_coil.
    IPR009012. GrpE_head.
    [Graphical view]
    PANTHERiPTHR21237. PTHR21237. 1 hit.
    PfamiPF01025. GrpE. 1 hit.
    [Graphical view]
    SUPFAMiSSF51064. SSF51064. 1 hit.
    PROSITEiPS01071. GRPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K9R7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNKKEEKIN NLKKEEKINN LKKEEKINNL KKEEKEKNDD VQNKIIDLLE    50
    IKLKKSQEKI INMQLKNHEE ILKLNYRLNS DIEKSRKFSL EKVIIEFLPI 100
    IDNIERALSV IKDKKEAFYL EIINKMNFIF SLLEEILSEF NVSKINEKNI 150
    SFDPEIHQAM SINYNDEIED NHVVDVMQSG YMLHKARLLR PAMVIVSKRK 200
    NN 202
    Length:202
    Mass (Da):24,068
    Last modified:October 1, 2002 - v1
    Checksum:i67C384A008834596
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67802.1.
    RefSeqiNP_660591.1. NC_004061.1.
    WP_011053769.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67802; AAM67802; BUsg_243.
    GeneIDi1005444.
    KEGGibas:BUsg243.
    PATRICi21247289. VBIBucAph100086_0254.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67802.1 .
    RefSeqi NP_660591.1. NC_004061.1.
    WP_011053769.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8K9R7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg243.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67802 ; AAM67802 ; BUsg_243 .
    GeneIDi 1005444.
    KEGGi bas:BUsg243.
    PATRICi 21247289. VBIBucAph100086_0254.

    Phylogenomic databases

    eggNOGi COG0576.
    KOi K03687.
    OMAi HELHEAI.
    OrthoDBi EOG6B09TZ.

    Enzyme and pathway databases

    BioCyci BAPH198804:GHMG-257-MONOMER.

    Family and domain databases

    Gene3Di 2.30.22.10. 1 hit.
    3.90.20.20. 1 hit.
    HAMAPi MF_01151. GrpE.
    InterProi IPR000740. GrpE.
    IPR013805. GrpE_coiled_coil.
    IPR009012. GrpE_head.
    [Graphical view ]
    PANTHERi PTHR21237. PTHR21237. 1 hit.
    Pfami PF01025. GrpE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51064. SSF51064. 1 hit.
    PROSITEi PS01071. GRPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiGRPE1_BUCAP
    AccessioniPrimary (citable) accession number: Q8K9R7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3