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Q8K9R4

- TADA_BUCAP

UniProt

Q8K9R4 - TADA_BUCAP

Protein

tRNA-specific adenosine deaminase

Gene

tadA

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).UniRule annotation

    Catalytic activityi

    Adenine(34) in tRNA + H2O = hypoxanthine(34) in tRNA + NH3.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi55 – 551Zinc; via pros nitrogen; catalyticUniRule annotation
    Active sitei57 – 571Proton donorUniRule annotation
    Metal bindingi85 – 851Zinc; catalyticUniRule annotation
    Metal bindingi88 – 881Zinc; catalyticUniRule annotation

    GO - Molecular functioni

    1. tRNA-specific adenosine-34 deaminase activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tRNA wobble adenosine to inosine editing Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-260-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA-specific adenosine deaminaseUniRule annotation (EC:3.5.4.33UniRule annotation)
    Gene namesi
    Name:tadAUniRule annotation
    Ordered Locus Names:BUsg_246
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 151151tRNA-specific adenosine deaminasePRO_0000171730Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi198804.BUsg246.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K9R4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 10399CMP/dCMP deaminase zinc-bindingUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cytidine and deoxycytidylate deaminase family.UniRule annotation
    Contains 1 CMP/dCMP deaminase zinc-binding domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0590.
    KOiK11991.
    OMAiAVVFDSN.
    OrthoDBiEOG64FKGZ.

    Family and domain databases

    HAMAPiMF_00972. tRNA_aden_deaminase.
    InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR016193. Cytidine_deaminase-like.
    IPR028883. tRNA_aden_deaminase.
    [Graphical view]
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53927. SSF53927. 1 hit.
    PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K9R4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSNRDSYWM KIALKYAYYA EENGEVPIGA ILVFQEKIIG TGWNSVISQN    50
    DSTAHAEIIA LREAGRNIKN YRLVNTTLYV TLQPCMMCCG AIINSRIKRL 100
    VFGASYKDLK KNPFLKKIFI NLEKNKLKIK KHIMRNECAK ILSNFFKNKR 150
    F 151
    Length:151
    Mass (Da):17,502
    Last modified:October 1, 2002 - v1
    Checksum:i8B3F699B11203951
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67805.1.
    RefSeqiNP_660594.1. NC_004061.1.
    WP_011053772.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67805; AAM67805; BUsg_246.
    GeneIDi1005448.
    KEGGibas:BUsg246.
    PATRICi21247295. VBIBucAph100086_0257.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67805.1 .
    RefSeqi NP_660594.1. NC_004061.1.
    WP_011053772.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8K9R4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg246.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67805 ; AAM67805 ; BUsg_246 .
    GeneIDi 1005448.
    KEGGi bas:BUsg246.
    PATRICi 21247295. VBIBucAph100086_0257.

    Phylogenomic databases

    eggNOGi COG0590.
    KOi K11991.
    OMAi AVVFDSN.
    OrthoDBi EOG64FKGZ.

    Enzyme and pathway databases

    BioCyci BAPH198804:GHMG-260-MONOMER.

    Family and domain databases

    HAMAPi MF_00972. tRNA_aden_deaminase.
    InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR016193. Cytidine_deaminase-like.
    IPR028883. tRNA_aden_deaminase.
    [Graphical view ]
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53927. SSF53927. 1 hit.
    PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiTADA_BUCAP
    AccessioniPrimary (citable) accession number: Q8K9R4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3