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Q8K9R0

- LEP_BUCAP

UniProt

Q8K9R0 - LEP_BUCAP

Protein

Signal peptidase I

Gene

lepB

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei88 – 881By similarity
    Active sitei142 – 1421By similarity

    GO - Molecular functioni

    1. serine-type peptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-264-MONOMER.

    Protein family/group databases

    MEROPSiS26.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal peptidase I (EC:3.4.21.89)
    Short name:
    SPase I
    Alternative name(s):
    Leader peptidase I
    Gene namesi
    Name:lepB
    Ordered Locus Names:BUsg_250
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Signal peptidase IPRO_0000109504Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi198804.BUsg250.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K9R0.
    SMRiQ8K9R0. Positions 75-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 6336CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini85 – 312228ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei64 – 8421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S26 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0681.
    KOiK03100.
    OMAiFKYPKDP.
    OrthoDBiEOG6KDKTM.

    Family and domain databases

    Gene3Di2.10.109.10. 2 hits.
    2.170.230.10. 1 hit.
    InterProiIPR000223. Pept_S26A_signal_pept_1.
    IPR019758. Pept_S26A_signal_pept_1_CS.
    IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
    IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
    IPR028360. Peptidase_S24/S26_b-rbn.
    IPR019759. Peptidase_S24_S26.
    IPR015927. Peptidase_S24_S26A/B/C.
    IPR019533. Peptidase_S26.
    IPR019766. Peptidase_S26A_all-beta_subdom.
    [Graphical view]
    PANTHERiPTHR12383. PTHR12383. 1 hit.
    PfamiPF00717. Peptidase_S24. 1 hit.
    PF10502. Peptidase_S26. 1 hit.
    [Graphical view]
    PRINTSiPR00727. LEADERPTASE.
    SUPFAMiSSF51306. SSF51306. 1 hit.
    TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.
    PROSITEiPS00501. SPASE_I_1. 1 hit.
    PS00760. SPASE_I_2. 1 hit.
    PS00761. SPASE_I_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K9R0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRNILTIFLL TSTFFTGILW IIDHILLIKN YFYNKKKTKN NNTILINKVI    50
    LENKKCFFRS LSSLFPTFFI VFIIRSFIYE PFQIPSGSMM PTLLIGDFIL 100
    VKKFSYGIKE PITNKTIIKM NLPQRGDIVV FKHPKNNIDY IKRVVGLPGD 150
    KIQYDINRKK IKICINYTNQ KNCENKLFIT YSKPKLSNFF QKIYLLKSRT 200
    NEEEKVYNSI YFKKVEEKIN NLKHNILILD GINSKINDYY QQKGMPKLIW 250
    IVPKNKYFMM GDNRDNSLDS RYWGFVPEEN LLGKATKIWM SFEKKENEWP 300
    TGIRIKRIGN IY 312
    Length:312
    Mass (Da):37,103
    Last modified:October 1, 2002 - v1
    Checksum:i63602053A16A0D8B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67809.1.
    RefSeqiNP_660598.1. NC_004061.1.
    WP_011053776.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67809; AAM67809; BUsg_250.
    GeneIDi1005452.
    KEGGibas:BUsg250.
    PATRICi21247303. VBIBucAph100086_0261.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67809.1 .
    RefSeqi NP_660598.1. NC_004061.1.
    WP_011053776.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8K9R0.
    SMRi Q8K9R0. Positions 75-311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg250.

    Protein family/group databases

    MEROPSi S26.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67809 ; AAM67809 ; BUsg_250 .
    GeneIDi 1005452.
    KEGGi bas:BUsg250.
    PATRICi 21247303. VBIBucAph100086_0261.

    Phylogenomic databases

    eggNOGi COG0681.
    KOi K03100.
    OMAi FKYPKDP.
    OrthoDBi EOG6KDKTM.

    Enzyme and pathway databases

    BioCyci BAPH198804:GHMG-264-MONOMER.

    Family and domain databases

    Gene3Di 2.10.109.10. 2 hits.
    2.170.230.10. 1 hit.
    InterProi IPR000223. Pept_S26A_signal_pept_1.
    IPR019758. Pept_S26A_signal_pept_1_CS.
    IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
    IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
    IPR028360. Peptidase_S24/S26_b-rbn.
    IPR019759. Peptidase_S24_S26.
    IPR015927. Peptidase_S24_S26A/B/C.
    IPR019533. Peptidase_S26.
    IPR019766. Peptidase_S26A_all-beta_subdom.
    [Graphical view ]
    PANTHERi PTHR12383. PTHR12383. 1 hit.
    Pfami PF00717. Peptidase_S24. 1 hit.
    PF10502. Peptidase_S26. 1 hit.
    [Graphical view ]
    PRINTSi PR00727. LEADERPTASE.
    SUPFAMi SSF51306. SSF51306. 1 hit.
    TIGRFAMsi TIGR02227. sigpep_I_bact. 1 hit.
    PROSITEi PS00501. SPASE_I_1. 1 hit.
    PS00760. SPASE_I_2. 1 hit.
    PS00761. SPASE_I_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiLEP_BUCAP
    AccessioniPrimary (citable) accession number: Q8K9R0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3