SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8K9R0

- LEP_BUCAP

UniProt

Q8K9R0 - LEP_BUCAP

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Signal peptidase I

Gene
lepB, BUsg_250
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881 By similarity
Active sitei142 – 1421 By similarity

GO - Molecular functioni

  1. serine-type peptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-264-MONOMER.

Protein family/group databases

MEROPSiS26.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase I (EC:3.4.21.89)
Short name:
SPase I
Alternative name(s):
Leader peptidase I
Gene namesi
Name:lepB
Ordered Locus Names:BUsg_250
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Reviewed predictionAdd
BLAST
Topological domaini28 – 6336Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei64 – 8421Helical; Reviewed predictionAdd
BLAST
Topological domaini85 – 312228Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Signal peptidase IPRO_0000109504Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg250.

Structurei

3D structure databases

ProteinModelPortaliQ8K9R0.
SMRiQ8K9R0. Positions 75-311.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0681.
KOiK03100.
OMAiFKYPKDP.
OrthoDBiEOG6KDKTM.

Family and domain databases

Gene3Di2.10.109.10. 2 hits.
2.170.230.10. 1 hit.
InterProiIPR000223. Pept_S26A_signal_pept_1.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR019533. Peptidase_S26.
IPR019766. Peptidase_S26A_all-beta_subdom.
[Graphical view]
PANTHERiPTHR12383. PTHR12383. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
PF10502. Peptidase_S26. 1 hit.
[Graphical view]
PRINTSiPR00727. LEADERPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00760. SPASE_I_2. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K9R0-1 [UniParc]FASTAAdd to Basket

« Hide

MRNILTIFLL TSTFFTGILW IIDHILLIKN YFYNKKKTKN NNTILINKVI    50
LENKKCFFRS LSSLFPTFFI VFIIRSFIYE PFQIPSGSMM PTLLIGDFIL 100
VKKFSYGIKE PITNKTIIKM NLPQRGDIVV FKHPKNNIDY IKRVVGLPGD 150
KIQYDINRKK IKICINYTNQ KNCENKLFIT YSKPKLSNFF QKIYLLKSRT 200
NEEEKVYNSI YFKKVEEKIN NLKHNILILD GINSKINDYY QQKGMPKLIW 250
IVPKNKYFMM GDNRDNSLDS RYWGFVPEEN LLGKATKIWM SFEKKENEWP 300
TGIRIKRIGN IY 312
Length:312
Mass (Da):37,103
Last modified:October 1, 2002 - v1
Checksum:i63602053A16A0D8B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67809.1.
RefSeqiNP_660598.1. NC_004061.1.
WP_011053776.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67809; AAM67809; BUsg_250.
GeneIDi1005452.
KEGGibas:BUsg250.
PATRICi21247303. VBIBucAph100086_0261.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67809.1 .
RefSeqi NP_660598.1. NC_004061.1.
WP_011053776.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8K9R0.
SMRi Q8K9R0. Positions 75-311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg250.

Protein family/group databases

MEROPSi S26.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67809 ; AAM67809 ; BUsg_250 .
GeneIDi 1005452.
KEGGi bas:BUsg250.
PATRICi 21247303. VBIBucAph100086_0261.

Phylogenomic databases

eggNOGi COG0681.
KOi K03100.
OMAi FKYPKDP.
OrthoDBi EOG6KDKTM.

Enzyme and pathway databases

BioCyci BAPH198804:GHMG-264-MONOMER.

Family and domain databases

Gene3Di 2.10.109.10. 2 hits.
2.170.230.10. 1 hit.
InterProi IPR000223. Pept_S26A_signal_pept_1.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR019533. Peptidase_S26.
IPR019766. Peptidase_S26A_all-beta_subdom.
[Graphical view ]
PANTHERi PTHR12383. PTHR12383. 1 hit.
Pfami PF00717. Peptidase_S24. 1 hit.
PF10502. Peptidase_S26. 1 hit.
[Graphical view ]
PRINTSi PR00727. LEADERPTASE.
SUPFAMi SSF51306. SSF51306. 1 hit.
TIGRFAMsi TIGR02227. sigpep_I_bact. 1 hit.
PROSITEi PS00501. SPASE_I_1. 1 hit.
PS00760. SPASE_I_2. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiLEP_BUCAP
AccessioniPrimary (citable) accession number: Q8K9R0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi