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Protein

Signal peptidase I

Gene

lepB

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88By similarity1
Active sitei142By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease

Enzyme and pathway databases

BioCyciBAPH198804:G1FZU-268-MONOMER

Protein family/group databases

MEROPSiS26.001

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase I (EC:3.4.21.89)
Short name:
SPase I
Alternative name(s):
Leader peptidase I
Gene namesi
Name:lepB
Ordered Locus Names:BUsg_250
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000416 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 63CytoplasmicSequence analysisAdd BLAST36
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 312ExtracellularSequence analysisAdd BLAST228

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001095041 – 312Signal peptidase IAdd BLAST312

Proteomic databases

PRIDEiQ8K9R0

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg250

Structurei

3D structure databases

ProteinModelPortaliQ8K9R0
SMRiQ8K9R0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C3F Bacteria
COG0681 LUCA
KOiK03100
OMAiGDMLFVK
OrthoDBiPOG091H023R

Family and domain databases

InterProiView protein in InterPro
IPR036286 LexA/Signal_pep-like_sf
IPR000223 Pept_S26A_signal_pept_1
IPR019758 Pept_S26A_signal_pept_1_CS
IPR019757 Pept_S26A_signal_pept_1_Lys-AS
IPR019756 Pept_S26A_signal_pept_1_Ser-AS
IPR015927 Peptidase_S24_S26A/B/C
IPR019533 Peptidase_S26
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
PF10502 Peptidase_S26, 1 hit
PRINTSiPR00727 LEADERPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02227 sigpep_I_bact, 1 hit
PROSITEiView protein in PROSITE
PS00501 SPASE_I_1, 1 hit
PS00760 SPASE_I_2, 1 hit
PS00761 SPASE_I_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K9R0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNILTIFLL TSTFFTGILW IIDHILLIKN YFYNKKKTKN NNTILINKVI
60 70 80 90 100
LENKKCFFRS LSSLFPTFFI VFIIRSFIYE PFQIPSGSMM PTLLIGDFIL
110 120 130 140 150
VKKFSYGIKE PITNKTIIKM NLPQRGDIVV FKHPKNNIDY IKRVVGLPGD
160 170 180 190 200
KIQYDINRKK IKICINYTNQ KNCENKLFIT YSKPKLSNFF QKIYLLKSRT
210 220 230 240 250
NEEEKVYNSI YFKKVEEKIN NLKHNILILD GINSKINDYY QQKGMPKLIW
260 270 280 290 300
IVPKNKYFMM GDNRDNSLDS RYWGFVPEEN LLGKATKIWM SFEKKENEWP
310
TGIRIKRIGN IY
Length:312
Mass (Da):37,103
Last modified:October 1, 2002 - v1
Checksum:i63602053A16A0D8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA Translation: AAM67809.1
RefSeqiWP_011053776.1, NC_004061.1

Genome annotation databases

EnsemblBacteriaiAAM67809; AAM67809; BUsg_250
KEGGibas:BUsg_250

Similar proteinsi

Entry informationi

Entry nameiLEP_BUCAP
AccessioniPrimary (citable) accession number: Q8K9R0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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