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Q8K9Q6

- FABI_BUCAP

UniProt

Q8K9Q6 - FABI_BUCAP

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Protein

Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

Gene

fabI

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis (By similarity).By similarity

Catalytic activityi

An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131NAD; via carbonyl oxygenBy similarity
Binding sitei40 – 401NADBy similarity
Binding sitei92 – 921NAD; via carbonyl oxygenBy similarity
Active sitei146 – 1461Proton acceptorBy similarity
Active sitei156 – 1561Proton acceptorBy similarity
Binding sitei163 – 1631NADBy similarity
Sitei201 – 2011Involved in acyl-ACP bindingBy similarity
Sitei204 – 2041Involved in acyl-ACP bindingBy similarity
Sitei205 – 2051Involved in acyl-ACP bindingBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 202NADBy similarity
Nucleotide bindingi64 – 652NADBy similarity
Nucleotide bindingi192 – 1965NADBy similarity

GO - Molecular functioni

  1. enoyl-[acyl-carrier-protein] reductase (NADH) activity Source: UniProtKB

GO - Biological processi

  1. biotin biosynthetic process Source: UniProtKB
  2. fatty acid elongation Source: UniProtKB
  3. protein homotetramerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Biotin biosynthesis, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-269-MONOMER.
UniPathwayiUPA00078.
UPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (EC:1.3.1.9)
Short name:
ENR
Alternative name(s):
NADH-dependent enoyl-ACP reductase
Gene namesi
Name:fabI
Ordered Locus Names:BUsg_255
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Enoyl-[acyl-carrier-protein] reductase [NADH] FabIPRO_0000054897Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi198804.BUsg255.

Structurei

3D structure databases

ProteinModelPortaliQ8K9Q6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0623.
KOiK00208.
OMAiGISGEIM.
OrthoDBiEOG6HF644.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR014358. Enoyl-ACP_Rdtase_NADH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PIRSFiPIRSF000094. Enoyl-ACP_rdct. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K9Q6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGILKGKKIL ITGILNEKSI AFGIAKSMYK QEAELIFVCQ NKKIINKIKY
60 70 80 90 100
LIKSINYNTI FFCDVSHDEN IKELFFNIKK VWNNFDGLVH SIAYCPKKQM
110 120 130 140 150
HEDFVESSSR KSFNICHEIS SYSFLSMARE CKNMLNKFSS LVTLSYLGSQ
160 170 180 190 200
KIVSNYNMMG LAKSSLEANV RYMANSLGKN NIRVNAISSG PIKTTSSYQI
210 220 230 240 250
KNFNKIQKIH KLFSLTKNHV SSEEIGNVAA FLCSDLSIGI TGSIINVDHG
260
FNLNGINSII
Length:260
Mass (Da):29,268
Last modified:October 1, 2002 - v1
Checksum:iB97D1279FEFD3C71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67813.1.
RefSeqiNP_660602.1. NC_004061.1.
WP_011053780.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67813; AAM67813; BUsg_255.
GeneIDi1005457.
KEGGibas:BUsg255.
PATRICi21247315. VBIBucAph100086_0267.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67813.1 .
RefSeqi NP_660602.1. NC_004061.1.
WP_011053780.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8K9Q6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg255.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67813 ; AAM67813 ; BUsg_255 .
GeneIDi 1005457.
KEGGi bas:BUsg255.
PATRICi 21247315. VBIBucAph100086_0267.

Phylogenomic databases

eggNOGi COG0623.
KOi K00208.
OMAi GISGEIM.
OrthoDBi EOG6HF644.

Enzyme and pathway databases

UniPathwayi UPA00078 .
UPA00094 .
BioCyci BAPH198804:GHMG-269-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR014358. Enoyl-ACP_Rdtase_NADH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PIRSFi PIRSF000094. Enoyl-ACP_rdct. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiFABI_BUCAP
AccessioniPrimary (citable) accession number: Q8K9Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: October 1, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3