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Q8K9N3

- ODO1_BUCAP

UniProt

Q8K9N3 - ODO1_BUCAP

Protein

2-oxoglutarate dehydrogenase E1 component

Gene

sucA

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-306-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
    Alternative name(s):
    Alpha-ketoglutarate dehydrogenase
    Gene namesi
    Name:sucA
    Ordered Locus Names:BUsg_292
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9239232-oxoglutarate dehydrogenase E1 componentPRO_0000162188Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi198804.BUsg292.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K9N3.
    SMRiQ8K9N3. Positions 82-921.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0567.
    KOiK00164.
    OMAiNEEERRW.
    OrthoDBiEOG6V1M1F.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8K9N3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKNTLEKWF NSSWLSGNNQ NYIEKIYESY LINPKSVDIT WQDKFSDLSK    50
    KRKNILKEEK FVYKNNSFKE IKIDKQEILE KKINYIINTF RKKGYKKSLI 100
    DPLKLNEQKK YKYLEPTFYH FSEDELKKTV KIDFKNSSQY EIKIRDLYEQ 150
    LNNKYCGSIG FEYMYIENSF EKKWITKHIE LFFKENLFIK KEKIRFLKEI 200
    LYGETFEKYL GKKFSGTKRF SLEGGETLIS ILHEIIRYSK KNDVSEIILG 250
    MAHRGRLNVL VNVLNKNPQV LFNEFSGINI PKEYSGDVKY HMGGITKIKN 300
    DKKKIYLKLA YNPSHLEIVN PVVLGIARAS INQLKISENK FLSINIHGDA 350
    SIIGQGVIQE TLNMSQTEAY KIGGTIHIVI NNQIGFTTSN PKNLRSSKYC 400
    TDVAKMIQAP VFHVNADDIE ASIFAIQLAL KFKKKFKKDV FIDLVCYRRH 450
    GHNEVDDPFV TQPIMYKKIH NHPTIGQIYS NLLISEKLIT SNDIEKIIEK 500
    YTTKLVQGKN VLSQERNITF QNGNKNFFIK KQKENTQLNF LNIKDLLYSI 550
    NTIPNSIEVH NRVKKIYQER IGMADGQILL DWGTAELLAY ATILKEGISC 600
    RLSGEDISRG TFFHRHAFIH DQNNGSIYVP LQNIEKNQGK FEIWDSVLSE 650
    EAVLAFEYGY SLFPSNNLTI WEAQFGDFAN GAQVVIDQFI SSSEQKWNQK 700
    SNLVLFLPHG YEGQGPEHSS ARLERFLQLC AENNIQVCIP TVSSQIFHLL 750
    RRQIFSNVYK PLIVLTPKSL LRNNVARSSL EVLVNENFKN VINEIDKNQK 800
    EVKRIIFCSG KIYYDLLEYR NKCDINNVLL IRIEQLYPFP KDEILTILKS 850
    YSYVQDFIWC QEEPHNQGAW FYIKDLLSTL LPLNSHLNYV SRPSAASPAA 900
    GHILIHRKEQ EKLINNAFNF KIA 923
    Length:923
    Mass (Da):107,422
    Last modified:October 1, 2002 - v1
    Checksum:i255A7653EED01A48
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67847.1.
    RefSeqiNP_660636.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67847; AAM67847; BUsg_292.
    GeneIDi1005496.
    KEGGibas:BUsg292.
    PATRICi21247393. VBIBucAph100086_0306.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67847.1 .
    RefSeqi NP_660636.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8K9N3.
    SMRi Q8K9N3. Positions 82-921.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg292.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67847 ; AAM67847 ; BUsg_292 .
    GeneIDi 1005496.
    KEGGi bas:BUsg292.
    PATRICi 21247393. VBIBucAph100086_0306.

    Phylogenomic databases

    eggNOGi COG0567.
    KOi K00164.
    OMAi NEEERRW.
    OrthoDBi EOG6V1M1F.

    Enzyme and pathway databases

    BioCyci BAPH198804:GHMG-306-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiODO1_BUCAP
    AccessioniPrimary (citable) accession number: Q8K9N3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3