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Q8K9N3

- ODO1_BUCAP

UniProt

Q8K9N3 - ODO1_BUCAP

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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

sucA

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-306-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Ordered Locus Names:BUsg_292
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9239232-oxoglutarate dehydrogenase E1 componentPRO_0000162188Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi198804.BUsg292.

Structurei

3D structure databases

ProteinModelPortaliQ8K9N3.
SMRiQ8K9N3. Positions 82-921.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
KOiK00164.
OMAiNEEERRW.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K9N3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKNTLEKWF NSSWLSGNNQ NYIEKIYESY LINPKSVDIT WQDKFSDLSK
60 70 80 90 100
KRKNILKEEK FVYKNNSFKE IKIDKQEILE KKINYIINTF RKKGYKKSLI
110 120 130 140 150
DPLKLNEQKK YKYLEPTFYH FSEDELKKTV KIDFKNSSQY EIKIRDLYEQ
160 170 180 190 200
LNNKYCGSIG FEYMYIENSF EKKWITKHIE LFFKENLFIK KEKIRFLKEI
210 220 230 240 250
LYGETFEKYL GKKFSGTKRF SLEGGETLIS ILHEIIRYSK KNDVSEIILG
260 270 280 290 300
MAHRGRLNVL VNVLNKNPQV LFNEFSGINI PKEYSGDVKY HMGGITKIKN
310 320 330 340 350
DKKKIYLKLA YNPSHLEIVN PVVLGIARAS INQLKISENK FLSINIHGDA
360 370 380 390 400
SIIGQGVIQE TLNMSQTEAY KIGGTIHIVI NNQIGFTTSN PKNLRSSKYC
410 420 430 440 450
TDVAKMIQAP VFHVNADDIE ASIFAIQLAL KFKKKFKKDV FIDLVCYRRH
460 470 480 490 500
GHNEVDDPFV TQPIMYKKIH NHPTIGQIYS NLLISEKLIT SNDIEKIIEK
510 520 530 540 550
YTTKLVQGKN VLSQERNITF QNGNKNFFIK KQKENTQLNF LNIKDLLYSI
560 570 580 590 600
NTIPNSIEVH NRVKKIYQER IGMADGQILL DWGTAELLAY ATILKEGISC
610 620 630 640 650
RLSGEDISRG TFFHRHAFIH DQNNGSIYVP LQNIEKNQGK FEIWDSVLSE
660 670 680 690 700
EAVLAFEYGY SLFPSNNLTI WEAQFGDFAN GAQVVIDQFI SSSEQKWNQK
710 720 730 740 750
SNLVLFLPHG YEGQGPEHSS ARLERFLQLC AENNIQVCIP TVSSQIFHLL
760 770 780 790 800
RRQIFSNVYK PLIVLTPKSL LRNNVARSSL EVLVNENFKN VINEIDKNQK
810 820 830 840 850
EVKRIIFCSG KIYYDLLEYR NKCDINNVLL IRIEQLYPFP KDEILTILKS
860 870 880 890 900
YSYVQDFIWC QEEPHNQGAW FYIKDLLSTL LPLNSHLNYV SRPSAASPAA
910 920
GHILIHRKEQ EKLINNAFNF KIA
Length:923
Mass (Da):107,422
Last modified:October 1, 2002 - v1
Checksum:i255A7653EED01A48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67847.1.
RefSeqiNP_660636.1. NC_004061.1.
WP_011053814.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67847; AAM67847; BUsg_292.
GeneIDi1005496.
KEGGibas:BUsg292.
PATRICi21247393. VBIBucAph100086_0306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67847.1 .
RefSeqi NP_660636.1. NC_004061.1.
WP_011053814.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8K9N3.
SMRi Q8K9N3. Positions 82-921.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg292.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67847 ; AAM67847 ; BUsg_292 .
GeneIDi 1005496.
KEGGi bas:BUsg292.
PATRICi 21247393. VBIBucAph100086_0306.

Phylogenomic databases

eggNOGi COG0567.
KOi K00164.
OMAi NEEERRW.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci BAPH198804:GHMG-306-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiODO1_BUCAP
AccessioniPrimary (citable) accession number: Q8K9N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3