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Q8K9N3

- ODO1_BUCAP

UniProt

Q8K9N3 - ODO1_BUCAP

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Protein

2-oxoglutarate dehydrogenase E1 component

Gene
sucA, BUsg_292
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-306-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Ordered Locus Names:BUsg_292
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9239232-oxoglutarate dehydrogenase E1 componentPRO_0000162188Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi198804.BUsg292.

Structurei

3D structure databases

ProteinModelPortaliQ8K9N3.
SMRiQ8K9N3. Positions 82-921.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
KOiK00164.
OMAiNEEERRW.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K9N3-1 [UniParc]FASTAAdd to Basket

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MKKNTLEKWF NSSWLSGNNQ NYIEKIYESY LINPKSVDIT WQDKFSDLSK    50
KRKNILKEEK FVYKNNSFKE IKIDKQEILE KKINYIINTF RKKGYKKSLI 100
DPLKLNEQKK YKYLEPTFYH FSEDELKKTV KIDFKNSSQY EIKIRDLYEQ 150
LNNKYCGSIG FEYMYIENSF EKKWITKHIE LFFKENLFIK KEKIRFLKEI 200
LYGETFEKYL GKKFSGTKRF SLEGGETLIS ILHEIIRYSK KNDVSEIILG 250
MAHRGRLNVL VNVLNKNPQV LFNEFSGINI PKEYSGDVKY HMGGITKIKN 300
DKKKIYLKLA YNPSHLEIVN PVVLGIARAS INQLKISENK FLSINIHGDA 350
SIIGQGVIQE TLNMSQTEAY KIGGTIHIVI NNQIGFTTSN PKNLRSSKYC 400
TDVAKMIQAP VFHVNADDIE ASIFAIQLAL KFKKKFKKDV FIDLVCYRRH 450
GHNEVDDPFV TQPIMYKKIH NHPTIGQIYS NLLISEKLIT SNDIEKIIEK 500
YTTKLVQGKN VLSQERNITF QNGNKNFFIK KQKENTQLNF LNIKDLLYSI 550
NTIPNSIEVH NRVKKIYQER IGMADGQILL DWGTAELLAY ATILKEGISC 600
RLSGEDISRG TFFHRHAFIH DQNNGSIYVP LQNIEKNQGK FEIWDSVLSE 650
EAVLAFEYGY SLFPSNNLTI WEAQFGDFAN GAQVVIDQFI SSSEQKWNQK 700
SNLVLFLPHG YEGQGPEHSS ARLERFLQLC AENNIQVCIP TVSSQIFHLL 750
RRQIFSNVYK PLIVLTPKSL LRNNVARSSL EVLVNENFKN VINEIDKNQK 800
EVKRIIFCSG KIYYDLLEYR NKCDINNVLL IRIEQLYPFP KDEILTILKS 850
YSYVQDFIWC QEEPHNQGAW FYIKDLLSTL LPLNSHLNYV SRPSAASPAA 900
GHILIHRKEQ EKLINNAFNF KIA 923
Length:923
Mass (Da):107,422
Last modified:October 1, 2002 - v1
Checksum:i255A7653EED01A48
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67847.1.
RefSeqiNP_660636.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67847; AAM67847; BUsg_292.
GeneIDi1005496.
KEGGibas:BUsg292.
PATRICi21247393. VBIBucAph100086_0306.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67847.1 .
RefSeqi NP_660636.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8K9N3.
SMRi Q8K9N3. Positions 82-921.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg292.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67847 ; AAM67847 ; BUsg_292 .
GeneIDi 1005496.
KEGGi bas:BUsg292.
PATRICi 21247393. VBIBucAph100086_0306.

Phylogenomic databases

eggNOGi COG0567.
KOi K00164.
OMAi NEEERRW.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci BAPH198804:GHMG-306-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiODO1_BUCAP
AccessioniPrimary (citable) accession number: Q8K9N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi