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Q8K9M2

- G6PD_BUCAP

UniProt

Q8K9M2 - G6PD_BUCAP

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei49 – 491NADPUniRule annotation
    Binding sitei146 – 1461NADPUniRule annotation
    Binding sitei176 – 1761SubstrateUniRule annotation
    Binding sitei180 – 1801SubstrateUniRule annotation
    Binding sitei214 – 2141SubstrateUniRule annotation
    Binding sitei233 – 2331SubstrateUniRule annotation
    Active sitei238 – 2381Proton acceptorUniRule annotation
    Binding sitei338 – 3381SubstrateUniRule annotation
    Binding sitei343 – 3431SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi91 – 922NADPUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-326-MONOMER.
    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
    Short name:
    G6PDUniRule annotation
    Gene namesi
    Name:zwfUniRule annotation
    Ordered Locus Names:BUsg_312
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Glucose-6-phosphate 1-dehydrogenasePRO_0000068113Add
    BLAST

    Proteomic databases

    PRIDEiQ8K9M2.

    Interactioni

    Protein-protein interaction databases

    STRINGi198804.BUsg312.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K9M2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0364.
    KOiK00036.
    OMAiDSIMEAW.
    OrthoDBiEOG61308Z.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K9M2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIIETNQACD LVIFGTKGDL ARRKLLPALY KLEKSQKIHP DTRIIGTGRA    50
    DWNTEDYIKI VKKAIKMFLN EKIDEKIWKK LRSRLNFFYI DVFQDLHFLE 100
    LKNILNQKKN IIIYYCAVPS NTFNAIFTGL GKVNLNSFPS RIIIEKPLGV 150
    SLETSKKINN QIAKYFLESQ IFRIDHYLGK ESILNLLALR FSNSFFFHSW 200
    NNKIIDHIQI TVSEEVGIEN RWNYFDQMGQ TRDMVQNHLL QILTIVSMDK 250
    PKNITPEGIR DEKLKILRSL KKIDLNEIHI KTARGQYASG IINGKKVPSY 300
    IEENGANKHS KTETFVSIKV DINNDRWFGV PFYLRTGKRL AYKYSEIVIV 350
    FKKISKNLFQ EFNKNLSPNK LIIRLEPNES IKIYFLNKVP GLSKEYKLKS 400
    DKMEFNFNIN NTKNFVDAYE RLLFESMRGI QSLFVCREEV EEAWKWIDPI 450
    INGWKKTNIN TVQLYKSGTW GPKSSDEIIM RDGRFWETFN 490
    Length:490
    Mass (Da):57,531
    Last modified:October 1, 2002 - v1
    Checksum:i8554072078E042D9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67866.1.
    RefSeqiNP_660655.1. NC_004061.1.
    WP_011053833.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67866; AAM67866; BUsg_312.
    GeneIDi1005516.
    KEGGibas:BUsg312.
    PATRICi21247431. VBIBucAph100086_0325.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67866.1 .
    RefSeqi NP_660655.1. NC_004061.1.
    WP_011053833.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8K9M2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg312.

    Proteomic databases

    PRIDEi Q8K9M2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67866 ; AAM67866 ; BUsg_312 .
    GeneIDi 1005516.
    KEGGi bas:BUsg312.
    PATRICi 21247431. VBIBucAph100086_0325.

    Phylogenomic databases

    eggNOGi COG0364.
    KOi K00036.
    OMAi DSIMEAW.
    OrthoDBi EOG61308Z.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .
    BioCyci BAPH198804:GHMG-326-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiG6PD_BUCAP
    AccessioniPrimary (citable) accession number: Q8K9M2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3