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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491NADPUniRule annotation
Binding sitei146 – 1461NADPUniRule annotation
Binding sitei176 – 1761SubstrateUniRule annotation
Binding sitei180 – 1801SubstrateUniRule annotation
Binding sitei214 – 2141SubstrateUniRule annotation
Binding sitei233 – 2331SubstrateUniRule annotation
Active sitei238 – 2381Proton acceptorUniRule annotation
Binding sitei338 – 3381SubstrateUniRule annotation
Binding sitei343 – 3431SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi91 – 922NADPUniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glucose metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-326-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:BUsg_312
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Glucose-6-phosphate 1-dehydrogenasePRO_0000068113Add
BLAST

Proteomic databases

PRIDEiQ8K9M2.

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg312.

Structurei

3D structure databases

ProteinModelPortaliQ8K9M2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0364.
KOiK00036.
OMAiVEPCTLA.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K9M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIETNQACD LVIFGTKGDL ARRKLLPALY KLEKSQKIHP DTRIIGTGRA
60 70 80 90 100
DWNTEDYIKI VKKAIKMFLN EKIDEKIWKK LRSRLNFFYI DVFQDLHFLE
110 120 130 140 150
LKNILNQKKN IIIYYCAVPS NTFNAIFTGL GKVNLNSFPS RIIIEKPLGV
160 170 180 190 200
SLETSKKINN QIAKYFLESQ IFRIDHYLGK ESILNLLALR FSNSFFFHSW
210 220 230 240 250
NNKIIDHIQI TVSEEVGIEN RWNYFDQMGQ TRDMVQNHLL QILTIVSMDK
260 270 280 290 300
PKNITPEGIR DEKLKILRSL KKIDLNEIHI KTARGQYASG IINGKKVPSY
310 320 330 340 350
IEENGANKHS KTETFVSIKV DINNDRWFGV PFYLRTGKRL AYKYSEIVIV
360 370 380 390 400
FKKISKNLFQ EFNKNLSPNK LIIRLEPNES IKIYFLNKVP GLSKEYKLKS
410 420 430 440 450
DKMEFNFNIN NTKNFVDAYE RLLFESMRGI QSLFVCREEV EEAWKWIDPI
460 470 480 490
INGWKKTNIN TVQLYKSGTW GPKSSDEIIM RDGRFWETFN
Length:490
Mass (Da):57,531
Last modified:September 30, 2002 - v1
Checksum:i8554072078E042D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67866.1.
RefSeqiNP_660655.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67866; AAM67866; BUsg_312.
GeneIDi1005516.
KEGGibas:BUsg312.
PATRICi21247431. VBIBucAph100086_0325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67866.1.
RefSeqiNP_660655.1. NC_004061.1.

3D structure databases

ProteinModelPortaliQ8K9M2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198804.BUsg312.

Proteomic databases

PRIDEiQ8K9M2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM67866; AAM67866; BUsg_312.
GeneIDi1005516.
KEGGibas:BUsg312.
PATRICi21247431. VBIBucAph100086_0325.

Phylogenomic databases

eggNOGiCOG0364.
KOiK00036.
OMAiVEPCTLA.
OrthoDBiEOG61308Z.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.
BioCyciBAPH198804:GHMG-326-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiG6PD_BUCAP
AccessioniPrimary (citable) accession number: Q8K9M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2002
Last sequence update: September 30, 2002
Last modified: March 3, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.