Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8K9M2 (G6PD_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-dehydrogenase

Short name=G6PD
EC=1.1.1.49
Gene names
Name:zwf
Ordered Locus Names:BUsg_312
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity. HAMAP-Rule MF_00966

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH. HAMAP-Rule MF_00966

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. HAMAP-Rule MF_00966

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNADP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glucose-6-phosphate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Glucose-6-phosphate 1-dehydrogenase HAMAP-Rule MF_00966
PRO_0000068113

Regions

Nucleotide binding91 – 922NADP By similarity

Sites

Active site2381Proton acceptor By similarity
Binding site491NADP By similarity
Binding site1461NADP By similarity
Binding site1761Substrate By similarity
Binding site1801Substrate By similarity
Binding site2141Substrate By similarity
Binding site2331Substrate By similarity
Binding site3381Substrate By similarity
Binding site3431Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8K9M2 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 8554072078E042D9

FASTA49057,531
        10         20         30         40         50         60 
MIIETNQACD LVIFGTKGDL ARRKLLPALY KLEKSQKIHP DTRIIGTGRA DWNTEDYIKI 

        70         80         90        100        110        120 
VKKAIKMFLN EKIDEKIWKK LRSRLNFFYI DVFQDLHFLE LKNILNQKKN IIIYYCAVPS 

       130        140        150        160        170        180 
NTFNAIFTGL GKVNLNSFPS RIIIEKPLGV SLETSKKINN QIAKYFLESQ IFRIDHYLGK 

       190        200        210        220        230        240 
ESILNLLALR FSNSFFFHSW NNKIIDHIQI TVSEEVGIEN RWNYFDQMGQ TRDMVQNHLL 

       250        260        270        280        290        300 
QILTIVSMDK PKNITPEGIR DEKLKILRSL KKIDLNEIHI KTARGQYASG IINGKKVPSY 

       310        320        330        340        350        360 
IEENGANKHS KTETFVSIKV DINNDRWFGV PFYLRTGKRL AYKYSEIVIV FKKISKNLFQ 

       370        380        390        400        410        420 
EFNKNLSPNK LIIRLEPNES IKIYFLNKVP GLSKEYKLKS DKMEFNFNIN NTKNFVDAYE 

       430        440        450        460        470        480 
RLLFESMRGI QSLFVCREEV EEAWKWIDPI INGWKKTNIN TVQLYKSGTW GPKSSDEIIM 

       490 
RDGRFWETFN 

« Hide

References

[1]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE013218 Genomic DNA. Translation: AAM67866.1.
RefSeqNP_660655.1. NC_004061.1.

3D structure databases

ProteinModelPortalQ8K9M2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198804.BUsg312.

Proteomic databases

PRIDEQ8K9M2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM67866; AAM67866; BUsg_312.
GeneID1005516.
KEGGbas:BUsg312.
PATRIC21247431. VBIBucAph100086_0325.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0364.
KOK00036.
OMALILETHH.
OrthoDBEOG61308Z.
ProtClustDBPRK05722.

Enzyme and pathway databases

BioCycBAPH198804:GHMG-326-MONOMER.
UniPathwayUPA00115; UER00408.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00966. G6PD.
InterProIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23429. PTHR23429. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
TIGRFAMsTIGR00871. zwf. 1 hit.
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PD_BUCAP
AccessionPrimary (citable) accession number: Q8K9M2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: February 19, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names