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Q8K9M2 (G6PD_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-dehydrogenase
Short name=G6PD
EC=1.1.1.49
Gene names
Name:zwf
Ordered Locus Names:BUsg_312
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera ›

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionNADP binding

Inferred from electronic annotation. Source: InterPro

glucose-6-phosphate dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Glucose-6-phosphate 1-dehydrogenase
PRO_0000068113

Sites

Active site2381Proton acceptor By similarity
Binding site171NADP By similarity
Binding site491NADP By similarity
Binding site1761Substrate By similarity
Binding site1801Substrate By similarity
Binding site3431Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8K9M2 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 8554072078E042D9

FASTA49057,531
        10         20         30         40         50         60 
MIIETNQACD LVIFGTKGDL ARRKLLPALY KLEKSQKIHP DTRIIGTGRA DWNTEDYIKI 

        70         80         90        100        110        120 
VKKAIKMFLN EKIDEKIWKK LRSRLNFFYI DVFQDLHFLE LKNILNQKKN IIIYYCAVPS 

       130        140        150        160        170        180 
NTFNAIFTGL GKVNLNSFPS RIIIEKPLGV SLETSKKINN QIAKYFLESQ IFRIDHYLGK 

       190        200        210        220        230        240 
ESILNLLALR FSNSFFFHSW NNKIIDHIQI TVSEEVGIEN RWNYFDQMGQ TRDMVQNHLL 

       250        260        270        280        290        300 
QILTIVSMDK PKNITPEGIR DEKLKILRSL KKIDLNEIHI KTARGQYASG IINGKKVPSY 

       310        320        330        340        350        360 
IEENGANKHS KTETFVSIKV DINNDRWFGV PFYLRTGKRL AYKYSEIVIV FKKISKNLFQ 

       370        380        390        400        410        420 
EFNKNLSPNK LIIRLEPNES IKIYFLNKVP GLSKEYKLKS DKMEFNFNIN NTKNFVDAYE 

       430        440        450        460        470        480 
RLLFESMRGI QSLFVCREEV EEAWKWIDPI INGWKKTNIN TVQLYKSGTW GPKSSDEIIM 

       490 
RDGRFWETFN

« Hide

References

[1]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE013218 Genomic DNA. Translation: AAM67866.1.
RefSeqNP_660655.1. NC_004061.1.

3D structure databases

ProteinModelPortalQ8K9M2.
ModBaseSearch...

Protein-protein interaction databases

STRING198804.BUsg312.

Proteomic databases

PRIDEQ8K9M2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM67866; AAM67866; BUsg_312.
GeneID1005516.
KEGGbas:BUsg312.
PATRIC21247431. VBIBucAph100086_0325.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0364.
KOK00036.
OMAHEAYLAM.
ProtClustDBPRK05722.

Enzyme and pathway databases

BioCycBAPH198804:GHMG-368-MONOMER.
UniPathwayUPA00115; UER00408.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23429. PTHR23429. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
TIGRFAMsTIGR00871. zwf. 1 hit.
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PD_BUCAP
AccessionPrimary (citable) accession number: Q8K9M2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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