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Protein

3-oxoacyl-[acyl-carrier-protein] reductase FabG

Gene

fabG

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.By similarity

Miscellaneous

Calcium ions stabilize the structure, and may inhibit FabG activity by obstructing access to the active site.By similarity

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37NADPBy similarity1
Metal bindingi50Calcium 1; via carbonyl oxygen; shared with dimeric partnerBy similarity1
Metal bindingi53Calcium 1; via carbonyl oxygen; shared with dimeric partnerBy similarity1
Binding sitei86NADP; via carbonyl oxygenBy similarity1
Binding sitei138SubstrateBy similarity1
Metal bindingi145Calcium 2By similarity1
Active sitei151Proton acceptorPROSITE-ProRule annotation1
Binding sitei184NADP; via amide nitrogen and carbonyl oxygenBy similarity1
Metal bindingi233Calcium 3; shared with dimeric partnerBy similarity1
Metal bindingi234Calcium 3; via carbonyl oxygen; shared with dimeric partnerBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 15NADPBy similarity4
Nucleotide bindingi59 – 60NADPBy similarity2
Nucleotide bindingi151 – 155NADPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandCalcium, Metal-binding, NADP

Enzyme and pathway databases

BioCyciBAPH198804:G1FZU-358-MONOMER
UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene namesi
Name:fabG
Ordered Locus Names:BUsg_339
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000416 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546671 – 2443-oxoacyl-[acyl-carrier-protein] reductase FabGAdd BLAST244

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi198804.BUsg339

Structurei

3D structure databases

ProteinModelPortaliQ8K9J5
SMRiQ8K9J5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CHR Bacteria
ENOG410XNW1 LUCA
KOiK00059
OMAiAVFQSPC
OrthoDBiPOG091H012M

Family and domain databases

InterProiView protein in InterPro
IPR011284 3oxo_ACP_reduc
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01830 3oxo_ACP_reduc, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K9J5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIEKKTALV TGANQGLGKE IAIKLSQKGI QVIGTSTTVD GVKTINKYLK
60 70 80 90 100
KNGFGFILDL KDTDSILEKM KEICQKKYSI DILINNAGIT SDNLLVYMSN
110 120 130 140 150
KEWENVIKIN LTSVFYMSKS VIRSMIKKRY GRIVTIGSVI GYLGNRGQIN
160 170 180 190 200
YSASKSGLIG FHKSLALEVA QKGITVNIVS PGFIKTNLTK NLNVFQYKKH
210 220 230 240
LSKIPMKRIG TAEEIANAVI FLSSEKASYI TGQTIHVNGG MYMT
Length:244
Mass (Da):26,939
Last modified:October 1, 2002 - v1
Checksum:i14526C91CDC54D5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA Translation: AAM67893.1
RefSeqiWP_011053860.1, NC_004061.1

Genome annotation databases

EnsemblBacteriaiAAM67893; AAM67893; BUsg_339
KEGGibas:BUsg_339

Similar proteinsi

Entry informationi

Entry nameiFABG_BUCAP
AccessioniPrimary (citable) accession number: Q8K9J5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health