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Protein

Thymidylate kinase

Gene

tmk

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 188ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidylate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTDP biosynthetic process Source: InterPro
  2. dTTP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-358-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:BUsg_341
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Thymidylate kinasePRO_0000155250Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg341.

Structurei

3D structure databases

ProteinModelPortaliQ8K9J3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0125.
KOiK00943.
OMAiDFFHRTR.
OrthoDBiEOG64JFSH.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K9J3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKSKFIVIE GLEGAGKTHA CICVQRILKE NNIKNVILVR QPGSTPVAEK
60 70 80 90 100
IRKLIKNNTY IEDFEKETEL LLMYAARIQL VKKIIQPALK KGTWVISDRH
110 120 130 140 150
DLSSLAYQGG GLGIKRKLIN KLKYLFLQDF IPDLTIYLDV YPEIGLKRAS
160 170 180 190 200
KRNHLDRIEH RSLTFFKKTR ASYLKNIKLD KKIIKINANL NIKIVTQNIK
210
NQILKWLQQK VV
Length:212
Mass (Da):24,547
Last modified:November 8, 2002 - v2
Checksum:i553CBBDE30E4C14A
GO

Sequence cautioni

The sequence AAM67895.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67895.1. Different initiation.
RefSeqiNP_660684.1. NC_004061.1.
WP_011053862.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67895; AAM67895; BUsg_341.
GeneIDi1005576.
KEGGibas:BUsg341.
PATRICi21247497. VBIBucAph100086_0355.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67895.1. Different initiation.
RefSeqiNP_660684.1. NC_004061.1.
WP_011053862.1. NC_004061.1.

3D structure databases

ProteinModelPortaliQ8K9J3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198804.BUsg341.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM67895; AAM67895; BUsg_341.
GeneIDi1005576.
KEGGibas:BUsg341.
PATRICi21247497. VBIBucAph100086_0355.

Phylogenomic databases

eggNOGiCOG0125.
KOiK00943.
OMAiDFFHRTR.
OrthoDBiEOG64JFSH.

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-358-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiKTHY_BUCAP
AccessioniPrimary (citable) accession number: Q8K9J3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: March 4, 2015
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.