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Q8K9J3

- KTHY_BUCAP

UniProt

Q8K9J3 - KTHY_BUCAP

Protein

Thymidylate kinase

Gene

tmk

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 2 (08 Nov 2002)
      Previous versions | rss
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    Functioni

    Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

    Catalytic activityi

    ATP + dTMP = ADP + dTDP.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 188ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidylate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTDP biosynthetic process Source: InterPro
    2. dTTP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-358-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
    Alternative name(s):
    dTMP kinaseUniRule annotation
    Gene namesi
    Name:tmkUniRule annotation
    Ordered Locus Names:BUsg_341
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 212212Thymidylate kinasePRO_0000155250Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi198804.BUsg341.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K9J3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0125.
    KOiK00943.
    OMAiEPGGCPI.
    OrthoDBiEOG64JFSH.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00165. Thymidylate_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR018095. Thymidylate_kin_CS.
    IPR018094. Thymidylate_kinase.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
    PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K9J3-1 [UniParc]FASTAAdd to Basket

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    MIKSKFIVIE GLEGAGKTHA CICVQRILKE NNIKNVILVR QPGSTPVAEK    50
    IRKLIKNNTY IEDFEKETEL LLMYAARIQL VKKIIQPALK KGTWVISDRH 100
    DLSSLAYQGG GLGIKRKLIN KLKYLFLQDF IPDLTIYLDV YPEIGLKRAS 150
    KRNHLDRIEH RSLTFFKKTR ASYLKNIKLD KKIIKINANL NIKIVTQNIK 200
    NQILKWLQQK VV 212
    Length:212
    Mass (Da):24,547
    Last modified:November 8, 2002 - v2
    Checksum:i553CBBDE30E4C14A
    GO

    Sequence cautioni

    The sequence AAM67895.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67895.1. Different initiation.
    RefSeqiNP_660684.1. NC_004061.1.
    WP_011053862.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67895; AAM67895; BUsg_341.
    GeneIDi1005576.
    KEGGibas:BUsg341.
    PATRICi21247497. VBIBucAph100086_0355.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67895.1 . Different initiation.
    RefSeqi NP_660684.1. NC_004061.1.
    WP_011053862.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8K9J3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg341.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67895 ; AAM67895 ; BUsg_341 .
    GeneIDi 1005576.
    KEGGi bas:BUsg341.
    PATRICi 21247497. VBIBucAph100086_0355.

    Phylogenomic databases

    eggNOGi COG0125.
    KOi K00943.
    OMAi EPGGCPI.
    OrthoDBi EOG64JFSH.

    Enzyme and pathway databases

    BioCyci BAPH198804:GHMG-358-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00165. Thymidylate_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR018095. Thymidylate_kin_CS.
    IPR018094. Thymidylate_kinase.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00041. DTMP_kinase. 1 hit.
    PROSITEi PS01331. THYMIDYLATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiKTHY_BUCAP
    AccessioniPrimary (citable) accession number: Q8K9J3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: November 8, 2002
    Last modified: October 1, 2014
    This is version 72 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3