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Q8K9J3 (KTHY_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidylate kinase

EC=2.7.4.9
Alternative name(s):
dTMP kinase
Gene names
Name:tmk
Ordered Locus Names:BUsg_341
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity. HAMAP-Rule MF_00165

Catalytic activity

ATP + dTMP = ADP + dTDP. HAMAP-Rule MF_00165

Sequence similarities

Belongs to the thymidylate kinase family.

Sequence caution

The sequence AAM67895.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processdTDP biosynthetic process

Inferred from electronic annotation. Source: InterPro

dTTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidylate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212Thymidylate kinase HAMAP-Rule MF_00165
PRO_0000155250

Regions

Nucleotide binding11 – 188ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q8K9J3 [UniParc].

Last modified November 8, 2002. Version 2.
Checksum: 553CBBDE30E4C14A

FASTA21224,547
        10         20         30         40         50         60 
MIKSKFIVIE GLEGAGKTHA CICVQRILKE NNIKNVILVR QPGSTPVAEK IRKLIKNNTY 

        70         80         90        100        110        120 
IEDFEKETEL LLMYAARIQL VKKIIQPALK KGTWVISDRH DLSSLAYQGG GLGIKRKLIN 

       130        140        150        160        170        180 
KLKYLFLQDF IPDLTIYLDV YPEIGLKRAS KRNHLDRIEH RSLTFFKKTR ASYLKNIKLD 

       190        200        210 
KKIIKINANL NIKIVTQNIK NQILKWLQQK VV 

« Hide

References

[1]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE013218 Genomic DNA. Translation: AAM67895.1. Different initiation.
RefSeqNP_660684.1. NC_004061.1.

3D structure databases

ProteinModelPortalQ8K9J3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198804.BUsg341.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM67895; AAM67895; BUsg_341.
GeneID1005576.
KEGGbas:BUsg341.
PATRIC21247497. VBIBucAph100086_0355.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0125.
KOK00943.
OMAMEAILFA.
OrthoDBEOG64JFSH.
ProtClustDBPRK00698.

Enzyme and pathway databases

BioCycBAPH198804:GHMG-358-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00165. Thymidylate_kinase.
InterProIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00041. DTMP_kinase. 1 hit.
PROSITEPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKTHY_BUCAP
AccessionPrimary (citable) accession number: Q8K9J3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: April 16, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names