Q8K9J3 (KTHY_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidylate kinase
EC=2.7.4.9

Alternative name(s):
dTMP kinase

Gene names

Name:	tmk
Ordered Locus Names:	BUsg_341

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Schizaphis graminum)

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity. HAMAP-Rule MF_00165
Catalytic activity	ATP + dTMP = ADP + dTDP. HAMAP-Rule MF_00165
Sequence similarities	Belongs to the thymidylate kinase family.
Sequence caution	The sequence AAM67895.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dTDP biosynthetic process Inferred from electronic annotation. Source: InterPro dTTP biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Thymidylate kinase HAMAP-Rule MF_00165		PRO_0000155250
Regions
	Nucleotide binding	11 – 18	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8K9J3 [UniParc]. Last modified November 8, 2002. Version 2. Checksum: 553CBBDE30E4C14A	FASTA	212	24,547
	10 20 30 40 50 60 MIKSKFIVIE GLEGAGKTHA CICVQRILKE NNIKNVILVR QPGSTPVAEK IRKLIKNNTY 70 80 90 100 110 120 IEDFEKETEL LLMYAARIQL VKKIIQPALK KGTWVISDRH DLSSLAYQGG GLGIKRKLIN 130 140 150 160 170 180 KLKYLFLQDF IPDLTIYLDV YPEIGLKRAS KRNHLDRIEH RSLTFFKKTR ASYLKNIKLD 190 200 210 KKIIKINANL NIKIVTQNIK NQILKWLQQK VV

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013218 Genomic DNA. Translation: AAM67895.1. Different initiation.
RefSeq	NP_660684.1. NC_004061.1.
3D structure databases
ProteinModelPortal	Q8K9J3.
ModBase	Search...
Protein-protein interaction databases
STRING	198804.BUsg341.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM67895; AAM67895; BUsg_341.
GeneID	1005576.
KEGG	bas:BUsg341.
PATRIC	21247497. VBIBucAph100086_0355.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0125.
KO	K00943.
OMA	ITLEGPE.
ProtClustDB	PRK00698.
Enzyme and pathway databases
BioCyc	BAPH198804:GHMG-397-MONOMER.
Family and domain databases
HAMAP	MF_00165. Thymidylate_kinase.
InterPro	IPR018095. Thymidylate_kin_CS. IPR018094. Thymidylate_kinase. [Graphical view]
PANTHER	PTHR10344. PTHR10344. 1 hit.
TIGRFAMs	TIGR00041. DTMP_kinase. 1 hit.
PROSITE	PS01331. THYMIDYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KTHY_BUCAP

Accession

Primary (citable) accession number: Q8K9J3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	November 8, 2002
Last modified:	May 1, 2013
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program