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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciBAPH198804:G1FZU-368-MONOMER
UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:BUsg_349
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000416 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002058241 – 398Nicotinate phosphoribosyltransferaseAdd BLAST398

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg349

Structurei

3D structure databases

ProteinModelPortaliQ8K9I6
SMRiQ8K9I6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RH7 Bacteria
COG1488 LUCA
KOiK00763
OMAiKLTMQCA
OrthoDBiPOG091H0197

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K9I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQYNYPIVK TLLDTDAYKF YMQQAVFYHY KNVDVVAEFI CRGPNILGCY
60 70 80 90 100
SHILLDQINM MSSLSLSHEE YLYMTTFPFF KKEYLHWLKK FRYNITQVKV
110 120 130 140 150
DNYHGQLHIR ISGLWKEVIL WEVPILSLIS EIFHRHCYPE ITSNIAVQHL
160 170 180 190 200
NKKLKEFFKK NRDVDLSRLK IVDFGTRRRF SYDVQYSIIK RLKDTFPFLI
210 220 230 240 250
GSSNYHISRI LKLLPVGTQA HEWFQAHQQI SSNLRNSQTL ALKTWLSQYN
260 270 280 290 300
QHLSIALTDC ITMDSFLRDF NLFFSKSYQG IRHDSGDPVK WGEKAIEHYE
310 320 330 340 350
RLGIDPTTKT LLFSDNLNFR KMISLYKKFN NRVNIIFGIG TKLTCDIPNV
360 370 380 390
KPLNIVIKLV KCNGKPVAKL SDSPGKTFCL DRNFIKSLCK AFDLSLTV
Length:398
Mass (Da):46,777
Last modified:October 1, 2002 - v1
Checksum:i19B29A2C1C6937CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA Translation: AAM67902.1
RefSeqiWP_011053869.1, NC_004061.1

Genome annotation databases

EnsemblBacteriaiAAM67902; AAM67902; BUsg_349
KEGGibas:BUsg_349

Similar proteinsi

Entry informationi

Entry nameiPNCB_BUCAP
AccessioniPrimary (citable) accession number: Q8K9I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: April 25, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health