Reviewed, UniProtKB/Swiss-Prot Q8K9H9 (PYRB_BUCAP)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	BUsg_357

Organism

Buchnera aphidicola subsp. Schizaphis graminum [Complete proteome] [HAMAP]

Taxonomic identifier

98794 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000113111

Sequences

	Sequence		Length	Mass (Da)
	Q8K9H9-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 4225C7BDDE2C11BD	FASTA	311	35,315
	10 20 30 40 50 60 MRNSLYKKNI ISISDLNQNE LELVLKKSAF LKVKAQPNLL KNKIIASCFF EASTRTRLSF 70 80 90 100 110 120 ETAVHRLGAS IIGFSDGSNI SLGKKGETLS DTISVISSYV DAIIIRHPQE GSARLAAQFS 130 140 150 160 170 180 NGVPIFNAGD GANQHPTQTL LDLFTIKETQ NKLNNLNIAM VGDLKYGRTV HSLTQALAKY 190 200 210 220 230 240 KNNQFFFVSP DSLTMPNYIN DMLYKKEIHW KRYKNIEEII SEIDILYMTR VQKERLDSTE 250 260 270 280 290 300 YASAKSKFVL QTSTLKNARN NLKILHPLPR IDEIDNNVDF TPYAWYFKQA ANGIYARQAI 310 LSLVLIEKHF E

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE013218 Genomic DNA. Translation: AAM67910.1.
RefSeq	NP_660699.1.
3D structure databases
HSSP	HSSP built from PDB template 1GQ3 based on UniProtKB P00479.
ModBase	Search...
Genome annotation databases
GeneID	1005798.
GenomeReviews	Gene locus BUsg_357 in contig AE013218_GR.
KEGG	bas:BUsg357.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8K9H9.
OMA	Q8K9H9. LYTIREN.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG357-MON.
Family and domain databases
HAMAP	MF_00001. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Aspartate_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_BUCAP

Accession

Primary (citable) accession number: Q8K9H9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)