Q8K9H9 (PYRB_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	BUsg_357

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000113111

Sequences

	Sequence		Length	Mass (Da)
	Q8K9H9 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 4225C7BDDE2C11BD	FASTA	311	35,315
	10 20 30 40 50 60 MRNSLYKKNI ISISDLNQNE LELVLKKSAF LKVKAQPNLL KNKIIASCFF EASTRTRLSF 70 80 90 100 110 120 ETAVHRLGAS IIGFSDGSNI SLGKKGETLS DTISVISSYV DAIIIRHPQE GSARLAAQFS 130 140 150 160 170 180 NGVPIFNAGD GANQHPTQTL LDLFTIKETQ NKLNNLNIAM VGDLKYGRTV HSLTQALAKY 190 200 210 220 230 240 KNNQFFFVSP DSLTMPNYIN DMLYKKEIHW KRYKNIEEII SEIDILYMTR VQKERLDSTE 250 260 270 280 290 300 YASAKSKFVL QTSTLKNARN NLKILHPLPR IDEIDNNVDF TPYAWYFKQA ANGIYARQAI 310 LSLVLIEKHF E

References

[1]	"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013218 Genomic DNA. Translation: AAM67910.1.
RefSeq	NP_660699.1. NC_004061.1.
3D structure databases
ProteinModelPortal	Q8K9H9.
SMR	Q8K9H9. Positions 3-305.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBUCT00000000481; EBBUCP00000000481; EBBUCG00000000481.
GeneID	1005798.
GenomeReviews	Gene locus BUsg_357 in contig AE013218_GR.
KEGG	bas:BUsg357.
PATRIC	21247529. VBIBucAph100086_0371.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000007871.
HOGENOM	HBG579429.
OMA	ADRYENT.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG357-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_BUCAP

Accession

Primary (citable) accession number: Q8K9H9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program