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Q8K9G4 (MURA_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase

EC=2.5.1.7
Alternative name(s):
Enoylpyruvate transferase
UDP-N-acetylglucosamine enolpyruvyl transferase
Short name=EPT
Gene names
Name:murA
Ordered Locus Names:BUsg_373
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. HAMAP-Rule MF_00111

Catalytic activity

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine. HAMAP-Rule MF_00111

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00111

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00111.

Sequence similarities

Belongs to the EPSP synthase family. MurA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 417417UDP-N-acetylglucosamine 1-carboxyvinyltransferase HAMAP-Rule MF_00111
PRO_0000178854

Sites

Active site1161Proton donor By similarity

Amino acid modifications

Modified residue11612-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8K9G4 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: B6C9BB89DFD38317

FASTA41745,757
        10         20         30         40         50         60 
MNKLYIEGDK KLNGNVIISG SKNAALPILF MTILTEKKIK ISNVPKLRDI NIAIQLLKSL 

        70         80         90        100        110        120 
GAQIKYKKKN LYIDTSSIKI HSPPYDLTKQ IRASIWMLAP LLIRFGKAKI FLPGGCKIGA 

       130        140        150        160        170        180 
RPIDLHIKGL IALGAKIILE KNYISASIKK PLTGKRIYIE KISVGATITV MSAATLAQGT 

       190        200        210        220        230        240 
TIIENAAQEP EIIDTAKFLN TLGANIIGAG SNRIFIKGVL TLIGGKHKII PDRIETGTFL 

       250        260        270        280        290        300 
IAAAISKGYI ICHDTEPKYL KNVLMKLSES GAEIKTGKDW IQLDMRGKKP KSINISTSPY 

       310        320        330        340        350        360 
PGFPTDMQPQ FALLNSISQS KGTITENIFE NRFIYTSELI KMGAKIKIKN NSIVCKGVPN 

       370        380        390        400        410 
LYSQNVFSND LRGSATLVLA GCIARGTTTV DNIHHFERGY EAFSEKLNKL GANIKYI 

« Hide

References

[1]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE013218 Genomic DNA. Translation: AAM67925.1.
RefSeqNP_660714.1. NC_004061.1.

3D structure databases

ProteinModelPortalQ8K9G4.
SMRQ8K9G4. Positions 1-417.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198804.BUsg373.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM67925; AAM67925; BUsg_373.
GeneID1005784.
KEGGbas:BUsg373.
PATRIC21247564. VBIBucAph100086_0387.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0766.
KOK00790.
OMAHGLEQMG.
OrthoDBEOG68M4GK.

Enzyme and pathway databases

BioCycBAPH198804:GHMG-391-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.65.10.10. 2 hits.
HAMAPMF_00111. MurA.
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMSSF55205. SSF55205. 1 hit.
TIGRFAMsTIGR01072. murA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURA_BUCAP
AccessionPrimary (citable) accession number: Q8K9G4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names