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Protein

P-protein

Gene

pheA

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

Chorismate = prephenate.
Prephenate = phenylpyruvate + H2O + CO2.

Pathwayi: L-phenylalanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phenylpyruvate from prephenate.
Proteins known to be involved in this subpathway in this organism are:
  1. P-protein (pheA)
This subpathway is part of the pathway L-phenylalanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phenylpyruvate from prephenate, the pathway L-phenylalanine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: prephenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes prephenate from chorismate.
Proteins known to be involved in this subpathway in this organism are:
  1. P-protein (pheA)
This subpathway is part of the pathway prephenate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes prephenate from chorismate, the pathway prephenate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei278Essential for prephenate dehydratase activitySequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Isomerase, Lyase, Multifunctional enzyme
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Phenylalanine biosynthesis

Enzyme and pathway databases

BioCyciBAPH198804:G1FZU-398-MONOMER
UniPathwayiUPA00120; UER00203
UPA00121; UER00345

Names & Taxonomyi

Protein namesi
Recommended name:
P-protein
Including the following 2 domains:
Chorismate mutase (EC:5.4.99.5)
Short name:
CM
Prephenate dehydratase (EC:4.2.1.51)
Short name:
PDT
Gene namesi
Name:pheA
Ordered Locus Names:BUsg_379
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000416 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001191831 – 385P-proteinAdd BLAST385

Proteomic databases

PRIDEiQ8K9F8

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg379

Structurei

3D structure databases

ProteinModelPortaliQ8K9F8
SMRiQ8K9F8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 92Chorismate mutasePROSITE-ProRule annotationAdd BLAST92
Domaini105 – 285Prephenate dehydratasePROSITE-ProRule annotationAdd BLAST181
Domaini299 – 376ACTPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni286 – 385RegulatoryAdd BLAST100

Domaini

The regulatory domain shows changes in the ESRP sequence, which is involved in the allosteric binding of phenylalanine. These changes suggest the desensitization of the enzyme to inhibition by phenylalanine and would permit the overproduction of phenylalanine.

Phylogenomic databases

eggNOGiENOG4105CQC Bacteria
COG0077 LUCA
COG1605 LUCA
KOiK14170
OMAiREVMSAC
OrthoDBiPOG091H027S

Family and domain databases

Gene3Di1.20.59.10, 1 hit
InterProiView protein in InterPro
IPR002912 ACT_dom
IPR008242 Chor_mutase/pphenate_deHydtase
IPR036263 Chorismate_II_sf
IPR036979 CM_dom_sf
IPR002701 CM_II_prokaryot
IPR010952 CM_P_1
IPR001086 Preph_deHydtase
IPR018528 Preph_deHydtase_CS
PfamiView protein in Pfam
PF01817 CM_2, 1 hit
PF00800 PDT, 1 hit
PIRSFiPIRSF001500 Chor_mut_pdt_Ppr, 1 hit
SMARTiView protein in SMART
SM00830 CM_2, 1 hit
SUPFAMiSSF48600 SSF48600, 1 hit
TIGRFAMsiTIGR01797 CM_P_1, 1 hit
PROSITEiView protein in PROSITE
PS51671 ACT, 1 hit
PS51168 CHORISMATE_MUT_2, 1 hit
PS00857 PREPHENATE_DEHYDR_1, 1 hit
PS51171 PREPHENATE_DEHYDR_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K9F8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSKNDLLSF RSEINNIDKN IVQLLAKRKK LVLNIAESKI KNNQPIRDIE
60 70 80 90 100
REKILLEKLT NLGKKNNLNT NYITRLFQLI IEESVLTQKK LLNKFCNDNN
110 120 130 140 150
LDLASFSFLG PKGSYSHIAA SQYAEQNFKT CIENACLSFN EVIQSVENNQ
160 170 180 190 200
TDYAVLPIEN SCSGFINEIF DILKKTNLFI IGEINISINH CLLAIKKIEL
210 220 230 240 250
NKIKAVYSHP QPFQQCSYFI KKFPNWKIQY TNSTADAMKK IVKYNITTNA
260 270 280 290 300
ALGSELGSKI YGLKVLYKNL ANKKKNITRF ILLSRKPVSI SSKIPTKTTL
310 320 330 340 350
IFNTGQESGA LAEVLLILKK NKLIMKKLTS QNIYKNPWEE MFYIDVQANL
360 370 380
SSSLMQETLE KIGKITKFIK ILGCYPSENI TPIIP
Length:385
Mass (Da):43,888
Last modified:October 1, 2002 - v1
Checksum:iE8ED3D4C4B05F48F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA Translation: AAM67931.1
RefSeqiWP_011053898.1, NC_004061.1

Genome annotation databases

EnsemblBacteriaiAAM67931; AAM67931; BUsg_379
KEGGibas:BUsg_379

Similar proteinsi

Entry informationi

Entry nameiPHEA_BUCAP
AccessioniPrimary (citable) accession number: Q8K9F8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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