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Q8K9F8

- PHEA_BUCAP

UniProt

Q8K9F8 - PHEA_BUCAP

Protein

P-protein

Gene

pheA

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Chorismate = prephenate.
    Prephenate = phenylpyruvate + H2O + CO2.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei278 – 2781Essential for prephenate dehydratase activitySequence Analysis

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. chorismate mutase activity Source: UniProtKB-EC
    3. prephenate dehydratase activity Source: UniProtKB-EC

    GO - Biological processi

    1. chorismate metabolic process Source: InterPro
    2. L-phenylalanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase, Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Phenylalanine biosynthesis

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-397-MONOMER.
    UniPathwayiUPA00120; UER00203.
    UPA00121; UER00345.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    P-protein
    Including the following 2 domains:
    Chorismate mutase (EC:5.4.99.5)
    Short name:
    CM
    Prephenate dehydratase (EC:4.2.1.51)
    Short name:
    PDT
    Gene namesi
    Name:pheA
    Ordered Locus Names:BUsg_379
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 385385P-proteinPRO_0000119183Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi198804.BUsg379.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K9F8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 9292Chorismate mutasePROSITE-ProRule annotationAdd
    BLAST
    Domaini105 – 285181Prephenate dehydratasePROSITE-ProRule annotationAdd
    BLAST
    Domaini299 – 37678ACTPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni286 – 385100RegulatoryAdd
    BLAST

    Domaini

    The regulatory domain shows changes in the ESRP sequence, which is involved in the allosteric binding of phenylalanine. These changes suggest the desensitization of the enzyme to inhibition by phenylalanine and would permit the overproduction of phenylalanine.

    Sequence similaritiesi

    Contains 1 ACT domain.PROSITE-ProRule annotation
    Contains 1 chorismate mutase domain.PROSITE-ProRule annotation
    Contains 1 prephenate dehydratase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0077.
    KOiK14170.
    OMAiIDVQANL.
    OrthoDBiEOG6WHNT1.

    Family and domain databases

    Gene3Di1.20.59.10. 1 hit.
    InterProiIPR002912. ACT_dom.
    IPR008242. Chor_mutase/pphenate_deHydtase.
    IPR002701. Chorismate_mutase.
    IPR020822. Chorismate_mutase_type_II.
    IPR010952. CM_P_1.
    IPR001086. Preph_deHydtase.
    IPR018528. Preph_deHydtase_CS.
    [Graphical view]
    PfamiPF01817. CM_2. 1 hit.
    PF00800. PDT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001500. Chor_mut_pdt_Ppr. 1 hit.
    SMARTiSM00830. CM_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48600. SSF48600. 1 hit.
    TIGRFAMsiTIGR01797. CM_P_1. 1 hit.
    PROSITEiPS51671. ACT. 1 hit.
    PS51168. CHORISMATE_MUT_2. 1 hit.
    PS00857. PREPHENATE_DEHYDR_1. 1 hit.
    PS51171. PREPHENATE_DEHYDR_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K9F8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSKNDLLSF RSEINNIDKN IVQLLAKRKK LVLNIAESKI KNNQPIRDIE    50
    REKILLEKLT NLGKKNNLNT NYITRLFQLI IEESVLTQKK LLNKFCNDNN 100
    LDLASFSFLG PKGSYSHIAA SQYAEQNFKT CIENACLSFN EVIQSVENNQ 150
    TDYAVLPIEN SCSGFINEIF DILKKTNLFI IGEINISINH CLLAIKKIEL 200
    NKIKAVYSHP QPFQQCSYFI KKFPNWKIQY TNSTADAMKK IVKYNITTNA 250
    ALGSELGSKI YGLKVLYKNL ANKKKNITRF ILLSRKPVSI SSKIPTKTTL 300
    IFNTGQESGA LAEVLLILKK NKLIMKKLTS QNIYKNPWEE MFYIDVQANL 350
    SSSLMQETLE KIGKITKFIK ILGCYPSENI TPIIP 385
    Length:385
    Mass (Da):43,888
    Last modified:October 1, 2002 - v1
    Checksum:iE8ED3D4C4B05F48F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67931.1.
    RefSeqiNP_660720.1. NC_004061.1.
    WP_011053898.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67931; AAM67931; BUsg_379.
    GeneIDi1005778.
    KEGGibas:BUsg379.
    PATRICi21247576. VBIBucAph100086_0393.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67931.1 .
    RefSeqi NP_660720.1. NC_004061.1.
    WP_011053898.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8K9F8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg379.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67931 ; AAM67931 ; BUsg_379 .
    GeneIDi 1005778.
    KEGGi bas:BUsg379.
    PATRICi 21247576. VBIBucAph100086_0393.

    Phylogenomic databases

    eggNOGi COG0077.
    KOi K14170.
    OMAi IDVQANL.
    OrthoDBi EOG6WHNT1.

    Enzyme and pathway databases

    UniPathwayi UPA00120 ; UER00203 .
    UPA00121 ; UER00345 .
    BioCyci BAPH198804:GHMG-397-MONOMER.

    Family and domain databases

    Gene3Di 1.20.59.10. 1 hit.
    InterProi IPR002912. ACT_dom.
    IPR008242. Chor_mutase/pphenate_deHydtase.
    IPR002701. Chorismate_mutase.
    IPR020822. Chorismate_mutase_type_II.
    IPR010952. CM_P_1.
    IPR001086. Preph_deHydtase.
    IPR018528. Preph_deHydtase_CS.
    [Graphical view ]
    Pfami PF01817. CM_2. 1 hit.
    PF00800. PDT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001500. Chor_mut_pdt_Ppr. 1 hit.
    SMARTi SM00830. CM_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48600. SSF48600. 1 hit.
    TIGRFAMsi TIGR01797. CM_P_1. 1 hit.
    PROSITEi PS51671. ACT. 1 hit.
    PS51168. CHORISMATE_MUT_2. 1 hit.
    PS00857. PREPHENATE_DEHYDR_1. 1 hit.
    PS51171. PREPHENATE_DEHYDR_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiPHEA_BUCAP
    AccessioniPrimary (citable) accession number: Q8K9F8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome, Multifunctional enzyme

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3