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Q8K9D8 (QUED_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
6-carboxy-5,6,7,8-tetrahydropterin synthase

Short name=CPH4 synthase
EC=4.1.2.50
Alternative name(s):
Queuosine biosynthesis protein QueD
Gene names
Name:queD
Ordered Locus Names:BUsg_402
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length120 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde By similarity.

Catalytic activity

7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.

Miscellaneous

The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit By similarity.

Sequence similarities

Belongs to the PTPS family. QueD subfamily.

Ontologies

Keywords
   Biological processQueuosine biosynthesis
   LigandMetal-binding
Zinc
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processqueuosine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlyase activity

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1201206-carboxy-5,6,7,8-tetrahydropterin synthase
PRO_0000057921

Sites

Active site261Proton acceptor By similarity
Active site701Charge relay system By similarity
Active site1091Charge relay system By similarity
Metal binding151Zinc By similarity
Metal binding301Zinc By similarity
Metal binding321Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8K9D8 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 38840ED621058DB3

FASTA12014,273
        10         20         30         40         50         60 
MKTIIFKDFQ FEAAHYLPYV PKMHKCRRLH GHSFFVRLEL KDKINEKNGW IIDYAEIKLA 

        70         80         90        100        110        120 
FQPIYDQLDH HFLNDIPGLE NPTSEILAKW IWHRLKPKLS ILNTIIIKET CTSGCIYQGF 

« Hide

References

[1]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE013218 Genomic DNA. Translation: AAM67953.1.
RefSeqNP_660742.1. NC_004061.1.

3D structure databases

ProteinModelPortalQ8K9D8.
SMRQ8K9D8. Positions 5-119.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198804.BUsg402.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM67953; AAM67953; BUsg_402.
GeneID1005758.
KEGGbas:BUsg402.
PATRIC21247630. VBIBucAph100086_0415.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0720.
KOK01737.
OMAWIRDFSE.
OrthoDBEOG6FFSCJ.

Enzyme and pathway databases

BioCycBAPH198804:GHMG-425-MONOMER.
UniPathwayUPA00391.

Family and domain databases

InterProIPR007115. 6-PTP_synth/QueD.
[Graphical view]
PANTHERPTHR12589. PTHR12589. 1 hit.
PfamPF01242. PTPS. 1 hit.
[Graphical view]
PIRSFPIRSF006113. PTP_synth. 1 hit.
TIGRFAMsTIGR03367. queuosine_QueD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQUED_BUCAP
AccessionPrimary (citable) accession number: Q8K9D8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: November 13, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names