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Protein

6-carboxy-5,6,7,8-tetrahydropterin synthase

Gene

queD

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde.By similarity

Miscellaneous

The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit (By similarity).By similarity

Catalytic activityi

7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: 7-cyano-7-deazaguanine biosynthesis

This protein is involved in the pathway 7-cyano-7-deazaguanine biosynthesis, which is part of Purine metabolism.
View all proteins of this organism that are known to be involved in the pathway 7-cyano-7-deazaguanine biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi15ZincBy similarity1
Active sitei26Proton acceptorBy similarity1
Metal bindingi30ZincBy similarity1
Metal bindingi32ZincBy similarity1
Active sitei70Charge relay systemBy similarity1
Active sitei109Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processQueuosine biosynthesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciBAPH198804:G1FZU-426-MONOMER
UniPathwayiUPA00391

Names & Taxonomyi

Protein namesi
Recommended name:
6-carboxy-5,6,7,8-tetrahydropterin synthase (EC:4.1.2.50)
Short name:
CPH4 synthase
Alternative name(s):
Queuosine biosynthesis protein QueD
Gene namesi
Name:queD
Ordered Locus Names:BUsg_402
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000416 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000579211 – 1206-carboxy-5,6,7,8-tetrahydropterin synthaseAdd BLAST120

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg402

Structurei

3D structure databases

ProteinModelPortaliQ8K9D8
SMRiQ8K9D8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTPS family. QueD subfamily.Curated

Phylogenomic databases

eggNOGiENOG4107ZIF Bacteria
COG0720 LUCA
KOiK01737
OMAiKCEKLHG
OrthoDBiPOG091H01RY

Family and domain databases

Gene3Di3.30.479.10, 1 hit
InterProiView protein in InterPro
IPR007115 6-PTP_synth/QueD
IPR038418 6-PTP_synth/QueD_sf
PANTHERiPTHR12589 PTHR12589, 1 hit
PfamiView protein in Pfam
PF01242 PTPS, 1 hit
PIRSFiPIRSF006113 PTP_synth, 1 hit
TIGRFAMsiTIGR03367 queuosine_QueD, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K9D8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTIIFKDFQ FEAAHYLPYV PKMHKCRRLH GHSFFVRLEL KDKINEKNGW
60 70 80 90 100
IIDYAEIKLA FQPIYDQLDH HFLNDIPGLE NPTSEILAKW IWHRLKPKLS
110 120
ILNTIIIKET CTSGCIYQGF
Length:120
Mass (Da):14,273
Last modified:October 1, 2002 - v1
Checksum:i38840ED621058DB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA Translation: AAM67953.1
RefSeqiWP_011053920.1, NC_004061.1

Genome annotation databases

EnsemblBacteriaiAAM67953; AAM67953; BUsg_402
KEGGibas:BUsg_402

Similar proteinsi

Entry informationi

Entry nameiQUED_BUCAP
AccessioniPrimary (citable) accession number: Q8K9D8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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