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Q8K9D8

- QUED_BUCAP

UniProt

Q8K9D8 - QUED_BUCAP

Protein

6-carboxy-5,6,7,8-tetrahydropterin synthase

Gene

queD

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde.By similarity

    Catalytic activityi

    7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi15 – 151ZincBy similarity
    Active sitei26 – 261Proton acceptorBy similarity
    Metal bindingi30 – 301ZincBy similarity
    Metal bindingi32 – 321ZincBy similarity
    Active sitei70 – 701Charge relay systemBy similarity
    Active sitei109 – 1091Charge relay systemBy similarity

    GO - Molecular functioni

    1. lyase activity Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. queuosine biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Queuosine biosynthesis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-425-MONOMER.
    UniPathwayiUPA00391.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-carboxy-5,6,7,8-tetrahydropterin synthase (EC:4.1.2.50)
    Short name:
    CPH4 synthase
    Alternative name(s):
    Queuosine biosynthesis protein QueD
    Gene namesi
    Name:queD
    Ordered Locus Names:BUsg_402
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 1201206-carboxy-5,6,7,8-tetrahydropterin synthasePRO_0000057921Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi198804.BUsg402.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K9D8.
    SMRiQ8K9D8. Positions 5-119.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PTPS family. QueD subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0720.
    KOiK01737.
    OMAiGWVMDFS.
    OrthoDBiEOG6FFSCJ.

    Family and domain databases

    InterProiIPR007115. 6-PTP_synth/QueD.
    [Graphical view]
    PANTHERiPTHR12589. PTHR12589. 1 hit.
    PfamiPF01242. PTPS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006113. PTP_synth. 1 hit.
    TIGRFAMsiTIGR03367. queuosine_QueD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8K9D8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTIIFKDFQ FEAAHYLPYV PKMHKCRRLH GHSFFVRLEL KDKINEKNGW    50
    IIDYAEIKLA FQPIYDQLDH HFLNDIPGLE NPTSEILAKW IWHRLKPKLS 100
    ILNTIIIKET CTSGCIYQGF 120
    Length:120
    Mass (Da):14,273
    Last modified:October 1, 2002 - v1
    Checksum:i38840ED621058DB3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67953.1.
    RefSeqiNP_660742.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67953; AAM67953; BUsg_402.
    GeneIDi1005758.
    KEGGibas:BUsg402.
    PATRICi21247630. VBIBucAph100086_0415.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67953.1 .
    RefSeqi NP_660742.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8K9D8.
    SMRi Q8K9D8. Positions 5-119.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg402.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67953 ; AAM67953 ; BUsg_402 .
    GeneIDi 1005758.
    KEGGi bas:BUsg402.
    PATRICi 21247630. VBIBucAph100086_0415.

    Phylogenomic databases

    eggNOGi COG0720.
    KOi K01737.
    OMAi GWVMDFS.
    OrthoDBi EOG6FFSCJ.

    Enzyme and pathway databases

    UniPathwayi UPA00391 .
    BioCyci BAPH198804:GHMG-425-MONOMER.

    Family and domain databases

    InterProi IPR007115. 6-PTP_synth/QueD.
    [Graphical view ]
    PANTHERi PTHR12589. PTHR12589. 1 hit.
    Pfami PF01242. PTPS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006113. PTP_synth. 1 hit.
    TIGRFAMsi TIGR03367. queuosine_QueD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiQUED_BUCAP
    AccessioniPrimary (citable) accession number: Q8K9D8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit By similarity.By similarity

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3