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Q8K9D8

- QUED_BUCAP

UniProt

Q8K9D8 - QUED_BUCAP

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Protein

6-carboxy-5,6,7,8-tetrahydropterin synthase

Gene
queD, BUsg_402
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde By similarity.

Catalytic activityi

7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi15 – 151Zinc By similarity
Active sitei26 – 261Proton acceptor By similarity
Metal bindingi30 – 301Zinc By similarity
Metal bindingi32 – 321Zinc By similarity
Active sitei70 – 701Charge relay system By similarity
Active sitei109 – 1091Charge relay system By similarity

GO - Molecular functioni

  1. lyase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. queuosine biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Queuosine biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-425-MONOMER.
UniPathwayiUPA00391.

Names & Taxonomyi

Protein namesi
Recommended name:
6-carboxy-5,6,7,8-tetrahydropterin synthase (EC:4.1.2.50)
Short name:
CPH4 synthase
Alternative name(s):
Queuosine biosynthesis protein QueD
Gene namesi
Name:queD
Ordered Locus Names:BUsg_402
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1201206-carboxy-5,6,7,8-tetrahydropterin synthasePRO_0000057921Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg402.

Structurei

3D structure databases

ProteinModelPortaliQ8K9D8.
SMRiQ8K9D8. Positions 5-119.

Family & Domainsi

Sequence similaritiesi

Belongs to the PTPS family. QueD subfamily.

Phylogenomic databases

eggNOGiCOG0720.
KOiK01737.
OMAiGWVMDFS.
OrthoDBiEOG6FFSCJ.

Family and domain databases

InterProiIPR007115. 6-PTP_synth/QueD.
[Graphical view]
PANTHERiPTHR12589. PTHR12589. 1 hit.
PfamiPF01242. PTPS. 1 hit.
[Graphical view]
PIRSFiPIRSF006113. PTP_synth. 1 hit.
TIGRFAMsiTIGR03367. queuosine_QueD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K9D8-1 [UniParc]FASTAAdd to Basket

« Hide

MKTIIFKDFQ FEAAHYLPYV PKMHKCRRLH GHSFFVRLEL KDKINEKNGW    50
IIDYAEIKLA FQPIYDQLDH HFLNDIPGLE NPTSEILAKW IWHRLKPKLS 100
ILNTIIIKET CTSGCIYQGF 120
Length:120
Mass (Da):14,273
Last modified:October 1, 2002 - v1
Checksum:i38840ED621058DB3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67953.1.
RefSeqiNP_660742.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67953; AAM67953; BUsg_402.
GeneIDi1005758.
KEGGibas:BUsg402.
PATRICi21247630. VBIBucAph100086_0415.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67953.1 .
RefSeqi NP_660742.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8K9D8.
SMRi Q8K9D8. Positions 5-119.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg402.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67953 ; AAM67953 ; BUsg_402 .
GeneIDi 1005758.
KEGGi bas:BUsg402.
PATRICi 21247630. VBIBucAph100086_0415.

Phylogenomic databases

eggNOGi COG0720.
KOi K01737.
OMAi GWVMDFS.
OrthoDBi EOG6FFSCJ.

Enzyme and pathway databases

UniPathwayi UPA00391 .
BioCyci BAPH198804:GHMG-425-MONOMER.

Family and domain databases

InterProi IPR007115. 6-PTP_synth/QueD.
[Graphical view ]
PANTHERi PTHR12589. PTHR12589. 1 hit.
Pfami PF01242. PTPS. 1 hit.
[Graphical view ]
PIRSFi PIRSF006113. PTP_synth. 1 hit.
TIGRFAMsi TIGR03367. queuosine_QueD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiQUED_BUCAP
AccessioniPrimary (citable) accession number: Q8K9D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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