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Protein

6-carboxy-5,6,7,8-tetrahydropterin synthase

Gene

queD

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde.By similarity

Catalytic activityi

7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: 7-cyano-7-deazaguanine biosynthesis

This protein is involved in the pathway 7-cyano-7-deazaguanine biosynthesis, which is part of Purine metabolism.
View all proteins of this organism that are known to be involved in the pathway 7-cyano-7-deazaguanine biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi15 – 151ZincBy similarity
Active sitei26 – 261Proton acceptorBy similarity
Metal bindingi30 – 301ZincBy similarity
Metal bindingi32 – 321ZincBy similarity
Active sitei70 – 701Charge relay systemBy similarity
Active sitei109 – 1091Charge relay systemBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Queuosine biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-425-MONOMER.
UniPathwayiUPA00391.

Names & Taxonomyi

Protein namesi
Recommended name:
6-carboxy-5,6,7,8-tetrahydropterin synthase (EC:4.1.2.50)
Short name:
CPH4 synthase
Alternative name(s):
Queuosine biosynthesis protein QueD
Gene namesi
Name:queD
Ordered Locus Names:BUsg_402
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
Proteomesi
  • UP000000416 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1201206-carboxy-5,6,7,8-tetrahydropterin synthasePRO_0000057921Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg402.

Structurei

3D structure databases

ProteinModelPortaliQ8K9D8.
SMRiQ8K9D8. Positions 5-119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTPS family. QueD subfamily.Curated

Phylogenomic databases

eggNOGiENOG4107ZIF. Bacteria.
COG0720. LUCA.
KOiK01737.
OMAiPNVPETH.
OrthoDBiEOG6FFSCJ.

Family and domain databases

InterProiIPR007115. 6-PTP_synth/QueD.
[Graphical view]
PANTHERiPTHR12589. PTHR12589. 1 hit.
PfamiPF01242. PTPS. 1 hit.
[Graphical view]
PIRSFiPIRSF006113. PTP_synth. 1 hit.
TIGRFAMsiTIGR03367. queuosine_QueD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K9D8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTIIFKDFQ FEAAHYLPYV PKMHKCRRLH GHSFFVRLEL KDKINEKNGW
60 70 80 90 100
IIDYAEIKLA FQPIYDQLDH HFLNDIPGLE NPTSEILAKW IWHRLKPKLS
110 120
ILNTIIIKET CTSGCIYQGF
Length:120
Mass (Da):14,273
Last modified:October 1, 2002 - v1
Checksum:i38840ED621058DB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67953.1.
RefSeqiWP_011053920.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67953; AAM67953; BUsg_402.
KEGGibas:BUsg_402.
PATRICi21247630. VBIBucAph100086_0415.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67953.1.
RefSeqiWP_011053920.1. NC_004061.1.

3D structure databases

ProteinModelPortaliQ8K9D8.
SMRiQ8K9D8. Positions 5-119.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198804.BUsg402.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM67953; AAM67953; BUsg_402.
KEGGibas:BUsg_402.
PATRICi21247630. VBIBucAph100086_0415.

Phylogenomic databases

eggNOGiENOG4107ZIF. Bacteria.
COG0720. LUCA.
KOiK01737.
OMAiPNVPETH.
OrthoDBiEOG6FFSCJ.

Enzyme and pathway databases

UniPathwayiUPA00391.
BioCyciBAPH198804:GHMG-425-MONOMER.

Family and domain databases

InterProiIPR007115. 6-PTP_synth/QueD.
[Graphical view]
PANTHERiPTHR12589. PTHR12589. 1 hit.
PfamiPF01242. PTPS. 1 hit.
[Graphical view]
PIRSFiPIRSF006113. PTP_synth. 1 hit.
TIGRFAMsiTIGR03367. queuosine_QueD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiQUED_BUCAP
AccessioniPrimary (citable) accession number: Q8K9D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: November 11, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit (By similarity).By similarity

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.