Q8K9D4 (CYSC_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylyl-sulfate kinase
EC=2.7.1.25

Alternative name(s):
APS kinase
ATP adenosine-5'-phosphosulfate 3'-phosphotransferase
Adenosine-5'-phosphosulfate kinase

Gene names

Name:	cysC
Ordered Locus Names:	BUsg_407

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the synthesis of activated sulfate. HAMAP MF_00065
Catalytic activity	ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate. HAMAP MF_00065
Pathway	Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3. HAMAP MF_00065
Sequence similarities	Belongs to the APS kinase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	sulfate assimilation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylylsulfate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 211	211	Adenylyl-sulfate kinase HAMAP MF_00065		PRO_0000105906
Regions
	Nucleotide binding	36 – 43	8	ATP Potential
Sites
	Active site	110	1	Phosphoserine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8K9D4 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 0644BA855D76B6B1	FASTA	211	24,288
	10 20 30 40 50 60 MHNNSKKNII WQKHSVTRIK REQKNGHKSI VIWFTGLSGS GKSSIANSLE EILFQNNFNT 70 80 90 100 110 120 YLLDGDNIRS SLCSDLSFSI LDRNENIRRI GEVSKLMIDA GIIVLVSVIS PYRNQRKKIR 130 140 150 160 170 180 LMLGKINFLE VFVDTPLNIC EERDPKKLYQ KSRLGKISDL TGIQSLYEIP EKPDLHLDET 190 200 210 ISLKNNTKKL IHILCDKNII SFPNIDETFL F

References

[1]	"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013218 Genomic DNA. Translation: AAM67957.1.
RefSeq	NP_660746.1. NC_004061.1.
3D structure databases
ProteinModelPortal	Q8K9D4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBUCT00000000194; EBBUCP00000000194; EBBUCG00000000194.
GeneID	1005753.
GenomeReviews	Gene locus BUsg_407 in contig AE013218_GR.
KEGG	bas:BUsg407.
PATRIC	21247640. VBIBucAph100086_0420.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000007848.
HOGENOM	HBG309946.
OMA	LAGEIPH.
ProtClustDB	CLSK341926.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG407-MONOMER.
Family and domain databases
HAMAP	MF_00065. Adenylyl_sulf_kinase. [Tree]
InterPro	IPR002891. APS_kinase_C. [Graphical view]
KO	K00860.
Pfam	PF01583. APS_kinase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00455. ApsK. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CYSC_BUCAP

Accession

Primary (citable) accession number: Q8K9D4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program