Reviewed, UniProtKB/Swiss-Prot Q8K9D4 (CYSC_BUCAP)

Names and origin

Protein names

Recommended name:
    Adenylyl-sulfate kinase
    EC=2.7.1.25
Alternative name(s):
    APS kinase
    Adenosine-5'-phosphosulfate kinase
    ATP adenosine-5'-phosphosulfate 3'-phosphotransferase

Gene names

Name:	cysC
Ordered Locus Names:	BUsg_407

Organism

Buchnera aphidicola subsp. Schizaphis graminum [Complete proteome] [HAMAP]

Taxonomic identifier

98794 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the synthesis of activated sulfate. HAMAP MF_00065
Catalytic activity	ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate. HAMAP MF_00065
Pathway	Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3. HAMAP MF_00065
Sequence similarities	Belongs to the APS kinase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	sulfate assimilation Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP adenylylsulfate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 211	211	Adenylyl-sulfate kinase HAMAP MF_00065		PRO_0000105906
Regions
	Nucleotide binding	36 – 43	8	ATP Potential
Sites
	Active site	110	1	Phosphoserine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8K9D4-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 0644BA855D76B6B1	FASTA	211	24,288
	10 20 30 40 50 60 MHNNSKKNII WQKHSVTRIK REQKNGHKSI VIWFTGLSGS GKSSIANSLE EILFQNNFNT 70 80 90 100 110 120 YLLDGDNIRS SLCSDLSFSI LDRNENIRRI GEVSKLMIDA GIIVLVSVIS PYRNQRKKIR 130 140 150 160 170 180 LMLGKINFLE VFVDTPLNIC EERDPKKLYQ KSRLGKISDL TGIQSLYEIP EKPDLHLDET 190 200 210 ISLKNNTKKL IHILCDKNII SFPNIDETFL F

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE013218 Genomic DNA. Translation: AAM67957.1.
RefSeq	NP_660746.1.
3D structure databases
HSSP	HSSP built from PDB template 1M7G based on UniProtKB Q12657.
ModBase	Search...
Genome annotation databases
GeneID	1005753.
GenomeReviews	Gene locus BUsg_407 in contig AE013218_GR.
KEGG	bas:BUsg407.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8K9D4.
OMA	Q8K9D4. IITITAF.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG407-MON.
Family and domain databases
HAMAP	MF_00065. [Tree]
InterPro	IPR002891. APS_kinase_C. [Graphical view]
Pfam	PF01583. APS_kinase. 1 hit. [Graphical view]
ProDom	PD002350. APS_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00455. apsK. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CYSC_BUCAP

Accession

Primary (citable) accession number: Q8K9D4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)