Reviewed, UniProtKB/Swiss-Prot Q8K9C7 (KGUA_BUCAP)

Names and origin

Protein names

Recommended name:
    Guanylate kinase
    EC=2.7.4.8
Alternative name(s):
    GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	BUsg_419

Organism

Buchnera aphidicola subsp. Schizaphis graminum [Complete proteome] [HAMAP]

Taxonomic identifier

98794 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity HAMAP MF_00328.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP guanylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Guanylate kinase HAMAP MF_00328		PRO_0000170511
Regions
	Domain	4 – 184	181	Guanylate kinase-like
	Nucleotide binding	11 – 18	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8K9C7-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 6C68A9D261F32F90	FASTA	207	24,153
	10 20 30 40 50 60 MSQGILFIIS APSGTGKSSL IEGLLKTKFL YNIQVSISHT TRVMRPGESH GKHYYFISKK 70 80 90 100 110 120 EFRIMIKQES FLEYAKVFNN YYGTSRQSIE KMLLSGIDVF LDIDWQGANQ IRYKMPNSKS 130 140 150 160 170 180 IFLLPPSKDE LYKRLRERGQ DSDTVISKRM EKAVDEMNHY SEYDYLIIND DFQKAINDLR 190 200 TIIIAEHLCL FHQKNKHNVL ISQLLKS

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013218 Genomic DNA. Translation: AAM67964.1.
RefSeq	NP_660753.1.
3D structure databases
SMR	Q8K9C7. Positions 2-205.
ModBase	Search...
Genome annotation databases
GeneID	1005742.
GenomeReviews	Gene locus BUsg_419 in contig AE013218_GR.
KEGG	bas:BUsg419.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG671982.
OMA	DIDWQGT.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG419-MONOMER.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_BUCAP

Accession

Primary (citable) accession number: Q8K9C7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2002
Last modified:	February 9, 2010
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)