Q8K9C7 (KGUA_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanylate kinase
EC=2.7.4.8

Alternative name(s):
GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	BUsg_419

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Schizaphis graminum)

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00328.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Guanylate kinase HAMAP-Rule MF_00328		PRO_0000170511
Regions
	Domain	4 – 184	181	Guanylate kinase-like
	Nucleotide binding	11 – 18	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8K9C7 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 6C68A9D261F32F90	FASTA	207	24,153
	10 20 30 40 50 60 MSQGILFIIS APSGTGKSSL IEGLLKTKFL YNIQVSISHT TRVMRPGESH GKHYYFISKK 70 80 90 100 110 120 EFRIMIKQES FLEYAKVFNN YYGTSRQSIE KMLLSGIDVF LDIDWQGANQ IRYKMPNSKS 130 140 150 160 170 180 IFLLPPSKDE LYKRLRERGQ DSDTVISKRM EKAVDEMNHY SEYDYLIIND DFQKAINDLR 190 200 TIIIAEHLCL FHQKNKHNVL ISQLLKS

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013218 Genomic DNA. Translation: AAM67964.1.
RefSeq	NP_660753.1. NC_004061.1.
3D structure databases
ProteinModelPortal	Q8K9C7.
SMR	Q8K9C7. Positions 2-205.
ModBase	Search...
Protein-protein interaction databases
STRING	198804.BUsg419.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM67964; AAM67964; BUsg_419.
GeneID	1005742.
KEGG	bas:BUsg419.
PATRIC	21247682. VBIBucAph100086_0441.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0194.
KO	K00942.
OMA	FVIINEL.
ProtClustDB	PRK00300.
Enzyme and pathway databases
BioCyc	BAPH198804:GHMG-442-MONOMER.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase.
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_BUCAP

Accession

Primary (citable) accession number: Q8K9C7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2002
Last modified:	May 29, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program