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Q8K9B9

- SYL_BUCAP

UniProt

Q8K9B9 - SYL_BUCAP

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei623 – 6231ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-452-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BUsg_429
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 861861Leucine--tRNA ligasePRO_0000151988Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi198804.BUsg429.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K9B9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi620 – 6245"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K9B9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKEYCPKNI EPYVQQYWKD NKVFHVYEDD KKEKYYCLPM LPYPSGKLHM    50
    GHVRNYTISD VISRYQRMLG KNVLQPIGWD AFGLPAEEAA IKNKTKPSDW 100
    TQKNIKYMKK QLQSLGFSYD WSREITTCKP DYYCWEQWFF IQLYKKKLVY 150
    KKNSFVNWCP YDKTVLANEQ VIKGCCWRCQ NKIKVKKIPQ WFIKIRNYAE 200
    SLHNDLNDLE NWPEKVKNMQ RNWIGRSKGF EIVFNVLNSN KKIKAFTNRL 250
    DLIMGATYIS ISPCHEFSVH VSKEKKEIQK FIDQKINNSA SQEDIEKIKF 300
    EGINSNMFVI HPITNKKIPV WISNFIQKEY GTNAIISVPG HNQNDWNFSI 350
    KHNLKIKYVI KNKKYKNTQL HNLFTTEKGI LYNSGEFNNL NYHNATEKIK 400
    KTLLKKKIIK EKINYKLQDW CISRQRYWGT PIPMATKKNG EIIAIPEKNL 450
    PVLLPEIKNY SDSLQKPMDS SSKWANIKIE NQDVIRETDT FDTFMESSWY 500
    YARYTCPNFN TGMIDPTASK YWLPVDQYIG GIEHATMHLI YFRFYHKLLR 550
    DFKLVELNEP VKNLICQGMV LSEAFYQFDK NNQRNWIHPS CVQVEKNLKG 600
    ETIKVDIKNK KKVIYAGMIK MSKSKNNGIE PELMINRYGA DTLRLFIMFA 650
    APIESSLEWR ESGVKGIYRF LKKIWKLVFN HIEVKKINKK VNFDILNKKQ 700
    KKMYCLLHKT IIKVSDDIGR RKSFNTAISS IMELVNELSI FKIENEEDKS 750
    IIKESLMSII KMLYPFTPHF CFRLWQYLNK NCCIDYETWP TFEKKILSSD 800
    KNTLIIQING KKQCAIEVKN HLNKEEILSY IENQSIIQKK IKNLKIIKII 850
    YIPQKVINFV V 861
    Length:861
    Mass (Da):102,107
    Last modified:October 1, 2002 - v1
    Checksum:i3616484C35A366E0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67972.1.
    RefSeqiNP_660761.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67972; AAM67972; BUsg_429.
    GeneIDi1005734.
    KEGGibas:BUsg429.
    PATRICi21247708. VBIBucAph100086_0454.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67972.1 .
    RefSeqi NP_660761.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8K9B9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg429.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67972 ; AAM67972 ; BUsg_429 .
    GeneIDi 1005734.
    KEGGi bas:BUsg429.
    PATRICi 21247708. VBIBucAph100086_0454.

    Phylogenomic databases

    eggNOGi COG0495.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BAPH198804:GHMG-452-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiSYL_BUCAP
    AccessioniPrimary (citable) accession number: Q8K9B9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3