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Q8K9B9

- SYL_BUCAP

UniProt

Q8K9B9 - SYL_BUCAP

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei623 – 6231ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-452-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:BUsg_429
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 861861Leucine--tRNA ligasePRO_0000151988Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg429.

Structurei

3D structure databases

ProteinModelPortaliQ8K9B9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi620 – 6245"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K9B9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKEYCPKNI EPYVQQYWKD NKVFHVYEDD KKEKYYCLPM LPYPSGKLHM
60 70 80 90 100
GHVRNYTISD VISRYQRMLG KNVLQPIGWD AFGLPAEEAA IKNKTKPSDW
110 120 130 140 150
TQKNIKYMKK QLQSLGFSYD WSREITTCKP DYYCWEQWFF IQLYKKKLVY
160 170 180 190 200
KKNSFVNWCP YDKTVLANEQ VIKGCCWRCQ NKIKVKKIPQ WFIKIRNYAE
210 220 230 240 250
SLHNDLNDLE NWPEKVKNMQ RNWIGRSKGF EIVFNVLNSN KKIKAFTNRL
260 270 280 290 300
DLIMGATYIS ISPCHEFSVH VSKEKKEIQK FIDQKINNSA SQEDIEKIKF
310 320 330 340 350
EGINSNMFVI HPITNKKIPV WISNFIQKEY GTNAIISVPG HNQNDWNFSI
360 370 380 390 400
KHNLKIKYVI KNKKYKNTQL HNLFTTEKGI LYNSGEFNNL NYHNATEKIK
410 420 430 440 450
KTLLKKKIIK EKINYKLQDW CISRQRYWGT PIPMATKKNG EIIAIPEKNL
460 470 480 490 500
PVLLPEIKNY SDSLQKPMDS SSKWANIKIE NQDVIRETDT FDTFMESSWY
510 520 530 540 550
YARYTCPNFN TGMIDPTASK YWLPVDQYIG GIEHATMHLI YFRFYHKLLR
560 570 580 590 600
DFKLVELNEP VKNLICQGMV LSEAFYQFDK NNQRNWIHPS CVQVEKNLKG
610 620 630 640 650
ETIKVDIKNK KKVIYAGMIK MSKSKNNGIE PELMINRYGA DTLRLFIMFA
660 670 680 690 700
APIESSLEWR ESGVKGIYRF LKKIWKLVFN HIEVKKINKK VNFDILNKKQ
710 720 730 740 750
KKMYCLLHKT IIKVSDDIGR RKSFNTAISS IMELVNELSI FKIENEEDKS
760 770 780 790 800
IIKESLMSII KMLYPFTPHF CFRLWQYLNK NCCIDYETWP TFEKKILSSD
810 820 830 840 850
KNTLIIQING KKQCAIEVKN HLNKEEILSY IENQSIIQKK IKNLKIIKII
860
YIPQKVINFV V
Length:861
Mass (Da):102,107
Last modified:October 1, 2002 - v1
Checksum:i3616484C35A366E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67972.1.
RefSeqiNP_660761.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67972; AAM67972; BUsg_429.
GeneIDi1005734.
KEGGibas:BUsg429.
PATRICi21247708. VBIBucAph100086_0454.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM67972.1 .
RefSeqi NP_660761.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8K9B9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg429.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67972 ; AAM67972 ; BUsg_429 .
GeneIDi 1005734.
KEGGi bas:BUsg429.
PATRICi 21247708. VBIBucAph100086_0454.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BAPH198804:GHMG-452-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiSYL_BUCAP
AccessioniPrimary (citable) accession number: Q8K9B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3