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Q8K9B9

- SYL_BUCAP

UniProt

Q8K9B9 - SYL_BUCAP

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Protein
Leucine--tRNA ligase
Gene
leuS, BUsg_429
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei623 – 6231ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-452-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:BUsg_429
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 861861Leucine--tRNA ligaseUniRule annotation
PRO_0000151988Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg429.

Structurei

3D structure databases

ProteinModelPortaliQ8K9B9.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi620 – 6245"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K9B9-1 [UniParc]FASTAAdd to Basket

« Hide

MEKEYCPKNI EPYVQQYWKD NKVFHVYEDD KKEKYYCLPM LPYPSGKLHM    50
GHVRNYTISD VISRYQRMLG KNVLQPIGWD AFGLPAEEAA IKNKTKPSDW 100
TQKNIKYMKK QLQSLGFSYD WSREITTCKP DYYCWEQWFF IQLYKKKLVY 150
KKNSFVNWCP YDKTVLANEQ VIKGCCWRCQ NKIKVKKIPQ WFIKIRNYAE 200
SLHNDLNDLE NWPEKVKNMQ RNWIGRSKGF EIVFNVLNSN KKIKAFTNRL 250
DLIMGATYIS ISPCHEFSVH VSKEKKEIQK FIDQKINNSA SQEDIEKIKF 300
EGINSNMFVI HPITNKKIPV WISNFIQKEY GTNAIISVPG HNQNDWNFSI 350
KHNLKIKYVI KNKKYKNTQL HNLFTTEKGI LYNSGEFNNL NYHNATEKIK 400
KTLLKKKIIK EKINYKLQDW CISRQRYWGT PIPMATKKNG EIIAIPEKNL 450
PVLLPEIKNY SDSLQKPMDS SSKWANIKIE NQDVIRETDT FDTFMESSWY 500
YARYTCPNFN TGMIDPTASK YWLPVDQYIG GIEHATMHLI YFRFYHKLLR 550
DFKLVELNEP VKNLICQGMV LSEAFYQFDK NNQRNWIHPS CVQVEKNLKG 600
ETIKVDIKNK KKVIYAGMIK MSKSKNNGIE PELMINRYGA DTLRLFIMFA 650
APIESSLEWR ESGVKGIYRF LKKIWKLVFN HIEVKKINKK VNFDILNKKQ 700
KKMYCLLHKT IIKVSDDIGR RKSFNTAISS IMELVNELSI FKIENEEDKS 750
IIKESLMSII KMLYPFTPHF CFRLWQYLNK NCCIDYETWP TFEKKILSSD 800
KNTLIIQING KKQCAIEVKN HLNKEEILSY IENQSIIQKK IKNLKIIKII 850
YIPQKVINFV V 861
Length:861
Mass (Da):102,107
Last modified:October 1, 2002 - v1
Checksum:i3616484C35A366E0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67972.1.
RefSeqiNP_660761.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67972; AAM67972; BUsg_429.
GeneIDi1005734.
KEGGibas:BUsg429.
PATRICi21247708. VBIBucAph100086_0454.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67972.1 .
RefSeqi NP_660761.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8K9B9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 198804.BUsg429.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67972 ; AAM67972 ; BUsg_429 .
GeneIDi 1005734.
KEGGi bas:BUsg429.
PATRICi 21247708. VBIBucAph100086_0454.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BAPH198804:GHMG-452-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiSYL_BUCAP
AccessioniPrimary (citable) accession number: Q8K9B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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