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Q8K9B8

- HOLA_BUCAP

UniProt

Q8K9B8 - HOLA_BUCAP

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Protein

DNA polymerase III subunit delta

Gene
holA, BUsg_430
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA By similarity.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-453-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase III subunit delta (EC:2.7.7.7)
Gene namesi
Name:holA
Ordered Locus Names:BUsg_430
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. DNA polymerase III complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338DNA polymerase III subunit deltaPRO_0000105503Add
BLAST

Interactioni

Subunit structurei

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex By similarity.

Protein-protein interaction databases

STRINGi198804.BUsg430.

Structurei

3D structure databases

ProteinModelPortaliQ8K9B8.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1466.
KOiK02340.
OMAiNHWIESI.
OrthoDBiEOG6BCSPJ.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR008921. DNA_pol3_clamp-load_cplx_C.
IPR010372. DNA_pol3_delta.
IPR005790. DNA_polIII_delta.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF06144. DNA_pol3_delta. 1 hit.
[Graphical view]
SUPFAMiSSF48019. SSF48019. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01128. holA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K9B8-1 [UniParc]FASTAAdd to Basket

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MKIIYPEELK QKLIKKLNYF YILLGEDSIL LSKAEQLIFY FAKDKKFIEK    50
NTINIEKSTD WNKVINFHKS KNLFFKKTIL IINFTIKKLN LSLVKNINKI 100
PLFKNKDILT VIKLNALSSL IKKSTILKIL ILESEIIYCS TPYEWAFKKW 150
LQYEIKTRNL KITQESFLLL HKYYEGNTLC LNQILDILSI TWPNENIKIE 200
KIKKIINQFS IFSPVNWINA IFNKNKKKAI YILDSFFKQK YNPLILIRTL 250
QKDLLILLNM KREKKLNINF FLKKNNISLN RSKFFANALY YIDFNNFLKI 300
IRILLQIEIK IKKEYNNSVW IQLKTLTLLL SSPMKYTP 338
Length:338
Mass (Da):40,430
Last modified:October 1, 2002 - v1
Checksum:i600B449B547721B3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67973.1.
RefSeqiNP_660762.1. NC_004061.1.
WP_011053940.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67973; AAM67973; BUsg_430.
GeneIDi1005733.
KEGGibas:BUsg430.
PATRICi21247710. VBIBucAph100086_0455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67973.1 .
RefSeqi NP_660762.1. NC_004061.1.
WP_011053940.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8K9B8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg430.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67973 ; AAM67973 ; BUsg_430 .
GeneIDi 1005733.
KEGGi bas:BUsg430.
PATRICi 21247710. VBIBucAph100086_0455.

Phylogenomic databases

eggNOGi COG1466.
KOi K02340.
OMAi NHWIESI.
OrthoDBi EOG6BCSPJ.

Enzyme and pathway databases

BioCyci BAPH198804:GHMG-453-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR008921. DNA_pol3_clamp-load_cplx_C.
IPR010372. DNA_pol3_delta.
IPR005790. DNA_polIII_delta.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF06144. DNA_pol3_delta. 1 hit.
[Graphical view ]
SUPFAMi SSF48019. SSF48019. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR01128. holA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiHOLA_BUCAP
AccessioniPrimary (citable) accession number: Q8K9B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names

External Data

Dasty 3

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