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Q8K9B8 (HOLA_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA polymerase III subunit delta

EC=2.7.7.7
Gene names
Name:holA
Ordered Locus Names:BUsg_430
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA By similarity.

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Subunit structure

DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex By similarity.

Ontologies

Keywords
   Biological processDNA replication
   Molecular functionDNA-directed DNA polymerase
Nucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentDNA polymerase III complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: InterPro

DNA-directed DNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338DNA polymerase III subunit delta
PRO_0000105503

Sequences

Sequence LengthMass (Da)Tools
Q8K9B8 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 600B449B547721B3

FASTA33840,430
        10         20         30         40         50         60 
MKIIYPEELK QKLIKKLNYF YILLGEDSIL LSKAEQLIFY FAKDKKFIEK NTINIEKSTD 

        70         80         90        100        110        120 
WNKVINFHKS KNLFFKKTIL IINFTIKKLN LSLVKNINKI PLFKNKDILT VIKLNALSSL 

       130        140        150        160        170        180 
IKKSTILKIL ILESEIIYCS TPYEWAFKKW LQYEIKTRNL KITQESFLLL HKYYEGNTLC 

       190        200        210        220        230        240 
LNQILDILSI TWPNENIKIE KIKKIINQFS IFSPVNWINA IFNKNKKKAI YILDSFFKQK 

       250        260        270        280        290        300 
YNPLILIRTL QKDLLILLNM KREKKLNINF FLKKNNISLN RSKFFANALY YIDFNNFLKI 

       310        320        330 
IRILLQIEIK IKKEYNNSVW IQLKTLTLLL SSPMKYTP 

« Hide

References

[1]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE013218 Genomic DNA. Translation: AAM67973.1.
RefSeqNP_660762.1. NC_004061.1.

3D structure databases

ProteinModelPortalQ8K9B8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198804.BUsg430.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM67973; AAM67973; BUsg_430.
GeneID1005733.
KEGGbas:BUsg430.
PATRIC21247710. VBIBucAph100086_0455.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1466.
KOK02340.
OMANHWIESI.
OrthoDBEOG6BCSPJ.
ProtClustDBCLSK316213.

Enzyme and pathway databases

BioCycBAPH198804:GHMG-453-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR008921. DNA_pol3_clamp-load_cplx_C.
IPR010372. DNA_pol3_delta.
IPR005790. DNA_polIII_delta.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF06144. DNA_pol3_delta. 1 hit.
[Graphical view]
SUPFAMSSF48019. SSF48019. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR01128. holA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHOLA_BUCAP
AccessionPrimary (citable) accession number: Q8K9B8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names