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Q8K9B8

- HOLA_BUCAP

UniProt

Q8K9B8 - HOLA_BUCAP

Protein

DNA polymerase III subunit delta

Gene

holA

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA By similarity.By similarity

    Catalytic activityi

    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. DNA-directed DNA polymerase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-453-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymerase III subunit delta (EC:2.7.7.7)
    Gene namesi
    Name:holA
    Ordered Locus Names:BUsg_430
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. DNA polymerase III complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 338338DNA polymerase III subunit deltaPRO_0000105503Add
    BLAST

    Interactioni

    Subunit structurei

    DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex By similarity.By similarity

    Protein-protein interaction databases

    STRINGi198804.BUsg430.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K9B8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG1466.
    KOiK02340.
    OMAiNHWIESI.
    OrthoDBiEOG6BCSPJ.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR008921. DNA_pol3_clamp-load_cplx_C.
    IPR010372. DNA_pol3_delta.
    IPR005790. DNA_polIII_delta.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF06144. DNA_pol3_delta. 1 hit.
    [Graphical view]
    SUPFAMiSSF48019. SSF48019. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01128. holA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8K9B8-1 [UniParc]FASTAAdd to Basket

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    MKIIYPEELK QKLIKKLNYF YILLGEDSIL LSKAEQLIFY FAKDKKFIEK    50
    NTINIEKSTD WNKVINFHKS KNLFFKKTIL IINFTIKKLN LSLVKNINKI 100
    PLFKNKDILT VIKLNALSSL IKKSTILKIL ILESEIIYCS TPYEWAFKKW 150
    LQYEIKTRNL KITQESFLLL HKYYEGNTLC LNQILDILSI TWPNENIKIE 200
    KIKKIINQFS IFSPVNWINA IFNKNKKKAI YILDSFFKQK YNPLILIRTL 250
    QKDLLILLNM KREKKLNINF FLKKNNISLN RSKFFANALY YIDFNNFLKI 300
    IRILLQIEIK IKKEYNNSVW IQLKTLTLLL SSPMKYTP 338
    Length:338
    Mass (Da):40,430
    Last modified:October 1, 2002 - v1
    Checksum:i600B449B547721B3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67973.1.
    RefSeqiNP_660762.1. NC_004061.1.
    WP_011053940.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67973; AAM67973; BUsg_430.
    GeneIDi1005733.
    KEGGibas:BUsg430.
    PATRICi21247710. VBIBucAph100086_0455.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67973.1 .
    RefSeqi NP_660762.1. NC_004061.1.
    WP_011053940.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8K9B8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg430.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67973 ; AAM67973 ; BUsg_430 .
    GeneIDi 1005733.
    KEGGi bas:BUsg430.
    PATRICi 21247710. VBIBucAph100086_0455.

    Phylogenomic databases

    eggNOGi COG1466.
    KOi K02340.
    OMAi NHWIESI.
    OrthoDBi EOG6BCSPJ.

    Enzyme and pathway databases

    BioCyci BAPH198804:GHMG-453-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR008921. DNA_pol3_clamp-load_cplx_C.
    IPR010372. DNA_pol3_delta.
    IPR005790. DNA_polIII_delta.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF06144. DNA_pol3_delta. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48019. SSF48019. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01128. holA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiHOLA_BUCAP
    AccessioniPrimary (citable) accession number: Q8K9B8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names

    External Data

    Dasty 3