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Q8K9B7 (NADD_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable nicotinate-nucleotide adenylyltransferase

EC=2.7.7.18
Alternative name(s):
Deamido-NAD(+) diphosphorylase
Deamido-NAD(+) pyrophosphorylase
Nicotinate mononucleotide adenylyltransferase
Short name=NaMN adenylyltransferase
Gene names
Name:nadD
Ordered Locus Names:BUsg_431
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) By similarity. HAMAP-Rule MF_00244

Catalytic activity

ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+. HAMAP-Rule MF_00244

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. HAMAP-Rule MF_00244

Sequence similarities

Belongs to the NadD family.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   LigandATP-binding
NAD
Nucleotide-binding
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

nicotinate-nucleotide adenylyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 216216Probable nicotinate-nucleotide adenylyltransferase HAMAP-Rule MF_00244
PRO_0000181399

Sequences

Sequence LengthMass (Da)Tools
Q8K9B7 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 74AE504B3F7F5CE6

FASTA21625,218
        10         20         30         40         50         60 
MKEIYAIFGG NFDPIHYGHI TSAEKLSREI SIKKIILLPN YGPPHRSKTK TSIIDRLKMI 

        70         80         90        100        110        120 
KFAIKDNKLF TISYLETKKN TTFYTIETLK KIRKKIGYLQ PLCFIIGEDN LNNLNIWKDW 

       130        140        150        160        170        180 
KKILSLSHLL ICPRIHIKKS NPKLKKWISD HTTKNSNLLH KKPFGFIFFS KMSMLNISST 

       190        200        210 
AIRKSYYEGK SACGLLPSKI DKYILSKNLY KIYNQN 

« Hide

References

[1]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE013218 Genomic DNA. Translation: AAM67974.1.
RefSeqNP_660763.1. NC_004061.1.

3D structure databases

ProteinModelPortalQ8K9B7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198804.BUsg431.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM67974; AAM67974; BUsg_431.
GeneID1005732.
KEGGbas:BUsg431.
PATRIC21247712. VBIBucAph100086_0456.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1057.
KOK00969.
OMAIQCAPAG.
OrthoDBEOG6F55KJ.
ProtClustDBCLSK316217.

Enzyme and pathway databases

BioCycBAPH198804:GHMG-454-MONOMER.
UniPathwayUPA00253; UER00332.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00244. NaMN_adenylyltr.
InterProIPR004821. Cyt_trans-like.
IPR005248. NAMN_adtrnsfrase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR12039. PTHR12039. 1 hit.
PfamPF01467. CTP_transf_2. 1 hit.
[Graphical view]
TIGRFAMsTIGR00125. cyt_tran_rel. 1 hit.
TIGR00482. TIGR00482. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADD_BUCAP
AccessionPrimary (citable) accession number: Q8K9B7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: February 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names