Q8K9B7 (NADD_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable nicotinate-nucleotide adenylyltransferase
EC=2.7.7.18

Alternative name(s):
Deamido-NAD(+) diphosphorylase
Deamido-NAD(+) pyrophosphorylase
Nicotinate mononucleotide adenylyltransferase
Short name=NaMN adenylyltransferase

Gene names

Name:	nadD
Ordered Locus Names:	BUsg_431

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Schizaphis graminum)

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) By similarity. HAMAP-Rule MF_00244
Catalytic activity	ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+. HAMAP-Rule MF_00244
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. HAMAP-Rule MF_00244
Sequence similarities	Belongs to the NadD family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Ligand	ATP-binding NAD Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nicotinate-nucleotide adenylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 216	216	Probable nicotinate-nucleotide adenylyltransferase HAMAP-Rule MF_00244		PRO_0000181399

Sequences

	Sequence		Length	Mass (Da)
	Q8K9B7 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 74AE504B3F7F5CE6	FASTA	216	25,218
	10 20 30 40 50 60 MKEIYAIFGG NFDPIHYGHI TSAEKLSREI SIKKIILLPN YGPPHRSKTK TSIIDRLKMI 70 80 90 100 110 120 KFAIKDNKLF TISYLETKKN TTFYTIETLK KIRKKIGYLQ PLCFIIGEDN LNNLNIWKDW 130 140 150 160 170 180 KKILSLSHLL ICPRIHIKKS NPKLKKWISD HTTKNSNLLH KKPFGFIFFS KMSMLNISST 190 200 210 AIRKSYYEGK SACGLLPSKI DKYILSKNLY KIYNQN

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013218 Genomic DNA. Translation: AAM67974.1.
RefSeq	NP_660763.1. NC_004061.1.
3D structure databases
ProteinModelPortal	Q8K9B7.
ModBase	Search...
Protein-protein interaction databases
STRING	198804.BUsg431.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM67974; AAM67974; BUsg_431.
GeneID	1005732.
KEGG	bas:BUsg431.
PATRIC	21247712. VBIBucAph100086_0456.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1057.
KO	K00969.
OMA	IQCAPAG.
ProtClustDB	CLSK316217.
Enzyme and pathway databases
BioCyc	BAPH198804:GHMG-476-MONOMER.
UniPathway	UPA00253; UER00332.
Family and domain databases
Gene3D	3.40.50.620. 1 hit.
HAMAP	MF_00244. NaMN_adenylyltr.
InterPro	IPR004821. Cyt_trans-like. IPR005248. NAMN_adtrnsfrase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
PANTHER	PTHR12039. PTHR12039. 1 hit.
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00125. cyt_tran_rel. 1 hit. TIGR00482. TIGR00482. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NADD_BUCAP

Accession

Primary (citable) accession number: Q8K9B7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program