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Q8K9B5

- DHAS_BUCAP

UniProt

Q8K9B5 - DHAS_BUCAP

Protein

Aspartate-semialdehyde dehydrogenase

Gene

asd

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.UniRule annotation

    Catalytic activityi

    L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei75 – 751NADPUniRule annotation
    Binding sitei104 – 1041PhosphateUniRule annotation
    Active sitei137 – 1371Acyl-thioester intermediateUniRule annotation
    Binding sitei164 – 1641SubstrateUniRule annotation
    Binding sitei243 – 2431SubstrateUniRule annotation
    Binding sitei246 – 2461PhosphateUniRule annotation
    Binding sitei269 – 2691SubstrateUniRule annotation
    Active sitei276 – 2761Proton acceptorUniRule annotation
    Binding sitei352 – 3521NADPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 144NADPUniRule annotation
    Nucleotide bindingi38 – 392NADPUniRule annotation
    Nucleotide bindingi167 – 1682NADPUniRule annotation

    GO - Molecular functioni

    1. aspartate-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. N-acetyl-gamma-glutamyl-phosphate reductase activity Source: InterPro
    3. NAD binding Source: InterPro
    4. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' L-methionine biosynthetic process Source: UniProtKB-HAMAP
    2. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
    3. isoleucine biosynthetic process Source: InterPro
    4. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
    5. threonine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis, Methionine biosynthesis, Threonine biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-456-MONOMER.
    UniPathwayiUPA00034; UER00016.
    UPA00050; UER00463.
    UPA00051; UER00464.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartate-semialdehyde dehydrogenaseUniRule annotation (EC:1.2.1.11UniRule annotation)
    Short name:
    ASA dehydrogenaseUniRule annotation
    Short name:
    ASADHUniRule annotation
    Alternative name(s):
    Aspartate-beta-semialdehyde dehydrogenaseUniRule annotation
    Gene namesi
    Name:asdUniRule annotation
    Ordered Locus Names:BUsg_433
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 371371Aspartate-semialdehyde dehydrogenasePRO_0000141364Add
    BLAST

    Proteomic databases

    PRIDEiQ8K9B5.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi198804.BUsg433.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K9B5.
    SMRiQ8K9B5. Positions 3-368.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aspartate-semialdehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0136.
    KOiK00133.
    OMAiLASHNEW.
    OrthoDBiEOG67X1PS.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_02121. ASADH.
    InterProiIPR000319. Asp-semialdehyde_DH_CS.
    IPR011534. Asp_ADH_gamma-type.
    IPR012080. Asp_semialdehyde_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    IPR012280. Semialdhyde_DH_dimer_dom.
    [Graphical view]
    PfamiPF01118. Semialdhyde_dh. 1 hit.
    PF02774. Semialdhyde_dhC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000148. ASA_dh. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01745. asd_gamma. 1 hit.
    PROSITEiPS01103. ASD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K9B5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKSVGIIGW RGMVGSVLLK RMQEENDFSK IIPYFFSTSQ SGQDGPIINN    50
    ILSKNLKDAY NINLLQEMDI IITCQGSSYT EKIYPKLRNN NWQGYWIDAA 100
    STLRMEKDAT IILDPVNLNV INNALDKGIK TFVGGNCTVS LMLMALGGLF 150
    VNNLIDWVFV STYQAASGAG SRYVIELLKQ MGSLYNVVSK DLLDKSYSVL 200
    DIEKKVTQES RSKNFPLENF SVPLATSLIP WIDVEMKNGQ SREEWKGQAE 250
    TNKILNLKKK VLIDGTCVRI SSIRCHSQSF LIKLNKDISL ENIKKIIVNH 300
    NQWVDVIPNN MQKTLCNLTP SAVTDTLNIP IGRLRKLNID DRYLSAFTVG 350
    DQLLWGAAEP LRRMLNLLVN I 371
    Length:371
    Mass (Da):41,785
    Last modified:October 1, 2002 - v1
    Checksum:i079A0E1BEAE68318
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67976.1.
    RefSeqiNP_660765.1. NC_004061.1.
    WP_011053943.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67976; AAM67976; BUsg_433.
    GeneIDi1005553.
    KEGGibas:BUsg433.
    PATRICi21247716. VBIBucAph100086_0458.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67976.1 .
    RefSeqi NP_660765.1. NC_004061.1.
    WP_011053943.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8K9B5.
    SMRi Q8K9B5. Positions 3-368.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg433.

    Proteomic databases

    PRIDEi Q8K9B5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67976 ; AAM67976 ; BUsg_433 .
    GeneIDi 1005553.
    KEGGi bas:BUsg433.
    PATRICi 21247716. VBIBucAph100086_0458.

    Phylogenomic databases

    eggNOGi COG0136.
    KOi K00133.
    OMAi LASHNEW.
    OrthoDBi EOG67X1PS.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00016 .
    UPA00050 ; UER00463 .
    UPA00051 ; UER00464 .
    BioCyci BAPH198804:GHMG-456-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_02121. ASADH.
    InterProi IPR000319. Asp-semialdehyde_DH_CS.
    IPR011534. Asp_ADH_gamma-type.
    IPR012080. Asp_semialdehyde_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    IPR012280. Semialdhyde_DH_dimer_dom.
    [Graphical view ]
    Pfami PF01118. Semialdhyde_dh. 1 hit.
    PF02774. Semialdhyde_dhC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000148. ASA_dh. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01745. asd_gamma. 1 hit.
    PROSITEi PS01103. ASD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiDHAS_BUCAP
    AccessioniPrimary (citable) accession number: Q8K9B5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3