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Q8K9B2

- ALF_BUCAP

UniProt

Q8K9B2 - ALF_BUCAP

Protein

Fructose-bisphosphate aldolase class 2

Gene

fbaA

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Cofactori

    Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei61 – 611Glyceraldehyde 3-phosphateBy similarity
    Active sitei110 – 1101Proton donorBy similarity
    Metal bindingi111 – 1111Zinc 1; catalyticBy similarity
    Metal bindingi145 – 1451Zinc 2By similarity
    Metal bindingi175 – 1751Zinc 2By similarity
    Metal bindingi227 – 2271Zinc 1; catalyticBy similarity
    Binding sitei228 – 2281Dihydroxyacetone phosphate; via amide nitrogenBy similarity
    Metal bindingi265 – 2651Zinc 1; catalyticBy similarity

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-459-MONOMER.
    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase class 2 (EC:4.1.2.13)
    Short name:
    FBP aldolase
    Short name:
    FBPA
    Alternative name(s):
    Fructose-1,6-bisphosphate aldolase
    Fructose-bisphosphate aldolase class II
    Gene namesi
    Name:fbaA
    Synonyms:fba
    Ordered Locus Names:BUsg_436
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Fructose-bisphosphate aldolase class 2PRO_0000178709Add
    BLAST

    Proteomic databases

    PRIDEiQ8K9B2.

    Interactioni

    Protein-protein interaction databases

    STRINGi198804.BUsg436.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K9B2.
    SMRiQ8K9B2. Positions 2-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni266 – 2683Dihydroxyacetone phosphate bindingBy similarity
    Regioni287 – 2904Dihydroxyacetone phosphate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0191.
    KOiK01624.
    OMAiHNSLDFV.
    OrthoDBiEOG69GZPB.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR006411. Fruct_bisP_bact.
    IPR000771. Ketose_bisP_aldolase_II.
    [Graphical view]
    PfamiPF01116. F_bP_aldolase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
    TIGRFAMsiTIGR00167. cbbA. 1 hit.
    TIGR01520. FruBisAldo_II_A. 1 hit.
    PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
    PS00806. ALDOLASE_CLASS_II_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K9B2-1 [UniParc]FASTAAdd to Basket

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    MKILNLIQPG VVTGNECQII FELAKKKKFA IPAVNCIGTD SINAVLETAS    50
    RVKSPVIIQF SYGGASFIAG YKRTSSKNPE DQAIQGSISG AQHVHLMSQY 100
    YQIPVILHTD HCSKEMLPWI DGLLEEGKKH YKNFGKPLFT SHMIDLSKEH 150
    LKENIAICSN YLKKIKKINM ILEIELGCTG GEEDGIDNSN IDKKLLYTQP 200
    KDVNYAYKKL SKISTNFTIA ASFGNVHGVY QPGNVNLKPN ILKESQEYVS 250
    TKHNLKKLPL NLVFHGGSGS DLKEIHESIE YGIVKMNIDT DIQWASWKGV 300
    FNFYKKNKDF LQKQIGNKNG KNIPNKKYYD PRSWIRESQE SMSKRLEKTF 350
    KDLNAFNIL 359
    Length:359
    Mass (Da):40,638
    Last modified:October 1, 2002 - v1
    Checksum:iF1886D3D05238676
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67979.1.
    RefSeqiNP_660768.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67979; AAM67979; BUsg_436.
    GeneIDi1005729.
    KEGGibas:BUsg436.
    PATRICi21247722. VBIBucAph100086_0461.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67979.1 .
    RefSeqi NP_660768.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8K9B2.
    SMRi Q8K9B2. Positions 2-359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg436.

    Proteomic databases

    PRIDEi Q8K9B2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67979 ; AAM67979 ; BUsg_436 .
    GeneIDi 1005729.
    KEGGi bas:BUsg436.
    PATRICi 21247722. VBIBucAph100086_0461.

    Phylogenomic databases

    eggNOGi COG0191.
    KOi K01624.
    OMAi HNSLDFV.
    OrthoDBi EOG69GZPB.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .
    BioCyci BAPH198804:GHMG-459-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR006411. Fruct_bisP_bact.
    IPR000771. Ketose_bisP_aldolase_II.
    [Graphical view ]
    Pfami PF01116. F_bP_aldolase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
    TIGRFAMsi TIGR00167. cbbA. 1 hit.
    TIGR01520. FruBisAldo_II_A. 1 hit.
    PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
    PS00806. ALDOLASE_CLASS_II_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiALF_BUCAP
    AccessioniPrimary (citable) accession number: Q8K9B2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3