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Q8K9A7 (MLTA_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Membrane-bound lytic murein transglycosylase A homolog

EC=4.2.2.n1
Alternative name(s):
Murein hydrolase A
Gene names
Name:mltA
Ordered Locus Names:BUsg_442
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division By similarity.

Catalytic activity

Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.

Subcellular location

Note: In closely related bacteria this protein is attached to the outer membrane by a lipid anchor. This is apparently not the case here.

Ontologies

Keywords
   Biological processCell wall biogenesis/degradation
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpeptidoglycan turnover

Inferred from electronic annotation. Source: InterPro

   Cellular_componentouter membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncarbon-oxygen lyase activity, acting on polysaccharides

Inferred from electronic annotation. Source: UniProtKB-EC

hydrolase activity, hydrolyzing O-glycosyl compounds

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 366366Membrane-bound lytic murein transglycosylase A homolog
PRO_0000196567

Sequences

Sequence LengthMass (Da)Tools
Q8K9A7 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: A07DCD520E5EAB72

FASTA36642,545
        10         20         30         40         50         60 
MLNSCINKIK KKKNIKKIIL MLIFIFSVNF FTKNTNQGKQ YEDKLNKDFT NIKKINIKNK 

        70         80         90        100        110        120 
LVNQKEFLLQ LEKIKIFSPN LYSKNISIYN AILKWLKKRA EINELNKFRI KLFQMKGVDQ 

       130        140        150        160        170        180 
YGNVKITGYY TPIVKASKIK KNNFIYPIYR TPSNFKKNEK LPQRKDIYNG FLKKEYILAY 

       190        200        210        220        230        240 
SDSLINNFIM EIQGSGFIDY GDNKPLIFFG YAKKNNWPYT SIGQILIKNG DIQKKNISMN 

       250        260        270        280        290        300 
TIKNWCTHHT QKEIQNLLEK NKSFVFFQET KRKEVYGSSA VPLVEKAAIA VDKSVIKIGS 

       310        320        330        340        350        360 
VVLVKIPVLD KNGIFIHKYE MHLLIALDVG GVIKGQHFDV YQGIGEKAGK LAGFYNHYGY 


AWVLKI 

« Hide

References

[1]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE013218 Genomic DNA. Translation: AAM67985.1.
RefSeqNP_660774.1. NC_004061.1.

3D structure databases

ProteinModelPortalQ8K9A7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198804.BUsg442.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM67985; AAM67985; BUsg_442.
GeneID1005722.
KEGGbas:BUsg442.
PATRIC21247736. VBIBucAph100086_0467.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2821.
KOK08304.
OMAKREDMSM.
OrthoDBEOG6D2KR5.

Enzyme and pathway databases

BioCycBAPH198804:GHMG-466-MONOMER.

Family and domain databases

Gene3D2.40.40.10. 2 hits.
InterProIPR010611. 3D_dom.
IPR014733. Barwin-like_endoglucanase.
IPR005300. Lytic_transglycosylase_MltA.
IPR026044. MltA.
IPR009009. RlpA-like_DPBB.
[Graphical view]
PfamPF06725. 3D. 1 hit.
PF03562. MltA. 1 hit.
[Graphical view]
PIRSFPIRSF019422. MltA. 1 hit.
SMARTSM00925. MltA. 1 hit.
[Graphical view]
SUPFAMSSF50685. SSF50685. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMLTA_BUCAP
AccessionPrimary (citable) accession number: Q8K9A7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names