Q8K9A7 (MLTA_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Membrane-bound lytic murein transglycosylase A homolog
EC=4.2.2.n1

Alternative name(s):
Murein hydrolase A

Gene names

Name:	mltA
Ordered Locus Names:	BUsg_442

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Schizaphis graminum)

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division By similarity.
Catalytic activity	Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.
Subcellular location	Note: In closely related bacteria this protein is attached to the outer membrane by a lipid anchor. This is apparently not the case here.

Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	peptidoglycan turnover Inferred from electronic annotation. Source: InterPro
Cellular_component	outer membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	carbon-oxygen lyase activity, acting on polysaccharides Inferred from electronic annotation. Source: EC hydrolase activity, hydrolyzing O-glycosyl compounds Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Membrane-bound lytic murein transglycosylase A homolog		PRO_0000196567

Sequences

	Sequence		Length	Mass (Da)
	Q8K9A7 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: A07DCD520E5EAB72	FASTA	366	42,545
	10 20 30 40 50 60 MLNSCINKIK KKKNIKKIIL MLIFIFSVNF FTKNTNQGKQ YEDKLNKDFT NIKKINIKNK 70 80 90 100 110 120 LVNQKEFLLQ LEKIKIFSPN LYSKNISIYN AILKWLKKRA EINELNKFRI KLFQMKGVDQ 130 140 150 160 170 180 YGNVKITGYY TPIVKASKIK KNNFIYPIYR TPSNFKKNEK LPQRKDIYNG FLKKEYILAY 190 200 210 220 230 240 SDSLINNFIM EIQGSGFIDY GDNKPLIFFG YAKKNNWPYT SIGQILIKNG DIQKKNISMN 250 260 270 280 290 300 TIKNWCTHHT QKEIQNLLEK NKSFVFFQET KRKEVYGSSA VPLVEKAAIA VDKSVIKIGS 310 320 330 340 350 360 VVLVKIPVLD KNGIFIHKYE MHLLIALDVG GVIKGQHFDV YQGIGEKAGK LAGFYNHYGY AWVLKI

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013218 Genomic DNA. Translation: AAM67985.1.
RefSeq	NP_660774.1. NC_004061.1.
3D structure databases
ProteinModelPortal	Q8K9A7.
ModBase	Search...
Protein-protein interaction databases
STRING	198804.BUsg442.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM67985; AAM67985; BUsg_442.
GeneID	1005722.
KEGG	bas:BUsg442.
PATRIC	21247736. VBIBucAph100086_0467.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2821.
KO	K08304.
OMA	NQGDFLT.
ProtClustDB	PRK11162.
Enzyme and pathway databases
BioCyc	BAPH198804:GHMG-487-MONOMER.
Family and domain databases
Gene3D	2.40.40.10. 2 hits.
InterPro	IPR010611. 3D. IPR014733. Barwin-like_endoglucanase. IPR005300. Lytic_transglycosylase_MltA. IPR026044. MltA. [Graphical view]
Pfam	PF06725. 3D. 1 hit. PF03562. MltA. 1 hit. [Graphical view]
PIRSF	PIRSF019422. MltA. 1 hit.
SMART	SM00925. MltA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MLTA_BUCAP

Accession

Primary (citable) accession number: Q8K9A7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program