Q8K9A5 (THIL_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thiamine-monophosphate kinase
Short name=Thiamine-phosphate kinase
EC=2.7.4.16

Gene names

Name:	thiL
Ordered Locus Names:	BUsg_444

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thiamine phosphate = ADP + thiamine diphosphate.
Pathway	Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.
Sequence similarities	Belongs to the thiamine-monophosphate kinase family.

Ontologies

Keywords
Biological process	Thiamine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thiamine-phosphate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Thiamine-monophosphate kinase		PRO_0000096193

Sequences

	Sequence		Length	Mass (Da)
	Q8K9A5 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: DF6512D5D6DD9CDF	FASTA	323	35,838
	10 20 30 40 50 60 MEYNEFEIIS KFFKNHQKKD KNQIKGIGDD SALIKIPKNN LLAISTDTLV EGKHFLKNIT 70 80 90 100 110 120 PKDLAYKSVA VNLSDLAAMG AKPTWITLSI TMPKSDSVWL KSFSKSFFKI LNKYKLNLIG 130 140 150 160 170 180 GDTNSGPLSI TLSIYGLIEG KNALLRGNAK NGDLIYITGN LGESAAGLSL LQKKTFLKNV 190 200 210 220 230 240 KICNYLIKKH LKPIPRISEG IALRNIANAA IDISDGLISD LGHILKNSKC GADINLNTIP 250 260 270 280 290 300 ISKILTDNFK IDEYLNWALN SGEDYELCFT ISKKNIKKLN VAIKKKIIKC TCIGYITSAE 310 320 KGLNLIQNQK KIIFKKSGFN HFI

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013218 Genomic DNA. Translation: AAM67987.1.
RefSeq	NP_660776.1. NC_004061.1.
3D structure databases
ProteinModelPortal	Q8K9A5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBUCT00000000530; EBBUCP00000000530; EBBUCG00000000530.
GeneID	1005720.
GenomeReviews	Gene locus BUsg_444 in contig AE013218_GR.
KEGG	bas:BUsg444.
PATRIC	21247740. VBIBucAph100086_0469.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000008007.
HOGENOM	HBG577902.
OMA	MGAEPAW.
ProtClustDB	CLSK316267.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG444-MONOMER.
Family and domain databases
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR016188. PurM_N-like. IPR006283. ThiL. [Graphical view]
KO	K00946.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
PIRSF	PIRSF005303. Thiam_monoph_kin. 1 hit.
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR01379. ThiL. 1 hit.
ProtoNet	Search...

Entry information

Entry name

THIL_BUCAP

Accession

Primary (citable) accession number: Q8K9A5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program