ID   RIBD1_BUCAP             Reviewed;         147 AA.
AC   Q8K9A4;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-JUN-2009, entry version 46.
DE   RecName: Full=Diaminohydroxyphosphoribosylamino-pyrimidine deaminase;
DE            Short=DRAP deaminase;
DE            EC=3.5.4.26;
DE   AltName: Full=Riboflavin-specific deaminase;
GN   Name=ribD1; OrderedLocusNames=BUsg_445;
OS   Buchnera aphidicola subsp. Schizaphis graminum.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Buchnera.
OX   NCBI_TaxID=98794;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22084549; PubMed=12089438; DOI=10.1126/science.1071278;
RA   Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA   Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT   "50 million years of genomic stasis in endosymbiotic bacteria.";
RL   Science 296:2376-2379(2002).
CC   -!- CATALYTIC ACTIVITY: 2,5-diamino-6-hydroxy-4-(5-
CC       phosphoribosylamino)pyrimidine + H(2)O = 5-amino-6-(5-
CC       phosphoribosylamino)uracil + NH(3).
CC   -!- COFACTOR: Binds 1 zinc ion (By similarity).
CC   -!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; 6,7-
CC       dimethyl-8-(1-D-ribityl)lumazine from GTP: step 2/4.
CC   -!- SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase
CC       family.
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DR   EMBL; AE013218; AAM67988.1; -; Genomic_DNA.
DR   RefSeq; NP_660777.1; -.
DR   HSSP; Q12178; 1UAQ.
DR   GeneID; 1005719; -.
DR   GenomeReviews; AE013218_GR; BUsg_445.
DR   KEGG; bas:BUsg445; -.
DR   HOGENOM; Q8K9A4; -.
DR   OMA; Q8K9A4; PPVGCVL.
DR   BioCyc; BAPH198804:BUSG445-MON; -.
DR   GO; GO:0008703; F:5-amino-6-(5-phosphoribosylamino)uracil red...; IEA:InterPro.
DR   GO; GO:0008835; F:diaminohydroxyphosphoribosylaminopyrimidine...; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009231; P:riboflavin biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR016192; APOBEC/CMP_deaminase_Zn-bd.
DR   InterPro; IPR002125; CMP_dCMP_Zn_bd.
DR   InterPro; IPR004794; Eubact_ribD.
DR   PANTHER; PTHR11079:SF10; Eubact_ribD; 1.
DR   Pfam; PF00383; dCMP_cyt_deam_1; 1.
DR   TIGRFAMs; TIGR00326; eubact_ribD; 1.
DR   PROSITE; PS00903; CYT_DCMP_DEAMINASES; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Metal-binding; Riboflavin biosynthesis;
KW   Zinc.
FT   CHAIN         1    147       Diaminohydroxyphosphoribosylamino-
FT                                pyrimidine deaminase.
FT                                /FTId=PRO_0000171726.
FT   ACT_SITE     52     52       Proton donor (By similarity).
FT   METAL        50     50       Zinc; catalytic (By similarity).
FT   METAL        75     75       Zinc; catalytic (By similarity).
FT   METAL        84     84       Zinc; catalytic (By similarity).
SQ   SEQUENCE   147 AA;  16233 MW;  EBCCF068610EECF0 CRC64;
     MKDRFYMTRA IKLSKLGEFT TSPNPNVGCV IVQNKKIVGE GWHKKYGENH AEINALNMAG
     EKAKGSTAYI TLEPCNHFGK TPPCCDAIIQ SGIKNVIISS LDPNPKVSGK GVLYLRKKGI
     SVKIGLMSKE SQKYNKGFFK RMRTGLP
//