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Q8K9A0 (ISPA_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Farnesyl diphosphate synthase
Short name=FPP synthase
EC=2.5.1.10
Alternative name(s):
(2E,6E)-farnesyl diphosphate synthase
Geranyltranstransferase
Gene names
Name:ispA
Ordered Locus Names:BUsg_449
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.

Cofactor

Binds 3 magnesium ions per subunit By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the FPP/GGPP synthase family.

Ontologies

Keywords
   Biological processIsoprene biosynthesis
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processisoprenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiongeranyltranstransferase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294Farnesyl diphosphate synthase
PRO_0000123989

Sites

Metal binding841Magnesium 1 By similarity
Metal binding841Magnesium 2 By similarity
Metal binding901Magnesium 1 By similarity
Metal binding901Magnesium 2 By similarity
Metal binding2231Magnesium 3 By similarity
Binding site451Isopentenyl diphosphate By similarity
Binding site481Isopentenyl diphosphate By similarity
Binding site771Isopentenyl diphosphate By similarity
Binding site951Geranyl diphosphate By similarity
Binding site961Isopentenyl diphosphate By similarity
Binding site1811Geranyl diphosphate By similarity
Binding site1821Geranyl diphosphate By similarity
Binding site2201Geranyl diphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8K9A0 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 7D7D901C7213ED0A

FASTA29433,881
        10         20         30         40         50         60 
MNFSHLYDIY YNRINKKLFE IIQELPFQDS VLFRAMKYST LSGGKRLRAC LIYATGETFQ 

        70         80         90        100        110        120 
VNIAALDVIS AAVELVHSYS LIHDDLPCID NDYFRRGKIS CHIKYGENFA LLAGDALQGL 

       130        140        150        160        170        180 
AFNILSNSNM PGVHDSIRLK MIAEFSNAIG YSGMCIGQML DLEKERKKIN ISELEKINLY 

       190        200        210        220        230        240 
KTAFLIRCSI RLAYFASNNF SKEVLFILDK FSVSIGLAFQ IQDDILDLKN DIKKLESKRN 

       250        260        270        280        290 
KTKNTYPLLI GLKKSKIKIK ELYKEAFFTL EILKKNFNVN ILKLLTQFIM KRFK

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References

[1]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE013218 Genomic DNA. Translation: AAM67992.1.
RefSeqNP_660781.1. NC_004061.1.

3D structure databases

ProteinModelPortalQ8K9A0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000000229; EBBUCP00000000229; EBBUCG00000000229.
GeneID1005716.
GenomeReviewsGene locus BUsg_449 in contig AE013218_GR.
KEGGbas:BUsg449.
PATRIC21247750. VBIBucAph100086_0474.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000008059.
HOGENOMHBG732667.
OMALQMEREN.
ProtClustDBCLSK316270.

Enzyme and pathway databases

BioCycBAPH198804:BUSG449-MONOMER.

Family and domain databases

InterProIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
Gene3DG3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
KOK00795.
PANTHERPTHR12001. Polyprenyl_synt. 1 hit.
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMSSF48576. Terpenoid_synth. 1 hit.
PROSITEPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameISPA_BUCAP
AccessionPrimary (citable) accession number: Q8K9A0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names

SIMILARITY comments

Index of protein domains and families

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