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Q8K993 (CYOA_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome bo(3) ubiquinol oxidase subunit 2
Alternative name(s):
Cytochrome o ubiquinol oxidase subunit 2
Short name=Cytochrome o subunit 2
Oxidase bo(3) subunit 2
Ubiquinol oxidase polypeptide II
Ubiquinol oxidase subunit 2
Gene names
Name:cyoA
Ordered Locus Names:BUsg_456
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome bo3 ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron By similarity.

Subunit structure

Heterooctamer of two A chains, two B chains, two C chains and two D chains By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 290266Cytochrome bo(3) ubiquinol oxidase subunit 2
PRO_0000006073

Regions

Topological domain25 – 4218Extracellular Potential
Transmembrane43 – 6321Helical; Potential
Topological domain64 – 8724Cytoplasmic Potential
Transmembrane88 – 10821Helical; Potential
Topological domain109 – 290182Extracellular Potential

Amino acid modifications

Lipidation251N-palmitoyl cysteine Potential
Lipidation251S-diacylglycerol cysteine Potential

Sequences

Sequence LengthMass (Da)Tools
Q8K993 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 3D80A02A84732963

FASTA29033,730
        10         20         30         40         50         60 
MISINFNNFF KTLLLILIAF TLHGCDSILF NPHGIIAIQE CSILLISFLI MLFVIIPVIF 

        70         80         90        100        110        120 
MTIYFSVKYR ASNINAKYKP DWCDSKKIEI IVWTIPISII LFLAFVTWNY SHILDPKKSI 

       130        140        150        160        170        180 
ISKYKPIKID VVSLDWRWLF IYPEYHIATI NEIMFPINRS IIFHITSNSV MNSFFIPSLG 

       190        200        210        220        230        240 
SQIYAMPGMM TTLNLMSNSP GKYKGISSNY SGKGFSNMKF TAISVLNIKD FENWIKKAQQ 

       250        260        270        280        290 
SPKKLNKMSI FNIISLPNEN HFIEYFSDVK KNLFYEIINQ TYSKNKVFKH 

« Hide

References

[1]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE013218 Genomic DNA. Translation: AAM67999.1.
RefSeqNP_660788.1. NC_004061.1.

3D structure databases

ProteinModelPortalQ8K993.
SMRQ8K993. Positions 125-281.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198804.BUsg456.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM67999; AAM67999; BUsg_456.
GeneID1005709.
KEGGbas:BUsg456.
PATRIC21247766. VBIBucAph100086_0482.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1622.
KOK02297.
OMANHGEMNH.
OrthoDBEOG6PS5TJ.
ProtClustDBCLSK316278.

Enzyme and pathway databases

BioCycBAPH198804:GHMG-480-MONOMER.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR012141. Bo-type_Ubol_Oxase_su_II.
IPR010514. COX_ARM.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
IPR006333. Cyt_o_ubiquinol_oxidase_su2.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF06481. COX_ARM. 1 hit.
[Graphical view]
PIRSFPIRSF000292. Ubi_od_II. 1 hit.
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR01433. CyoA. 1 hit.
PROSITEPS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYOA_BUCAP
AccessionPrimary (citable) accession number: Q8K993
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names