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Q8K990

- CLPP_BUCAP

UniProt

Q8K990 - CLPP_BUCAP

Protein

ATP-dependent Clp protease proteolytic subunit

Gene

clpP

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.UniRule annotation

    Catalytic activityi

    Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei102 – 1021NucleophileUniRule annotation
    Active sitei127 – 1271UniRule annotation

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-483-MONOMER.

    Protein family/group databases

    MEROPSiS14.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent Clp protease proteolytic subunitUniRule annotation (EC:3.4.21.92UniRule annotation)
    Alternative name(s):
    Endopeptidase ClpUniRule annotation
    Gene namesi
    Name:clpPUniRule annotation
    Ordered Locus Names:BUsg_459
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 197197ATP-dependent Clp protease proteolytic subunitPRO_0000179520Add
    BLAST

    Interactioni

    Subunit structurei

    Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

    Protein-protein interaction databases

    STRINGi198804.BUsg459.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K990.
    SMRiQ8K990. Positions 7-197.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S14 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0740.
    KOiK01358.
    OMAiKGERSFD.
    OrthoDBiEOG6Z3KQ0.

    Family and domain databases

    Gene3Di3.90.226.10. 1 hit.
    HAMAPiMF_00444. ClpP.
    InterProiIPR001907. ClpP.
    IPR029045. ClpP/crotonase-like_dom.
    IPR023562. ClpP/TepA.
    IPR018215. ClpP_AS.
    [Graphical view]
    PANTHERiPTHR10381. PTHR10381. 1 hit.
    PfamiPF00574. CLP_protease. 1 hit.
    [Graphical view]
    PRINTSiPR00127. CLPPROTEASEP.
    SUPFAMiSSF52096. SSF52096. 1 hit.
    TIGRFAMsiTIGR00493. clpP. 1 hit.
    PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
    PS00381. CLP_PROTEASE_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K990-1 [UniParc]FASTAAdd to Basket

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    MKSNSVLIPM VVEQHSRGER SYDIYSRLLK ERIIFITGTI EDNMASSIVA    50
    QMLFLEAESL DKDIFLYINS PGGIITSGMS IYDTMQFIKP DVNTICIGQA 100
    CSMAAFLLSS GTKGKRSCLP NARIMIHQPL GGYQGQASDI AIHAEEINKM 150
    KKKLNKLMSL NTGQSIKKIN KDTERDCFLS AHESIKYGLI DLILTQR 197
    Length:197
    Mass (Da):21,970
    Last modified:October 1, 2002 - v1
    Checksum:i93C96E0CC41DAC2F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM68002.1.
    RefSeqiNP_660791.1. NC_004061.1.
    WP_011053969.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM68002; AAM68002; BUsg_459.
    GeneIDi1005706.
    KEGGibas:BUsg459.
    PATRICi21247774. VBIBucAph100086_0486.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM68002.1 .
    RefSeqi NP_660791.1. NC_004061.1.
    WP_011053969.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8K990.
    SMRi Q8K990. Positions 7-197.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg459.

    Protein family/group databases

    MEROPSi S14.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM68002 ; AAM68002 ; BUsg_459 .
    GeneIDi 1005706.
    KEGGi bas:BUsg459.
    PATRICi 21247774. VBIBucAph100086_0486.

    Phylogenomic databases

    eggNOGi COG0740.
    KOi K01358.
    OMAi KGERSFD.
    OrthoDBi EOG6Z3KQ0.

    Enzyme and pathway databases

    BioCyci BAPH198804:GHMG-483-MONOMER.

    Family and domain databases

    Gene3Di 3.90.226.10. 1 hit.
    HAMAPi MF_00444. ClpP.
    InterProi IPR001907. ClpP.
    IPR029045. ClpP/crotonase-like_dom.
    IPR023562. ClpP/TepA.
    IPR018215. ClpP_AS.
    [Graphical view ]
    PANTHERi PTHR10381. PTHR10381. 1 hit.
    Pfami PF00574. CLP_protease. 1 hit.
    [Graphical view ]
    PRINTSi PR00127. CLPPROTEASEP.
    SUPFAMi SSF52096. SSF52096. 1 hit.
    TIGRFAMsi TIGR00493. clpP. 1 hit.
    PROSITEi PS00382. CLP_PROTEASE_HIS. 1 hit.
    PS00381. CLP_PROTEASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiCLPP_BUCAP
    AccessioniPrimary (citable) accession number: Q8K990
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3