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Q8K990

- CLPP_BUCAP

UniProt

Q8K990 - CLPP_BUCAP

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Protein

ATP-dependent Clp protease proteolytic subunit

Gene

clpP

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei102 – 1021NucleophileUniRule annotation
Active sitei127 – 1271UniRule annotation

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-483-MONOMER.

Protein family/group databases

MEROPSiS14.001.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunitUniRule annotation (EC:3.4.21.92UniRule annotation)
Alternative name(s):
Endopeptidase ClpUniRule annotation
Gene namesi
Name:clpPUniRule annotation
Ordered Locus Names:BUsg_459
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197ATP-dependent Clp protease proteolytic subunitPRO_0000179520Add
BLAST

Interactioni

Subunit structurei

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

Protein-protein interaction databases

STRINGi198804.BUsg459.

Structurei

3D structure databases

ProteinModelPortaliQ8K990.
SMRiQ8K990. Positions 7-197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S14 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0740.
KOiK01358.
OMAiKGERSFD.
OrthoDBiEOG6Z3KQ0.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_00444. ClpP.
InterProiIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view]
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00493. clpP. 1 hit.
PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K990-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSNSVLIPM VVEQHSRGER SYDIYSRLLK ERIIFITGTI EDNMASSIVA
60 70 80 90 100
QMLFLEAESL DKDIFLYINS PGGIITSGMS IYDTMQFIKP DVNTICIGQA
110 120 130 140 150
CSMAAFLLSS GTKGKRSCLP NARIMIHQPL GGYQGQASDI AIHAEEINKM
160 170 180 190
KKKLNKLMSL NTGQSIKKIN KDTERDCFLS AHESIKYGLI DLILTQR
Length:197
Mass (Da):21,970
Last modified:October 1, 2002 - v1
Checksum:i93C96E0CC41DAC2F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM68002.1.
RefSeqiNP_660791.1. NC_004061.1.
WP_011053969.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM68002; AAM68002; BUsg_459.
GeneIDi1005706.
KEGGibas:BUsg459.
PATRICi21247774. VBIBucAph100086_0486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM68002.1 .
RefSeqi NP_660791.1. NC_004061.1.
WP_011053969.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8K990.
SMRi Q8K990. Positions 7-197.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg459.

Protein family/group databases

MEROPSi S14.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM68002 ; AAM68002 ; BUsg_459 .
GeneIDi 1005706.
KEGGi bas:BUsg459.
PATRICi 21247774. VBIBucAph100086_0486.

Phylogenomic databases

eggNOGi COG0740.
KOi K01358.
OMAi KGERSFD.
OrthoDBi EOG6Z3KQ0.

Enzyme and pathway databases

BioCyci BAPH198804:GHMG-483-MONOMER.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
HAMAPi MF_00444. ClpP.
InterProi IPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view ]
PANTHERi PTHR10381. PTHR10381. 1 hit.
Pfami PF00574. CLP_protease. 1 hit.
[Graphical view ]
PRINTSi PR00127. CLPPROTEASEP.
SUPFAMi SSF52096. SSF52096. 1 hit.
TIGRFAMsi TIGR00493. clpP. 1 hit.
PROSITEi PS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiCLPP_BUCAP
AccessioniPrimary (citable) accession number: Q8K990
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3