Q8K987 (PPID_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase D
Short name=PPIase D
EC=5.2.1.8

Alternative name(s):
Rotamase D

Gene names

Name:	ppiD
Ordered Locus Names:	BUsg_462

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Schizaphis graminum)

Protein attributes

Sequence length	621 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	PPIases accelerate the folding of proteins By similarity.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subcellular location	Cell membrane; Single-pass type II membrane protein Potential.
Sequence similarities	Contains 1 PpiC domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Isomerase Rotamase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW protein peptidyl-prolyl isomerization Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 621	621	Peptidyl-prolyl cis-trans isomerase D		PRO_0000193421
Regions
	Topological domain	1 – 10	10	Cytoplasmic Potential
	Transmembrane	11 – 31	21	Helical; Potential
	Topological domain	32 – 621	590	Extracellular Potential
	Domain	228 – 355	128	PpiC

Sequences

	Sequence		Length	Mass (Da)
	Q8K987 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 5B7A89B253144C7C	FASTA	621	74,140
	10 20 30 40 50 60 MIKYLKSRLN IIIVKCILGI IILSLVFGTI NNYFNRDTTR YIAKVNGEEI SFITLQKMYI 70 80 90 100 110 120 DERKKQEKIL GQDFEKIKKN KKFKEETYNY ILSQLINNIL LEQYTKRMNF NIQDNEIKKI 130 140 150 160 170 180 IFNIPIFQEN NEFNKKKYLN YLSSKNLTHY EYVSLIRKKL NTTYLINAIS ETDFILDNEQ 190 200 210 220 230 240 KKIIKLLSEK RIIKKAIIKI NPIINNQKVT EKEINNYFDQ HKNEFYTPEK FKISYIQLKP 250 260 270 280 290 300 NKFKIQCSNE EIKNWYKKNI DKYSNQERRQ YSIIQTKTKN EALSILSELK KGEDFSKIAK 310 320 330 340 350 360 EKSIDPFSSE QGGNIGWITK NFVPNEIKIA NLEKIDQISN IIKFNNNFLI IKLNKILPKK 370 380 390 400 410 420 YKKISEVSDL IENEIKYQKS LNTYKKLKDK IAIIAKKNIN RFDLILKKTN ILPKETNWFD 430 440 450 460 470 480 KDSVPKELQN PILKKIIFKK GLLDRQKKLK SHSGLIVLND HQSFLLSIKN FQKKRIKKLK 490 500 510 520 530 540 DIKRNIVNKL KYIKAVEKTK NKLKKILFQL KIGNEHILKK ENIIFEEYET VSRYDKNPNI 550 560 570 580 590 600 SVIFAMPHPK EEKNVYTMYQ NKNKNFVIAL LDKVYNEKFS NEEEKIIIKY LEKNNIDVTF 610 620 QCFLQNLHRK ATILYNKTDN F

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013218 Genomic DNA. Translation: AAM68005.1.
RefSeq	NP_660794.1. NC_004061.1.
3D structure databases
ProteinModelPortal	Q8K987.
ModBase	Search...
Protein-protein interaction databases
STRING	198804.BUsg462.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM68005; AAM68005; BUsg_462.
GeneID	1005703.
KEGG	bas:BUsg462.
PATRIC	21247780. VBIBucAph100086_0489.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0760.
KO	K03770.
OMA	ANEDFIN.
ProtClustDB	CLSK315500.
Enzyme and pathway databases
BioCyc	BAPH198804:GHMG-507-MONOMER.
Family and domain databases
InterPro	IPR000297. PPIase_PpiC. IPR027304. Trigger_fact/SurA_dom. [Graphical view]
Pfam	PF13145. Rotamase_2. 1 hit. [Graphical view]
SUPFAM	SSF109998. Trigger_fac_C_bac. 1 hit.
PROSITE	PS01096. PPIC_PPIASE_1. False negative. PS50198. PPIC_PPIASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPID_BUCAP

Accession

Primary (citable) accession number: Q8K987

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program