Reviewed, UniProtKB/Swiss-Prot Q8K985 (MDLA_BUCAP)

Names and origin

Protein names

Recommended name:
    Multidrug resistance-like ATP-binding protein mdlA
    EC=3.6.3.44

Gene names

Name:	mdlA
Ordered Locus Names:	BUsg_464

Organism

Buchnera aphidicola subsp. Schizaphis graminum [Complete proteome] [HAMAP]

Taxonomic identifier

98794 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	581 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family. [View classification] Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW xenobiotic-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 581	581	Multidrug resistance-like ATP-binding protein mdlA		PRO_0000092494
Regions
	Transmembrane	23 – 43	21	Potential
	Transmembrane	53 – 73	21	Potential
	Transmembrane	127 – 149	23	Potential
	Transmembrane	153 – 175	23	Potential
	Transmembrane	247 – 267	21	Potential
	Transmembrane	280 – 300	21	Potential
	Domain	18 – 303	286	ABC transmembrane type-1
	Domain	337 – 571	235	ABC transporter
	Nucleotide binding	369 – 376	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8K985-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 004B5AC7FE5A7B96	FASTA	581	66,160
	10 20 30 40 50 60 MRLFNQLKWY FIKEWKRYLG SIILLIIIAF LQLLPPKIIG ILIDLIIKEK MSGFEILPWI 70 80 90 100 110 120 SIILLIAIIV YILRYLWRIL LFGASYQLAT ELRVKFYSYL SKQSEIFFLK NRTGDLIARA 130 140 150 160 170 180 TNDVDRVVFA AGEGVLTLVD SSVMGISVLI VMITQISWLL TIISLIPMPI MAILIKKYGK 190 200 210 220 230 240 KLHDTFRNAQ SAFSLLNNQT QEILTSIRMI RAFGLEKNQL KKFNNIVNDT GKKNMEVAEI 250 260 270 280 290 300 DARFDPVIYL SVAFSNLLAI TAGGWLVWNN TITIGKLTSF IMYLGLMIWP MLALAWMFNI 310 320 330 340 350 360 VERGSAAWDR IHSIINQNLY IEDGKKTIIN MNGKLNINID MFFYPKNKKP SLKNIYLSLN 370 380 390 400 410 420 PGKTLGICGP TGAGKSTLLK LIQRQFKIHK GEILYNSSSL LELKIDYWRS KIGVVNQTSF 430 440 450 460 470 480 LFSDSISNNI SLGKPKASQK EIEKAAKLAD IHKDIVCLPQ GYNTQVGERG VMLSGGQKQR 490 500 510 520 530 540 IAIARALLLN TEILILDDAL SAVDGKTENN ILKNLKKWKD KGYSLIIVAH RLSALIHADE 550 560 570 580 IIVIKEGTII QRGNHEKLIK EKNWYKSMYD HQKIQTEIEN F

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE013218 Genomic DNA. Translation: AAM68007.1.
RefSeq	NP_660796.1.
3D structure databases
HSSP	HSSP built from PDB template 1MT0 based on UniProtKB P08716.
ModBase	Search...
Genome annotation databases
GeneID	1005701.
GenomeReviews	Gene locus BUsg_464 in contig AE013218_GR.
KEGG	bas:BUsg464.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8K985.
OMA	WNNTITI.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG464-MON.
Family and domain databases
InterPro	IPR001140. ABC_TM_transpt. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00664. ABC_membrane. 1 hit. PF00005. ABC_tran. 1 hit. [Graphical view]
ProDom	PD000006. ABC_transporter. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MDLA_BUCAP

Accession

Primary (citable) accession number: Q8K985

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2002
Last modified:	November 3, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)