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Protein

Multidrug resistance-like ATP-binding protein MdlB

Gene

mdlB

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi375 – 382ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH198804:G1FZU-490-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-like ATP-binding protein MdlB (EC:3.6.3.44)
Gene namesi
Name:mdlB
Ordered Locus Names:BUsg_465
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000416 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 46HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei61 – 81HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei142 – 162HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei165 – 185HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei258 – 278HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000925001 – 580Multidrug resistance-like ATP-binding protein MdlBAdd BLAST580

Proteomic databases

PRIDEiQ8K984

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg465

Structurei

3D structure databases

ProteinModelPortaliQ8K984
SMRiQ8K984
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 310ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST286
Domaini341 – 575ABC transporterPROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1 Bacteria
COG1132 LUCA
KOiK18890
OMAiDRICVFL
OrthoDBiPOG091H00DB

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K984-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHLIQFWPI LKRLIIYAIP WKKKIILAFF LLLSGATSEV LGPILISYFI
60 70 80 90 100
NNILSQHQLN FQLILIIIVI FIMLQILAVF FNYFQSILFN KIAVGIVNKL
110 120 130 140 150
RNDVMKAALN QPISEFDSQP IGQMISKVTN DTEVIKELYD TVGPTFFRSI
160 170 180 190 200
TLIIIILFAM FTLEWHMAII TIFIIPLVII VMSIYQYYST PLLRNVRYYV
210 220 230 240 250
ANINNKFNET INGMNVIQQF RQQTRFENNI KESSELHYLA RMKILKLDGF
260 270 280 290 300
LLRPLLSLLS ALVLCSFMFL FSYFSIGVYE VGVLYAFITY LGRLNEPLIS
310 320 330 340 350
ITIQQSILQQ AIVAGERIFS LIDSPKQKYG NNEEEIKSGK INIKNLSFKY
360 370 380 390 400
KESGENILNN INIYIPSKSF VAFVGQTGSG KSTLANLLMG YYPIKHGKIY
410 420 430 440 450
LDDKSINCIS HDVLRKNILM VQQDPIVLAD TFSSNITLGK KISEEKIWNV
460 470 480 490 500
LKTVHLSSLV QSMPKGIYSI LGEEGNNLSL GQKQLLAIAR ILVRNPKILI
510 520 530 540 550
LDEATANIDS GTEKLIQTTL SSIRAKTTLV VIAHRLSTVI EADMIVVLKK
560 570 580
GKIVELGTHK QLLEKKGFYW KMYNFQLFNC
Length:580
Mass (Da):66,171
Last modified:October 1, 2002 - v1
Checksum:i4D0098F4F8571A2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA Translation: AAM68008.1
RefSeqiWP_011053975.1, NC_004061.1

Genome annotation databases

EnsemblBacteriaiAAM68008; AAM68008; BUsg_465
KEGGibas:BUsg_465

Similar proteinsi

Entry informationi

Entry nameiMDLB_BUCAP
AccessioniPrimary (citable) accession number: Q8K984
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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