Reviewed, UniProtKB/Swiss-Prot Q8K984 (MDLB_BUCAP)

Names and origin

Protein names

Recommended name:
    Multidrug resistance-like ATP-binding protein mdlB
    EC=3.6.3.44

Gene names

Name:	mdlB
Ordered Locus Names:	BUsg_465

Organism

Buchnera aphidicola subsp. Schizaphis graminum [Complete proteome] [HAMAP]

Taxonomic identifier

98794 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	580 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family. [View classification] Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW xenobiotic-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 580	580	Multidrug resistance-like ATP-binding protein mdlB		PRO_0000092500
Regions
	Transmembrane	26 – 46	21	Potential
	Transmembrane	61 – 81	21	Potential
	Transmembrane	142 – 162	21	Potential
	Transmembrane	165 – 185	21	Potential
	Transmembrane	258 – 278	21	Potential
	Domain	25 – 310	286	ABC transmembrane type-1
	Domain	341 – 575	235	ABC transporter
	Nucleotide binding	375 – 382	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8K984-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 4D0098F4F8571A2A	FASTA	580	66,171
	10 20 30 40 50 60 MDHLIQFWPI LKRLIIYAIP WKKKIILAFF LLLSGATSEV LGPILISYFI NNILSQHQLN 70 80 90 100 110 120 FQLILIIIVI FIMLQILAVF FNYFQSILFN KIAVGIVNKL RNDVMKAALN QPISEFDSQP 130 140 150 160 170 180 IGQMISKVTN DTEVIKELYD TVGPTFFRSI TLIIIILFAM FTLEWHMAII TIFIIPLVII 190 200 210 220 230 240 VMSIYQYYST PLLRNVRYYV ANINNKFNET INGMNVIQQF RQQTRFENNI KESSELHYLA 250 260 270 280 290 300 RMKILKLDGF LLRPLLSLLS ALVLCSFMFL FSYFSIGVYE VGVLYAFITY LGRLNEPLIS 310 320 330 340 350 360 ITIQQSILQQ AIVAGERIFS LIDSPKQKYG NNEEEIKSGK INIKNLSFKY KESGENILNN 370 380 390 400 410 420 INIYIPSKSF VAFVGQTGSG KSTLANLLMG YYPIKHGKIY LDDKSINCIS HDVLRKNILM 430 440 450 460 470 480 VQQDPIVLAD TFSSNITLGK KISEEKIWNV LKTVHLSSLV QSMPKGIYSI LGEEGNNLSL 490 500 510 520 530 540 GQKQLLAIAR ILVRNPKILI LDEATANIDS GTEKLIQTTL SSIRAKTTLV VIAHRLSTVI 550 560 570 580 EADMIVVLKK GKIVELGTHK QLLEKKGFYW KMYNFQLFNC

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE013218 Genomic DNA. Translation: AAM68008.1.
RefSeq	NP_660797.1.
3D structure databases
HSSP	HSSP built from PDB template 1MT0 based on UniProtKB P08716.
ModBase	Search...
Genome annotation databases
GeneID	1005700.
GenomeReviews	Gene locus BUsg_465 in contig AE013218_GR.
KEGG	bas:BUsg465.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8K984.
OMA	KFNETIN.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG465-MON.
Family and domain databases
InterPro	IPR001140. ABC_TM_transpt. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00664. ABC_membrane. 1 hit. PF00005. ABC_tran. 1 hit. [Graphical view]
ProDom	PD000006. ABC_transporter. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MDLB_BUCAP

Accession

Primary (citable) accession number: Q8K984

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2002
Last modified:	November 3, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)