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Protein

Multidrug resistance-like ATP-binding protein MdlB

Gene

mdlB

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi375 – 382ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-like ATP-binding protein MdlB (EC:3.6.3.44)
Gene namesi
Name:mdlB
Ordered Locus Names:BUsg_465
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000416 Componenti: Chromosome

Subcellular locationi

Q8K984:

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 46HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei61 – 81HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei142 – 162HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei165 – 185HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei258 – 278HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000925001 – 580Multidrug resistance-like ATP-binding protein MdlBAdd BLAST580

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg465.

Structurei

3D structure databases

ProteinModelPortaliQ8K984.
SMRiQ8K984.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 310ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST286
Domaini341 – 575ABC transporterPROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK18890.
OMAiVFITQRL.
OrthoDBiPOG091H00DB.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K984-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHLIQFWPI LKRLIIYAIP WKKKIILAFF LLLSGATSEV LGPILISYFI
60 70 80 90 100
NNILSQHQLN FQLILIIIVI FIMLQILAVF FNYFQSILFN KIAVGIVNKL
110 120 130 140 150
RNDVMKAALN QPISEFDSQP IGQMISKVTN DTEVIKELYD TVGPTFFRSI
160 170 180 190 200
TLIIIILFAM FTLEWHMAII TIFIIPLVII VMSIYQYYST PLLRNVRYYV
210 220 230 240 250
ANINNKFNET INGMNVIQQF RQQTRFENNI KESSELHYLA RMKILKLDGF
260 270 280 290 300
LLRPLLSLLS ALVLCSFMFL FSYFSIGVYE VGVLYAFITY LGRLNEPLIS
310 320 330 340 350
ITIQQSILQQ AIVAGERIFS LIDSPKQKYG NNEEEIKSGK INIKNLSFKY
360 370 380 390 400
KESGENILNN INIYIPSKSF VAFVGQTGSG KSTLANLLMG YYPIKHGKIY
410 420 430 440 450
LDDKSINCIS HDVLRKNILM VQQDPIVLAD TFSSNITLGK KISEEKIWNV
460 470 480 490 500
LKTVHLSSLV QSMPKGIYSI LGEEGNNLSL GQKQLLAIAR ILVRNPKILI
510 520 530 540 550
LDEATANIDS GTEKLIQTTL SSIRAKTTLV VIAHRLSTVI EADMIVVLKK
560 570 580
GKIVELGTHK QLLEKKGFYW KMYNFQLFNC
Length:580
Mass (Da):66,171
Last modified:October 1, 2002 - v1
Checksum:i4D0098F4F8571A2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM68008.1.
RefSeqiWP_011053975.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM68008; AAM68008; BUsg_465.
KEGGibas:BUsg_465.

Similar proteinsi

Entry informationi

Entry nameiMDLB_BUCAP
AccessioniPrimary (citable) accession number: Q8K984
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: October 25, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families