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Q8K980

- KAD_BUCAP

UniProt

Q8K980 - KAD_BUCAP

Protein

Adenylate kinase

Gene

adk

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.UniRule annotation

    Catalytic activityi

    ATP + AMP = 2 ADP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei31 – 311AMPUniRule annotation
    Binding sitei36 – 361AMPUniRule annotation
    Binding sitei92 – 921AMPUniRule annotation
    Binding sitei123 – 1231ATPUniRule annotation
    Binding sitei156 – 1561AMPUniRule annotation
    Binding sitei167 – 1671AMPUniRule annotation
    Binding sitei200 – 2001ATP; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 156ATPUniRule annotation
    Nucleotide bindingi57 – 593AMPUniRule annotation
    Nucleotide bindingi85 – 884AMPUniRule annotation
    Nucleotide bindingi132 – 1332ATPUniRule annotation

    GO - Molecular functioni

    1. adenylate kinase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. AMP salvage Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-493-MONOMER.
    UniPathwayiUPA00588; UER00649.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate kinaseUniRule annotation (EC:2.7.4.3UniRule annotation)
    Short name:
    AKUniRule annotation
    Alternative name(s):
    ATP-AMP transphosphorylaseUniRule annotation
    ATP:AMP phosphotransferaseUniRule annotation
    Adenylate monophosphate kinaseUniRule annotation
    Gene namesi
    Name:adkUniRule annotation
    Ordered Locus Names:BUsg_469
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 214214Adenylate kinasePRO_0000158744Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi198804.BUsg469.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K980.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni30 – 5930NMPbindUniRule annotationAdd
    BLAST
    Regioni122 – 15938LIDAdd
    BLAST

    Domaini

    Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.UniRule annotation

    Sequence similaritiesi

    Belongs to the adenylate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0563.
    KOiK00939.
    OMAiDYVINIK.
    OrthoDBiEOG679TH4.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00235. Adenylate_kinase_Adk.
    InterProiIPR006259. Adenyl_kin_sub.
    IPR000850. Adenylat/UMP-CMP_kin.
    IPR007862. Adenylate_kinase_lid-dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR23359. PTHR23359. 1 hit.
    PfamiPF05191. ADK_lid. 1 hit.
    [Graphical view]
    PRINTSiPR00094. ADENYLTKNASE.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01351. adk. 1 hit.
    PROSITEiPS00113. ADENYLATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K980-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRIILLGAPG TGKGTQAKLI TENYNIPKIS TGDILRENIQ KKNTIGKKIH    50
    NILKNGELVS NRIVCNLIGE RIQKKDCIHG FLLDGFPRTQ KQAEYISNLK 100
    IKIDYVLELI VPYELILKRI CGRRVHTPSG RIYNINYNPP REEGKDDLTQ 150
    EKLTIREDDT IEIVKKRLEN YEKNSFLLNK YYLREKKLKK LQYFKIDGKQ 200
    SIYKIQREIK MMLK 214
    Length:214
    Mass (Da):25,091
    Last modified:October 1, 2002 - v1
    Checksum:i723A6A0EA3044DB3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM68012.1.
    RefSeqiNP_660801.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM68012; AAM68012; BUsg_469.
    GeneIDi1005532.
    KEGGibas:BUsg469.
    PATRICi21247794. VBIBucAph100086_0496.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM68012.1 .
    RefSeqi NP_660801.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8K980.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg469.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM68012 ; AAM68012 ; BUsg_469 .
    GeneIDi 1005532.
    KEGGi bas:BUsg469.
    PATRICi 21247794. VBIBucAph100086_0496.

    Phylogenomic databases

    eggNOGi COG0563.
    KOi K00939.
    OMAi DYVINIK.
    OrthoDBi EOG679TH4.

    Enzyme and pathway databases

    UniPathwayi UPA00588 ; UER00649 .
    BioCyci BAPH198804:GHMG-493-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00235. Adenylate_kinase_Adk.
    InterProi IPR006259. Adenyl_kin_sub.
    IPR000850. Adenylat/UMP-CMP_kin.
    IPR007862. Adenylate_kinase_lid-dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR23359. PTHR23359. 1 hit.
    Pfami PF05191. ADK_lid. 1 hit.
    [Graphical view ]
    PRINTSi PR00094. ADENYLTKNASE.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01351. adk. 1 hit.
    PROSITEi PS00113. ADENYLATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiKAD_BUCAP
    AccessioniPrimary (citable) accession number: Q8K980
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3