Q8K980 (KAD_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate kinase
Short name=AK
EC=2.7.4.3

Alternative name(s):
ATP-AMP transphosphorylase

Gene names

Name:	adk
Ordered Locus Names:	BUsg_469

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Schizaphis graminum)

Protein attributes

Sequence length	214 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth By similarity. HAMAP-Rule MF_00235
Catalytic activity	ATP + AMP = 2 ADP. HAMAP-Rule MF_00235
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1. HAMAP-Rule MF_00235
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Domain	Consists of three domains, a large central CORE domain and two small peripheral domains, AMP binding and LID. The LID domain closes over the site of phosphoryl transfer upon ATP binding By similarity. HAMAP-Rule MF_00235
Sequence similarities	Belongs to the adenylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	AMP salvage Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP adenylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 214	214	Adenylate kinase HAMAP-Rule MF_00235		PRO_0000158744
Regions
	Nucleotide binding	7 – 15	9	ATP By similarity
	Nucleotide binding	31 – 59	29	AMP By similarity
	Region	122 – 159	38	LID HAMAP-Rule MF_00235

Sequences

	Sequence		Length	Mass (Da)
	Q8K980 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 723A6A0EA3044DB3	FASTA	214	25,091
	10 20 30 40 50 60 MRIILLGAPG TGKGTQAKLI TENYNIPKIS TGDILRENIQ KKNTIGKKIH NILKNGELVS 70 80 90 100 110 120 NRIVCNLIGE RIQKKDCIHG FLLDGFPRTQ KQAEYISNLK IKIDYVLELI VPYELILKRI 130 140 150 160 170 180 CGRRVHTPSG RIYNINYNPP REEGKDDLTQ EKLTIREDDT IEIVKKRLEN YEKNSFLLNK 190 200 210 YYLREKKLKK LQYFKIDGKQ SIYKIQREIK MMLK

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013218 Genomic DNA. Translation: AAM68012.1.
RefSeq	NP_660801.1. NC_004061.1.
3D structure databases
ProteinModelPortal	Q8K980.
ModBase	Search...
Protein-protein interaction databases
STRING	198804.BUsg469.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM68012; AAM68012; BUsg_469.
GeneID	1005532.
KEGG	bas:BUsg469.
PATRIC	21247794. VBIBucAph100086_0496.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0563.
KO	K00939.
OMA	HEPSGRV.
ProtClustDB	PRK00279.
Enzyme and pathway databases
BioCyc	BAPH198804:GHMG-514-MONOMER.
UniPathway	UPA00588; UER00649.
Family and domain databases
HAMAP	MF_00235. Adenylate_kinase_Adk.
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_lid-dom. [Graphical view]
PANTHER	PTHR23359. PTHR23359. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
TIGRFAMs	TIGR01351. adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD_BUCAP

Accession

Primary (citable) accession number: Q8K980

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program