ID   TUSC_BUCAP              Reviewed;         119 AA.
AC   Q8K945;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 94.
DE   RecName: Full=Protein TusC {ECO:0000255|HAMAP-Rule:MF_00389};
DE   AltName: Full=tRNA 2-thiouridine synthesizing protein C {ECO:0000255|HAMAP-Rule:MF_00389};
GN   Name=tusC {ECO:0000255|HAMAP-Rule:MF_00389};
GN   OrderedLocusNames=BUsg_512;
OS   Buchnera aphidicola subsp. Schizaphis graminum (strain Sg).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=198804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sg;
RX   PubMed=12089438; DOI=10.1126/science.1071278;
RA   Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA   Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT   "50 million years of genomic stasis in endosymbiotic bacteria.";
RL   Science 296:2376-2379(2002).
CC   -!- FUNCTION: Part of a sulfur-relay system required for 2-thiolation of 5-
CC       methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
CC       {ECO:0000255|HAMAP-Rule:MF_00389}.
CC   -!- SUBUNIT: Heterohexamer, formed by a dimer of trimers. The hexameric
CC       TusBCD complex contains 2 copies each of TusB, TusC and TusD. The
CC       TusBCD complex interacts with TusE. {ECO:0000255|HAMAP-Rule:MF_00389}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00389}.
CC   -!- SIMILARITY: Belongs to the DsrF/TusC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00389}.
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DR   EMBL; AE013218; AAM68055.1; -; Genomic_DNA.
DR   RefSeq; WP_044006062.1; NC_004061.1.
DR   AlphaFoldDB; Q8K945; -.
DR   SMR; Q8K945; -.
DR   STRING; 198804.BUsg_512; -.
DR   GeneID; 75258602; -.
DR   KEGG; bas:BUsg_512; -.
DR   eggNOG; COG2923; Bacteria.
DR   HOGENOM; CLU_155943_1_0_6; -.
DR   Proteomes; UP000000416; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.1260.10; DsrEFH-like; 1.
DR   HAMAP; MF_00389; Thiourid_synth_C; 1.
DR   InterPro; IPR027396; DsrEFH-like.
DR   InterPro; IPR003787; Sulphur_relay_DsrE/F-like.
DR   InterPro; IPR037450; Sulphur_relay_TusC.
DR   InterPro; IPR017462; Sulphur_relay_TusC/DsrF.
DR   NCBIfam; TIGR03010; sulf_tusC_dsrF; 1.
DR   PANTHER; PTHR38780; PROTEIN TUSC; 1.
DR   PANTHER; PTHR38780:SF1; PROTEIN TUSC; 1.
DR   Pfam; PF02635; DsrE; 1.
DR   SUPFAM; SSF75169; DsrEFH-like; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; tRNA processing.
FT   CHAIN           1..119
FT                   /note="Protein TusC"
FT                   /id="PRO_0000214881"
SQ   SEQUENCE   119 AA;  13610 MW;  6EE924AD44058CC0 CRC64;
     MEKIAFVFSH APHGTSFGKE GLDVILGVSS IIKKISLFFI GDGVLQILKH SKSENILARN
     YTSSFRILSI YDIKNFYCCK SSLIDRGLYS HNQFILKVNI LNSYFFRIKL DDHDAIINF
//