Q8K945 (TUSC_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein TusC

Alternative name(s):
tRNA 2-thiouridine synthesizing protein C

Gene names

Name:	tusC
Ordered Locus Names:	BUsg_512

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Schizaphis graminum)

Protein attributes

Sequence length	119 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm5s2U) at tRNA wobble positions By similarity. HAMAP-Rule MF_00389
Subunit structure	Heterohexamer, formed by a dimer of trimers. The hexameric TusBCD complex contains 2 copies each of TusB, TusC and TusD. The TusBCD complex interacts with TusE By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the DsrF/TusC family.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Cytoplasm
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tRNA processing Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 119	119	Protein TusC HAMAP-Rule MF_00389		PRO_0000214881

Sequences

	Sequence		Length	Mass (Da)
	Q8K945 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 6EE924AD44058CC0	FASTA	119	13,610
	10 20 30 40 50 60 MEKIAFVFSH APHGTSFGKE GLDVILGVSS IIKKISLFFI GDGVLQILKH SKSENILARN 70 80 90 100 110 YTSSFRILSI YDIKNFYCCK SSLIDRGLYS HNQFILKVNI LNSYFFRIKL DDHDAIINF

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013218 Genomic DNA. Translation: AAM68055.1.
RefSeq	NP_660844.2. NC_004061.1.
3D structure databases
ProteinModelPortal	Q8K945.
ModBase	Search...
Protein-protein interaction databases
STRING	198804.BUsg512.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM68055; AAM68055; BUsg_512.
GeneID	1005659.
KEGG	bas:BUsg512.
PATRIC	21247888. VBIBucAph100086_0539.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2923.
KO	K07236.
OMA	LILEVEW.
ProtClustDB	PRK00211.
Enzyme and pathway databases
BioCyc	BAPH198804:GHMG-557-MONOMER.
Family and domain databases
HAMAP	MF_00389. Thiourid_synth_C.
InterPro	IPR003787. Sulphur_relay_DrsE/F-like. IPR017462. Sulphur_relay_TusC/DsrF. [Graphical view]
Pfam	PF02635. DrsE. 1 hit. [Graphical view]
TIGRFAMs	TIGR03010. sulf_tusC_dsrF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TUSC_BUCAP

Accession

Primary (citable) accession number: Q8K945

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program