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Q8K939 (AROB_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:BUsg_519
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

NAD By similarity. HAMAP MF_00110

Divalent metal cations By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm Probable HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3603603-dehydroquinate synthase HAMAP MF_00110
PRO_0000140718

Sequences

Sequence LengthMass (Da)Tools
Q8K939 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 0E64F383F667CCC6

FASTA36039,993
        10         20         30         40         50         60 
MEQLKVVLGK RSYPINIGSS IIQEDNIFWP LNPGNQAMLI TNKTLANLFK DKVFFHLRKS 

        70         80         90        100        110        120 
GIKIDQVILS DGEQFKTLNE MEVIISALLE KKHSRDTTLI ALGGGVIGDL TGFSASIYQR 

       130        140        150        160        170        180 
GVRFIQIPTT LLSQVDASVG GKTGVNHLLG KNMVGSFWQP SSVIIDINFL KTLPYNELVS 

       190        200        210        220        230        240 
GMAEVIKYAV IFDANFFEWL EENIENLLLL NDELMSYCIK KCCELKAQII ALDERENNFR 

       250        260        270        280        290        300 
ALLNFGHTYG HAIEAHAGYG SWLHGEAISV GMVMASRTSE LIGCLKKTDY KRILSLLKKA 

       310        320        330        340        350        360 
GLPVKGPKNM SAASYLPYMM RDKKVISGEM RLVLPISIGK AKIYSGIDKN IILSAIKDSQ

« Hide

References

[1]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE013218 Genomic DNA. Translation: AAM68062.1.
RefSeqNP_660851.1. NC_004061.1.

3D structure databases

ProteinModelPortalQ8K939.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000000036; EBBUCP00000000036; EBBUCG00000000036.
GeneID1005654.
GenomeReviewsGene locus BUsg_519 in contig AE013218_GR.
KEGGbas:BUsg519.
PATRIC21247902. VBIBucAph100086_0546.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000008095.
HOGENOMHBG632303.
OMAVMALEMS.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycBAPH198804:BUSG519-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_BUCAP
AccessionPrimary (citable) accession number: Q8K939
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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