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Protein

Peptide chain release factor 3

Gene

prfC

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 27GTPUniRule annotation8
Nucleotide bindingi88 – 92GTPUniRule annotation5
Nucleotide bindingi142 – 145GTPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH198804:G1FZU-554-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide chain release factor 3UniRule annotation
Short name:
RF-3UniRule annotation
Gene namesi
Name:prfCUniRule annotation
Ordered Locus Names:BUsg_523
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000416 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002109341 – 529Peptide chain release factor 3Add BLAST529

Proteomic databases

PRIDEiQ8K935

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg523

Structurei

3D structure databases

ProteinModelPortaliQ8K935
SMRiQ8K935
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 280tr-type GAdd BLAST270

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8A Bacteria
COG4108 LUCA
KOiK02837
OMAiVFKIHAN
OrthoDBiPOG091H00HD

Family and domain databases

Gene3Di3.30.70.3280, 1 hit
HAMAPiMF_00072 Rel_fac_3, 1 hit
InterProiView protein in InterPro
IPR035647 EFG_III/V
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR004548 PrfC
IPR032090 RF3_C
IPR038467 RF3_C_sf
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
PANTHERiPTHR43556 PTHR43556, 1 hit
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF16658 RF3_C, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF52540 SSF52540, 1 hit
SSF54980 SSF54980, 1 hit
TIGRFAMsiTIGR00503 prfC, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K935-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNINHQLEL SKRRTFAIIS HPDAGKTTVT EKMLLLGKVI RTSGTIKARG
60 70 80 90 100
NGKYAKSDWM NIEKKRGISI TTSVMQFTYK NTLMNLLDTP GHEDFSEDTY
110 120 130 140 150
RILTAVDCCL LIIDAAKGIE DRTKKLINVS RLHNTPVITF INKLDRDSRE
160 170 180 190 200
AIEILDEIEK ELSLDCIPIT WPISCGKNFK GICHIHDKIV NLYQKNIVKK
210 220 230 240 250
INFNSFSSFL NEHSLKEYLG ADLYTQLHEE LKLAAYVYPK FSKKKFLKGD
260 270 280 290 300
ITPVLFGSAL NNFGIDHILE SLIKWAPSPI YRVTKTRKVE PEEKKFTGFV
310 320 330 340 350
FKIQANMDLK HRDRIAFMRI VSGKYKKGIK LRHVRMKKDI IVSDAFSFLA
360 370 380 390 400
GDRFSIEHAY PGDVIGIHNH GTIKIGDTFT EGEEIKFVGI PSFAPEVFRR
410 420 430 440 450
IFLKNPLQQK KLKKGLSQLS EEGAIQVFRP MINNSLILGA IGILQFDVVI
460 470 480 490 500
ERLKIEYKID AIYERVNISL ARWIRSKNKK IISDFINKNK SYLALDISNQ
510 520
LIYLAPNKAN LAVIKNIYNN IFFEKTREQ
Length:529
Mass (Da):60,738
Last modified:October 1, 2002 - v1
Checksum:iB13984DD4305833B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA Translation: AAM68066.1
RefSeqiWP_011054032.1, NC_004061.1

Genome annotation databases

EnsemblBacteriaiAAM68066; AAM68066; BUsg_523
KEGGibas:BUsg_523

Similar proteinsi

Entry informationi

Entry nameiRF3_BUCAP
AccessioniPrimary (citable) accession number: Q8K935
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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