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Q8K935

- RF3_BUCAP

UniProt

Q8K935 - RF3_BUCAP

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Protein
Peptide chain release factor 3
Gene
prfC, BUsg_523
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 278GTP By similarity
Nucleotide bindingi88 – 925GTP By similarity
Nucleotide bindingi142 – 1454GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. GTPase activity Source: InterPro
  3. translation release factor activity, codon specific Source: UniProtKB-HAMAP

GO - Biological processi

  1. regulation of translational termination Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-552-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide chain release factor 3
Short name:
RF-3
Gene namesi
Name:prfC
Ordered Locus Names:BUsg_523
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Peptide chain release factor 3UniRule annotation
PRO_0000210934Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg523.

Structurei

3D structure databases

ProteinModelPortaliQ8K935.
SMRiQ8K935. Positions 9-529.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 280270tr-type G
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4108.
KOiK02837.
OMAiFHKTREH.
OrthoDBiEOG6677Q1.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00072. Rel_fac_3.
InterProiIPR000795. EF_GTP-bd_dom.
IPR009022. EFG_III-V.
IPR027417. P-loop_NTPase.
IPR004548. PrfC.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54980. SSF54980. 1 hit.
TIGRFAMsiTIGR00503. prfC. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K935-1 [UniParc]FASTAAdd to Basket

« Hide

MFNINHQLEL SKRRTFAIIS HPDAGKTTVT EKMLLLGKVI RTSGTIKARG    50
NGKYAKSDWM NIEKKRGISI TTSVMQFTYK NTLMNLLDTP GHEDFSEDTY 100
RILTAVDCCL LIIDAAKGIE DRTKKLINVS RLHNTPVITF INKLDRDSRE 150
AIEILDEIEK ELSLDCIPIT WPISCGKNFK GICHIHDKIV NLYQKNIVKK 200
INFNSFSSFL NEHSLKEYLG ADLYTQLHEE LKLAAYVYPK FSKKKFLKGD 250
ITPVLFGSAL NNFGIDHILE SLIKWAPSPI YRVTKTRKVE PEEKKFTGFV 300
FKIQANMDLK HRDRIAFMRI VSGKYKKGIK LRHVRMKKDI IVSDAFSFLA 350
GDRFSIEHAY PGDVIGIHNH GTIKIGDTFT EGEEIKFVGI PSFAPEVFRR 400
IFLKNPLQQK KLKKGLSQLS EEGAIQVFRP MINNSLILGA IGILQFDVVI 450
ERLKIEYKID AIYERVNISL ARWIRSKNKK IISDFINKNK SYLALDISNQ 500
LIYLAPNKAN LAVIKNIYNN IFFEKTREQ 529
Length:529
Mass (Da):60,738
Last modified:October 1, 2002 - v1
Checksum:iB13984DD4305833B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM68066.1.
RefSeqiNP_660855.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM68066; AAM68066; BUsg_523.
GeneIDi1005652.
KEGGibas:BUsg523.
PATRICi21247912. VBIBucAph100086_0550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM68066.1 .
RefSeqi NP_660855.1. NC_004061.1.

3D structure databases

ProteinModelPortali Q8K935.
SMRi Q8K935. Positions 9-529.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg523.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM68066 ; AAM68066 ; BUsg_523 .
GeneIDi 1005652.
KEGGi bas:BUsg523.
PATRICi 21247912. VBIBucAph100086_0550.

Phylogenomic databases

eggNOGi COG4108.
KOi K02837.
OMAi FHKTREH.
OrthoDBi EOG6677Q1.

Enzyme and pathway databases

BioCyci BAPH198804:GHMG-552-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00072. Rel_fac_3.
InterProi IPR000795. EF_GTP-bd_dom.
IPR009022. EFG_III-V.
IPR027417. P-loop_NTPase.
IPR004548. PrfC.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54980. SSF54980. 1 hit.
TIGRFAMsi TIGR00503. prfC. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiRF3_BUCAP
AccessioniPrimary (citable) accession number: Q8K935
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi