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Q8K926

- MUTY_BUCAP

UniProt

Q8K926 - MUTY_BUCAP

Protein

A/G-specific adenine glycosylase

Gene

mutY

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Adenine glycosylase active on G-A and C-A mispairs.By similarity

    Cofactori

    Binds 1 4Fe-4S cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi192 – 1921Iron-sulfur (4Fe-4S)By similarity
    Metal bindingi199 – 1991Iron-sulfur (4Fe-4S)By similarity
    Metal bindingi202 – 2021Iron-sulfur (4Fe-4S)By similarity
    Metal bindingi208 – 2081Iron-sulfur (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. DNA binding Source: InterPro
    3. DNA N-glycosylase activity Source: InterPro
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. base-excision repair Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    DNA damage, DNA repair

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-563-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    A/G-specific adenine glycosylase (EC:3.2.2.-)
    Gene namesi
    Name:mutY
    Ordered Locus Names:BUsg_534
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347A/G-specific adenine glycosylasePRO_0000102232Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi198804.BUsg534.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K926.
    SMRiQ8K926. Positions 1-223.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Nth/MutY family.Curated

    Phylogenomic databases

    eggNOGiCOG1194.
    KOiK03575.
    OMAiEADWLWY.
    OrthoDBiEOG6RNQH0.

    Family and domain databases

    Gene3Di1.10.1670.10. 1 hit.
    1.10.340.30. 1 hit.
    3.90.79.10. 1 hit.
    InterProiIPR005760. A/G_AdeGlyc_MutY.
    IPR011257. DNA_glycosylase.
    IPR004036. Endonuclease-III-like_CS2.
    IPR004035. Endouclease-III_FeS-bd_BS.
    IPR003651. Endouclease3_FeS-loop_motif.
    IPR003265. HhH-GPD_domain.
    IPR000445. HhH_motif.
    IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR023170. HTH_base_excis_C.
    IPR029119. MutY_C.
    IPR015797. NUDIX_hydrolase_dom-like.
    [Graphical view]
    PfamiPF00633. HHH. 1 hit.
    PF00730. HhH-GPD. 1 hit.
    PF14815. NUDIX_4. 1 hit.
    [Graphical view]
    SMARTiSM00478. ENDO3c. 1 hit.
    SM00525. FES. 1 hit.
    SM00278. HhH1. 1 hit.
    [Graphical view]
    SUPFAMiSSF48150. SSF48150. 1 hit.
    SSF55811. SSF55811. 1 hit.
    TIGRFAMsiTIGR01084. mutY. 1 hit.
    PROSITEiPS00764. ENDONUCLEASE_III_1. 1 hit.
    PS01155. ENDONUCLEASE_III_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K926-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTIYVFSQLI LNWYHINGRK NLPWKKDKTL YKVWISEIML QQTTVKTAIP    50
    YFKNFISRFP NIQSLNQSKL DDILCLWSGL GYYKRAENIY KTVKIIKEEF 100
    QEKFPTGFSD LIKLPGIGRS TAGAILSLSL DYFFPILEGN VKRILMRYYG 150
    IIGYVTEKKI EQKLWYLIEL ITPIHNTGSF NQGIMDIGAL ICTPKNPKCN 200
    LCPLIQKCIA YKEKNWIKYP LKKKKKIILE KKSWFVVIKY QNQFWIEKNT 250
    EKKIWKNLFC FPNFDTKIKT IEWLKKNKIN IDKKHKKIQS FYHKFSHFTL 300
    HIIPILVNLS FFKNFQNSKK TGIWYDLKNT HDIGLPKPVQ KILEIFK 347
    Length:347
    Mass (Da):41,301
    Last modified:October 1, 2002 - v1
    Checksum:iD6F6279175293587
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM68075.1.
    RefSeqiNP_660864.1. NC_004061.1.
    WP_011054041.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM68075; AAM68075; BUsg_534.
    GeneIDi1005544.
    KEGGibas:BUsg534.
    PATRICi21247940. VBIBucAph100086_0564.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM68075.1 .
    RefSeqi NP_660864.1. NC_004061.1.
    WP_011054041.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali Q8K926.
    SMRi Q8K926. Positions 1-223.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg534.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM68075 ; AAM68075 ; BUsg_534 .
    GeneIDi 1005544.
    KEGGi bas:BUsg534.
    PATRICi 21247940. VBIBucAph100086_0564.

    Phylogenomic databases

    eggNOGi COG1194.
    KOi K03575.
    OMAi EADWLWY.
    OrthoDBi EOG6RNQH0.

    Enzyme and pathway databases

    BioCyci BAPH198804:GHMG-563-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1670.10. 1 hit.
    1.10.340.30. 1 hit.
    3.90.79.10. 1 hit.
    InterProi IPR005760. A/G_AdeGlyc_MutY.
    IPR011257. DNA_glycosylase.
    IPR004036. Endonuclease-III-like_CS2.
    IPR004035. Endouclease-III_FeS-bd_BS.
    IPR003651. Endouclease3_FeS-loop_motif.
    IPR003265. HhH-GPD_domain.
    IPR000445. HhH_motif.
    IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR023170. HTH_base_excis_C.
    IPR029119. MutY_C.
    IPR015797. NUDIX_hydrolase_dom-like.
    [Graphical view ]
    Pfami PF00633. HHH. 1 hit.
    PF00730. HhH-GPD. 1 hit.
    PF14815. NUDIX_4. 1 hit.
    [Graphical view ]
    SMARTi SM00478. ENDO3c. 1 hit.
    SM00525. FES. 1 hit.
    SM00278. HhH1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48150. SSF48150. 1 hit.
    SSF55811. SSF55811. 1 hit.
    TIGRFAMsi TIGR01084. mutY. 1 hit.
    PROSITEi PS00764. ENDONUCLEASE_III_1. 1 hit.
    PS01155. ENDONUCLEASE_III_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiMUTY_BUCAP
    AccessioniPrimary (citable) accession number: Q8K926
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3