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Protein

A/G-specific adenine glycosylase

Gene

mutY

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Adenine glycosylase active on G-A and C-A mispairs.By similarity

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi192 – 1921Iron-sulfur (4Fe-4S)By similarity
Metal bindingi199 – 1991Iron-sulfur (4Fe-4S)By similarity
Metal bindingi202 – 2021Iron-sulfur (4Fe-4S)By similarity
Metal bindingi208 – 2081Iron-sulfur (4Fe-4S)By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA N-glycosylase activity Source: InterPro
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. base-excision repair Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-563-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
A/G-specific adenine glycosylase (EC:3.2.2.-)
Gene namesi
Name:mutY
Ordered Locus Names:BUsg_534
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347A/G-specific adenine glycosylasePRO_0000102232Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg534.

Structurei

3D structure databases

ProteinModelPortaliQ8K926.
SMRiQ8K926. Positions 1-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Nth/MutY family.Curated

Phylogenomic databases

eggNOGiCOG1194.
KOiK03575.
OMAiMERGVDY.
OrthoDBiEOG6RNQH0.

Family and domain databases

Gene3Di1.10.1670.10. 1 hit.
1.10.340.30. 1 hit.
3.90.79.10. 1 hit.
InterProiIPR005760. A/G_AdeGlyc_MutY.
IPR011257. DNA_glycosylase.
IPR004036. Endonuclease-III-like_CS2.
IPR004035. Endouclease-III_FeS-bd_BS.
IPR003651. Endouclease3_FeS-loop_motif.
IPR003265. HhH-GPD_domain.
IPR000445. HhH_motif.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR023170. HTH_base_excis_C.
IPR029119. MutY_C.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00633. HHH. 1 hit.
PF00730. HhH-GPD. 1 hit.
PF14815. NUDIX_4. 1 hit.
[Graphical view]
SMARTiSM00478. ENDO3c. 1 hit.
SM00525. FES. 1 hit.
SM00278. HhH1. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.
SSF55811. SSF55811. 1 hit.
TIGRFAMsiTIGR01084. mutY. 1 hit.
PROSITEiPS00764. ENDONUCLEASE_III_1. 1 hit.
PS01155. ENDONUCLEASE_III_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K926-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTIYVFSQLI LNWYHINGRK NLPWKKDKTL YKVWISEIML QQTTVKTAIP
60 70 80 90 100
YFKNFISRFP NIQSLNQSKL DDILCLWSGL GYYKRAENIY KTVKIIKEEF
110 120 130 140 150
QEKFPTGFSD LIKLPGIGRS TAGAILSLSL DYFFPILEGN VKRILMRYYG
160 170 180 190 200
IIGYVTEKKI EQKLWYLIEL ITPIHNTGSF NQGIMDIGAL ICTPKNPKCN
210 220 230 240 250
LCPLIQKCIA YKEKNWIKYP LKKKKKIILE KKSWFVVIKY QNQFWIEKNT
260 270 280 290 300
EKKIWKNLFC FPNFDTKIKT IEWLKKNKIN IDKKHKKIQS FYHKFSHFTL
310 320 330 340
HIIPILVNLS FFKNFQNSKK TGIWYDLKNT HDIGLPKPVQ KILEIFK
Length:347
Mass (Da):41,301
Last modified:October 1, 2002 - v1
Checksum:iD6F6279175293587
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM68075.1.
RefSeqiNP_660864.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM68075; AAM68075; BUsg_534.
GeneIDi1005544.
KEGGibas:BUsg534.
PATRICi21247940. VBIBucAph100086_0564.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM68075.1.
RefSeqiNP_660864.1. NC_004061.1.

3D structure databases

ProteinModelPortaliQ8K926.
SMRiQ8K926. Positions 1-223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198804.BUsg534.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM68075; AAM68075; BUsg_534.
GeneIDi1005544.
KEGGibas:BUsg534.
PATRICi21247940. VBIBucAph100086_0564.

Phylogenomic databases

eggNOGiCOG1194.
KOiK03575.
OMAiMERGVDY.
OrthoDBiEOG6RNQH0.

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-563-MONOMER.

Family and domain databases

Gene3Di1.10.1670.10. 1 hit.
1.10.340.30. 1 hit.
3.90.79.10. 1 hit.
InterProiIPR005760. A/G_AdeGlyc_MutY.
IPR011257. DNA_glycosylase.
IPR004036. Endonuclease-III-like_CS2.
IPR004035. Endouclease-III_FeS-bd_BS.
IPR003651. Endouclease3_FeS-loop_motif.
IPR003265. HhH-GPD_domain.
IPR000445. HhH_motif.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR023170. HTH_base_excis_C.
IPR029119. MutY_C.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00633. HHH. 1 hit.
PF00730. HhH-GPD. 1 hit.
PF14815. NUDIX_4. 1 hit.
[Graphical view]
SMARTiSM00478. ENDO3c. 1 hit.
SM00525. FES. 1 hit.
SM00278. HhH1. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.
SSF55811. SSF55811. 1 hit.
TIGRFAMsiTIGR01084. mutY. 1 hit.
PROSITEiPS00764. ENDONUCLEASE_III_1. 1 hit.
PS01155. ENDONUCLEASE_III_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiMUTY_BUCAP
AccessioniPrimary (citable) accession number: Q8K926
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: February 4, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.