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Q8K926 (MUTY_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
A/G-specific adenine glycosylase

EC=3.2.2.-
Gene names
Name:mutY
Ordered Locus Names:BUsg_534
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Adenine glycosylase active on G-A and C-A mispairs By similarity.

Cofactor

Binds 1 4Fe-4S cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand By similarity.

Sequence similarities

Belongs to the Nth/MutY family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 347347A/G-specific adenine glycosylase
PRO_0000102232

Sites

Metal binding1921Iron-sulfur (4Fe-4S) By similarity
Metal binding1991Iron-sulfur (4Fe-4S) By similarity
Metal binding2021Iron-sulfur (4Fe-4S) By similarity
Metal binding2081Iron-sulfur (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8K926 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: D6F6279175293587

FASTA34741,301
        10         20         30         40         50         60 
MTIYVFSQLI LNWYHINGRK NLPWKKDKTL YKVWISEIML QQTTVKTAIP YFKNFISRFP 

        70         80         90        100        110        120 
NIQSLNQSKL DDILCLWSGL GYYKRAENIY KTVKIIKEEF QEKFPTGFSD LIKLPGIGRS 

       130        140        150        160        170        180 
TAGAILSLSL DYFFPILEGN VKRILMRYYG IIGYVTEKKI EQKLWYLIEL ITPIHNTGSF 

       190        200        210        220        230        240 
NQGIMDIGAL ICTPKNPKCN LCPLIQKCIA YKEKNWIKYP LKKKKKIILE KKSWFVVIKY 

       250        260        270        280        290        300 
QNQFWIEKNT EKKIWKNLFC FPNFDTKIKT IEWLKKNKIN IDKKHKKIQS FYHKFSHFTL 

       310        320        330        340 
HIIPILVNLS FFKNFQNSKK TGIWYDLKNT HDIGLPKPVQ KILEIFK 

« Hide

References

[1]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE013218 Genomic DNA. Translation: AAM68075.1.
RefSeqNP_660864.1. NC_004061.1.

3D structure databases

ProteinModelPortalQ8K926.
SMRQ8K926. Positions 1-223.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198804.BUsg534.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM68075; AAM68075; BUsg_534.
GeneID1005544.
KEGGbas:BUsg534.
PATRIC21247940. VBIBucAph100086_0564.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1194.
KOK03575.
OMAEADWLWY.
OrthoDBEOG6RNQH0.

Enzyme and pathway databases

BioCycBAPH198804:GHMG-563-MONOMER.

Family and domain databases

Gene3D1.10.1670.10. 1 hit.
1.10.340.30. 1 hit.
3.90.79.10. 1 hit.
InterProIPR005760. A/G_AdeGlyc_MutY.
IPR011257. DNA_glycosylase.
IPR004036. Endonuclease-III-like_CS2.
IPR004035. Endouclease-III_FeS-bd_BS.
IPR003651. Endouclease3_FeS-loop_motif.
IPR003265. HhH-GPD_domain.
IPR000445. HhH_motif.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR023170. HTH_base_excis_C.
IPR029119. MutY_C.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamPF00633. HHH. 1 hit.
PF00730. HhH-GPD. 1 hit.
PF14815. NUDIX_4. 1 hit.
[Graphical view]
SMARTSM00478. ENDO3c. 1 hit.
SM00525. FES. 1 hit.
SM00278. HhH1. 1 hit.
[Graphical view]
SUPFAMSSF48150. SSF48150. 1 hit.
SSF55811. SSF55811. 1 hit.
TIGRFAMsTIGR01084. mutY. 1 hit.
PROSITEPS00764. ENDONUCLEASE_III_1. 1 hit.
PS01155. ENDONUCLEASE_III_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMUTY_BUCAP
AccessionPrimary (citable) accession number: Q8K926
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: June 11, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names