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Protein

Adenine DNA glycosylase

Gene

mutY

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Adenine glycosylase active on G-A and C-A mispairs.By similarity

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei37Proton donor/acceptorBy similarity1
Sitei138Transition state stabilizerBy similarity1
Metal bindingi192Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi199Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi202Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi208Iron-sulfur (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processDNA damage, DNA repair
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine DNA glycosylase (EC:3.2.2.-)
Gene namesi
Name:mutY
Ordered Locus Names:BUsg_534
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000416 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001022321 – 347Adenine DNA glycosylaseAdd BLAST347

Interactioni

Protein-protein interaction databases

STRINGi198804.BUsg534.

Structurei

3D structure databases

ProteinModelPortaliQ8K926.
SMRiQ8K926.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Nth/MutY family.Curated

Phylogenomic databases

eggNOGiENOG4105CEN. Bacteria.
COG1194. LUCA.
KOiK03575.
OMAiRDPYRVW.
OrthoDBiPOG091H01HV.

Family and domain databases

CDDicd03431. DNA_Glycosylase_C. 1 hit.
cd00056. ENDO3c. 1 hit.
Gene3Di1.10.1670.10. 1 hit.
InterProiView protein in InterPro
IPR005760. A/G_AdeGlyc_MutY.
IPR011257. DNA_glycosylase.
IPR004036. Endonuclease-III-like_CS2.
IPR003651. Endonuclease3_FeS-loop_motif.
IPR004035. Endouclease-III_FeS-bd_BS.
IPR003265. HhH-GPD_domain.
IPR000445. HhH_motif.
IPR023170. HTH_base_excis_C.
IPR029119. MutY_C.
IPR015797. NUDIX_hydrolase_dom-like.
PfamiView protein in Pfam
PF00633. HHH. 1 hit.
PF00730. HhH-GPD. 1 hit.
PF14815. NUDIX_4. 1 hit.
SMARTiView protein in SMART
SM00478. ENDO3c. 1 hit.
SM00525. FES. 1 hit.
SUPFAMiSSF48150. SSF48150. 1 hit.
SSF55811. SSF55811. 1 hit.
TIGRFAMsiTIGR01084. mutY. 1 hit.
PROSITEiView protein in PROSITE
PS00764. ENDONUCLEASE_III_1. 1 hit.
PS01155. ENDONUCLEASE_III_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K926-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIYVFSQLI LNWYHINGRK NLPWKKDKTL YKVWISEIML QQTTVKTAIP
60 70 80 90 100
YFKNFISRFP NIQSLNQSKL DDILCLWSGL GYYKRAENIY KTVKIIKEEF
110 120 130 140 150
QEKFPTGFSD LIKLPGIGRS TAGAILSLSL DYFFPILEGN VKRILMRYYG
160 170 180 190 200
IIGYVTEKKI EQKLWYLIEL ITPIHNTGSF NQGIMDIGAL ICTPKNPKCN
210 220 230 240 250
LCPLIQKCIA YKEKNWIKYP LKKKKKIILE KKSWFVVIKY QNQFWIEKNT
260 270 280 290 300
EKKIWKNLFC FPNFDTKIKT IEWLKKNKIN IDKKHKKIQS FYHKFSHFTL
310 320 330 340
HIIPILVNLS FFKNFQNSKK TGIWYDLKNT HDIGLPKPVQ KILEIFK
Length:347
Mass (Da):41,301
Last modified:October 1, 2002 - v1
Checksum:iD6F6279175293587
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013218 Genomic DNA. Translation: AAM68075.1.
RefSeqiWP_011054041.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM68075; AAM68075; BUsg_534.
KEGGibas:BUsg_534.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMUTY_BUCAP
AccessioniPrimary (citable) accession number: Q8K926
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2002
Last modified: June 7, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families