Q8K915 (HFLC_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein HflC
EC=3.4.-.-

Gene names

Name:	hflC
Ordered Locus Names:	BUsg_547

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Schizaphis graminum)

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	HflC and HflK could encode or regulate a protease By similarity.
Subunit structure	HflC and HflK may interact to form a multimeric complex By similarity.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the band 7/mec-2 family. HflC subfamily.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase Protease Serine protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW regulation of peptidase activity Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	serine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	Protein HflC		PRO_0000094071
Regions
	Transmembrane	3 – 23	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8K915 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 0ED2B7509FF43F34	FASTA	307	35,444
	10 20 30 40 50 60 MNKIVICILS FFLLIFSSSF FIVKEGERGI ILQFGKVLRN NKQKTLVYTP GLHFKIPFFE 70 80 90 100 110 120 NVKILDSRIH TMDNQADRFV TKEKKDLIVD SYIKWRISDF SRYYLATGGG DFFQAEVLLK 130 140 150 160 170 180 RKFSDRLRSE IGRLNVKEIV TDSRGRLTTD VLYSLNKGTI NLDSTSLINV NSMNALGIEV 190 200 210 220 230 240 VDVRIKQINL PLEVSDAIYN RMRAERESVA RSQRSQGQEK AEKLRATADY RVSLILAEAQ 250 260 270 280 290 300 KKALMIKGQG EAEVAKLFLE NFGQESSFYF FIRSLHAYEN SFKNSNNIML INSDNEFFKY MNTEIKN

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013218 Genomic DNA. Translation: AAM68086.1.
RefSeq	NP_660875.1. NC_004061.1.
3D structure databases
ProteinModelPortal	Q8K915.
ModBase	Search...
Protein-protein interaction databases
STRING	198804.BUsg547.
Protein family/group databases
MEROPS	I87.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM68086; AAM68086; BUsg_547.
GeneID	1005822.
KEGG	bas:BUsg547.
PATRIC	21247972. VBIBucAph100086_0578.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0330.
KO	K04087.
OMA	PQFAQFY.
ProtClustDB	PRK11029.
Enzyme and pathway databases
BioCyc	BAPH198804:GHMG-578-MONOMER.
Family and domain databases
InterPro	IPR001107. Band_7. IPR010200. HflC. IPR001972. Stomatin. [Graphical view]
PANTHER	PTHR10264. PTHR10264. 1 hit.
Pfam	PF01145. Band_7. 1 hit. [Graphical view]
PIRSF	PIRSF005651. HflC. 1 hit.
SMART	SM00244. PHB. 1 hit. [Graphical view]
TIGRFAMs	TIGR01932. hflC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HFLC_BUCAP

Accession

Primary (citable) accession number: Q8K915

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2002
Last modified:	May 29, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program