Reviewed, UniProtKB/Swiss-Prot Q8K912 (MTLD_BUCAP)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	BUsg_551

Organism

Buchnera aphidicola subsp. Schizaphis graminum [Complete proteome] [HAMAP]

Taxonomic identifier

98794 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_0000170700
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8K912-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 58A1E3D0EA624A82	FASTA	388	44,572
	10 20 30 40 50 60 MRALHFGAGN IGRGFIARVL LKSDFNLIFS DVDQNIINAI NNYKKYKIKL IDNSFEKIIN 70 80 90 100 110 120 INNISAINSY DPNVLNVISH VDLITTAAGV NALYKIASIL IEGIILRINL KCKKPLNIIA 130 140 150 160 170 180 CENKIKATSF LKKIIFDKIP LKYHDYFDEY IGFVDCTIDT IVPTFSSFKE ENSLFVIAEN 190 200 210 220 230 240 FKEWIVDVNQ FKGMVPKIID MTLSDNLTSF IDRKILTLNT GHAIAAYLGL MKNYKNICEA 250 260 270 280 290 300 MSDFSIQRIV KDAMYESGLV LIKRYNFNKK DHLSYIDKIF VRFKNPFILD KLERIARNPL 310 320 330 340 350 360 QKLSKDERLI QPFVEAMKYN LPYFNLVKGI AAALHYRNIN DIQSIKLSSL IKEEGLEETL 370 380 VKVCKLNANS NEIRIIISEY HSIIKDFL

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE013218 Genomic DNA. Translation: AAM68089.1.
RefSeq	NP_660878.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1005536.
GenomeReviews	Gene locus BUsg_551 in contig AE013218_GR.
KEGG	bas:BUsg551.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8K912.
OMA	Q8K912. VDRIVPN.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG551-MON.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_BUCAP

Accession

Primary (citable) accession number: Q8K912

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)