ID   CITX_STRP3              Reviewed;         192 AA.
AC   Q8K7F0;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-JUN-2009, entry version 40.
DE   RecName: Full=Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferase;
DE            EC=2.7.7.61;
DE   AltName: Full=Holo-ACP synthase;
DE   AltName: Full=Holo-citrate lyase synthase;
DE   AltName: Full=Apo-ACP nucleodityltransferase;
GN   Name=citX; OrderedLocusNames=SpyM3_0835, SPs1035;
OS   Streptococcus pyogenes serotype M3.
OC   Bacteria; Firmicutes; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301448;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-595 / MGAS315 / Serotype M3;
RX   MEDLINE=22133808; PubMed=12122206; DOI=10.1073/pnas.152298499;
RA   Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S.,
RA   Mammarella N.D., Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D.,
RA   Campbell D.S., Smith T.M., McCormick J.K., Leung D.Y.M.,
RA   Schlievert P.M., Musser J.M.;
RT   "Genome sequence of a serotype M3 strain of group A Streptococcus:
RT   phage-encoded toxins, the high-virulence phenotype, and clone
RT   emergence.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SSI-1 / Serotype M3;
RX   MEDLINE=22683278; PubMed=12799345; DOI=10.1101/gr.1096703;
RA   Nakagawa I., Kurokawa K., Yamashita A., Nakata M., Tomiyasu Y.,
RA   Okahashi N., Kawabata S., Yamazaki K., Shiba T., Yasunaga T.,
RA   Hayashi H., Hattori M., Hamada S.;
RT   "Genome sequence of an M3 strain of Streptococcus pyogenes reveals a
RT   large-scale genomic rearrangement in invasive strains and new insights
RT   into phage evolution.";
RL   Genome Res. 13:1042-1055(2003).
CC   -!- FUNCTION: Transfers 2-(5''-triphosphoribosyl)-3'-
CC       dephosphocoenzyme-A on a serine residue to the apo-acyl carrier
CC       protein (gamma chain) of the citrate lyase to yield holo-acyl
CC       carrier protein (By similarity).
CC   -!- CATALYTIC ACTIVITY: 2'-(5-triphosphoribosyl)-3'-dephospho-CoA +
CC       citrate lyase apo-[acyl-carrier-protein] = citrate lyase holo-
CC       [acyl-carrier-protein] + diphosphate.
CC   -!- SIMILARITY: Belongs to the citX family.
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DR   EMBL; AE014074; AAM79442.1; -; Genomic_DNA.
DR   EMBL; BA000034; BAC64130.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_664639.1; -.
DR   RefSeq; NP_802297.1; -.
DR   GeneID; 1009149; -.
DR   GeneID; 1065052; -.
DR   GenomeReviews; AE014074_GR; SpyM3_0835.
DR   GenomeReviews; BA000034_GR; SPs1035.
DR   KEGG; spg:SpyM3_0835; -.
DR   KEGG; sps:SPs1035; -.
DR   HOGENOM; Q8K7F0; -.
DR   OMA; Q8K7F0; TGYEYYL.
DR   BioCyc; SPYO193567:SPS1035-MON; -.
DR   BioCyc; SPYO198466:SPYM3_0835-MON; -.
DR   GO; GO:0050519; F:holo-citrate lyase synthase activity; IEA:HAMAP.
DR   HAMAP; MF_00398; -; 1.
DR   InterPro; IPR005551; CitX.
DR   Pfam; PF03802; CitX; 1.
DR   TIGRFAMs; TIGR03124; ctirate_citX; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Nucleotidyltransferase; Transferase.
FT   CHAIN         1    192       Probable apo-citrate lyase
FT                                phosphoribosyl-dephospho-CoA transferase.
FT                                /FTId=PRO_0000214689.
SQ   SEQUENCE   192 AA;  21646 MW;  5F314CC12808D0F4 CRC64;
     MCKDTYFSGE AIQLSDMLRA REERALRQLH LLKEYPEGSL LSVTMNIPGP IKTSPKLLEV
     FDIVIKAIQT ALADDKICYQ LRLLPTTGYE YYLITSLPSR DLKLKMIALE TELPIGRLMD
     LDVLVLQNDL PHSISRTVLG GSPRQCFICS KEAKVCGRLR KHSVEEMQTA ISKLLHSFFN
     KDNQSSSSDK TG
//